DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and glp1r

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_031758064.1	Gene:	glp1r / 101734463	XenbaseID:	XB-GENE-940017	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	106/403 - (26%)
Similarity:	178/403 - (44%)	Gaps:	63/403 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 ENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGF---HGVDTRKFAIRKCELD 259
            :.|.:.|.......||.:||.|:|...|||....|....:.||...   |.| |.....|.|..:
Frog    33 QQCLSSFQQVPTLLTGRFCNRTFDDYACWPDALPGTYVNVTCPWYLPWSHKV-THGRVFRYCTPE 96

  Fly   260 GRWGSRPNATEVNPPGWTDYGPC------YKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLC 318
            |.|..:.|::    ..|.:...|      ..||     :|:.|            ...:..:|..
Frog    97 GNWLLKENSS----APWRNLSECEDRSLKVPPE-----EQLSS------------LSVIYTIGYS 140

  Fly   319 LSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYL-DQFRRGNKEAATNTS--- 379
            ||..|||::.:|...||.|...|..||.|||.:.:|:.|   :::: |...:.....|.|.:
Frog   141 LSFSALIIATIILVRFRHLHCTRNYIHLNLFTSFILRAI---SVFIKDSVLKWMYNLAMNDNQWE 202

  Fly   380 --LSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPI 442
              :|..|:..  |...:.:::|...|.:.|:.:||:|||.::.::||......:.:..:||.||:
Frog   203 GLVSYQESLS--CRLVFAMMQYCVAANYYWLLVEGIYLHTLLVLSVFSEQRLFRLYLCIGWGVPV 265

  Fly   443 LMTTVWARCTVMYMDTSLGECLW--NYNLTPYYW-ILEGPRLAVILLNFCFLVNIIRVLVMKLRQ 504
            |....||....:|.|..   | |  |||:.  :| |:..|.|..|.:||...:.:|.:::.||:.
Frog   266 LFVVPWAIVKYLYEDNG---C-WTRNYNMN--FWLIIRLPILMAIGVNFVIFIRVICIIISKLQA 324

  Fly   505 SQASDIEQTRKAVRAAIVLLPLLGITNLL-------HQLAPLKTATNFAVWSYGTHFLTSFQGFF 562
            :.....:...:..::.:.|:||||...::       |....|:....|...|:     :||||..
Frog   325 NLMCRTDTKCRLAKSTLTLIPLLGTHEIIFAFITDEHAKGALRYIKLFFELSF-----SSFQGLM 384

  Fly   563 IALIYCFLNGEVR 575
            :|::|||:|.||:
Frog   385 VAILYCFINNEVQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	19/61 (31%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	71/272 (26%)
glp1r	XP_031758064.1	HRM	48..116	CDD:397086	20/72 (28%)
		7tmB1_GLP1R	128..406	CDD:341342	79/298 (27%)
		TM helix 1	131..155	CDD:341342	7/23 (30%)
		TM helix 2	164..185	CDD:341342	7/23 (30%)
		TM helix 3	214..236	CDD:341342	4/21 (19%)
		TM helix 4	255..271	CDD:341342	5/15 (33%)
		TM helix 5	289..312	CDD:341342	8/24 (33%)
		TM helix 6	337..359	CDD:341342	5/21 (24%)
		TM helix 7	368..393	CDD:341342	10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010