DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and sctr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_031749751.1	Gene:	sctr / 101735213	XenbaseID:	XB-GENE-959831	Length:	447	Species:	Xenopus tropicalis

Alignment Length:	434	Identity:	119/434 - (27%)
Similarity:	199/434 - (45%)	Gaps:	63/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAI-RKCELDGRWGSR-PNATEVNPPGWTD 278
            |...||.:.|||.:..|..||:.||....|:..::.:: |.|..|| |.:: |:..|.     ..
Frog    57 CGGMWDNISCWPSSAHGETARIPCPEILRGLTGQQGSLYRNCTEDG-WSAKFPSIDEA-----CG 115

  Fly   279 YGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTK 343
            |.......::..|                ..:||...|...||.:|.::|.:..:||.||..|..
Frog   116 YDANVTENVVYFM----------------HLKTLYSTGYGTSLASLALALALLASFRRLRCTRNY 164

  Fly   344 IHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLL--EYARTAMFM 406
            ||.:||.:.:|:.   :::::       |:|...::..|.....|..:.||:::  :|...|.:.
Frog   165 IHMHLFASFILRA---MSIFI-------KDAVLYSTEEVNHCNVYSTDCSYMMIFFQYCIMANYS 219

  Fly   407 WMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNL-T 470
            |:.:||||||.::.::.|.......::..|||..|::....||.|..:|.|..   | |:.|. .
Frog   220 WLLVEGLYLHTLLVISFFSEWKYFCWYIALGWGSPLVFIIAWAVCRHLYDDFG---C-WDINSNA 280

  Fly   471 PYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQA---SDIEQTRKAVRAAIVLLPLLGITNL 532
            ..:||:.||.:..|.:||...|.|||:|:.||:.|..   :|:.|.::..|:.::|:||.|:..:
Frog   281 SVWWIIRGPIILSIFINFILFVRIIRILMKKLKTSDVVSRNDLGQYKRLARSTLLLIPLFGVHYM 345

  Fly   533 LHQLAP-------LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRG 590
            :....|       :|....|.:      .|.|||||.:|::||||||||::.:.:..     :|.
Frog   346 VFAFFPEDVSSGTVKIRLTFEL------TLGSFQGFVVAVLYCFLNGEVQSEIHRKW-----LRW 399

  Fly   591 H-PEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNK 633
            | .|:...|....|...|.|.....|.|....|...:|.:|..|
Frog   400 HFREYFLLRQQKNSTVSNGATMLTQVLPVSRGSNKEQRKAPAQK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	19/57 (33%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	76/269 (28%)
sctr	XP_031749751.1	HRM	56..117	CDD:397086	19/65 (29%)
		7tmB1_secretin	127..398	CDD:320403	86/311 (28%)
		TM helix 1	130..154	CDD:320403	7/23 (30%)
		TM helix 2	163..184	CDD:320403	5/30 (17%)
		TM helix 3	204..226	CDD:320403	6/21 (29%)
		TM helix 4	245..261	CDD:320403	4/15 (27%)
		TM helix 5	279..302	CDD:320403	7/22 (32%)
		TM helix 6	330..352	CDD:320403	5/21 (24%)
		TM helix 7	360..385	CDD:320403	12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110