DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and glp2r

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_004919620.2	Gene:	glp2r / 101731683	XenbaseID:	XB-GENE-6044800	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	132/463 - (28%)
Similarity:	212/463 - (45%)	Gaps:	75/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 TGLYCNWTWDTLLCWPPTPAGVLARMNCP-------GGFHGVDTRKFAIRKCELDGRWGSRPNAT 269
            ||:|||.|:|...|||.:..|.:: :.||       .|..|:     ..|.|..:|.|.:..|:|
Frog    60 TGVYCNGTFDHFACWPHSRPGNVS-VPCPWYLPWAQPGSTGL-----VYRVCSEEGVWQTAENST 118

  Fly   270 EVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTF 334
            .:    |.|:|.|......:    ...||:.:...:    :.:..:|..:||.||:::|:|...|
Frog   119 SI----WRDHGECSGKNHFK----QNDKDYASLSAL----QIIYTIGYSISLGALLLALVILLLF 171

  Fly   335 RSLRNNRTKIHKNLFVAMV---LQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVL 396
            |.|...|..||.|||.:.:   |.|:|:..:|.:.:.:.|.|....:.|:...:|.  |..:.|.
Frog   172 RKLHCTRNYIHMNLFASFIMRALAVLIKDIVYKNTYFKKNDEMGWMSHLTSEISTS--CRVAQVF 234

  Fly   397 LEYARTAMFMWMFIEGLYLHN-MVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSL 460
            :.:...|.:.|:|:||||||. :|||.:.:....||:.. :||..|:|....|....:.|.:..
Frog   235 MHFFVGANYCWLFVEGLYLHTILVTVILSEKGLLLKYLF-IGWFFPLLFVVPWVIAKLYYENNG- 297

  Fly   461 GECLWNYNLTP-YYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLL 524
              | |..|.:| .:||:.||.|..||:||...:.::::|..||:..|....:...:..||.:.|:
Frog   298 --C-WGVNESPGIWWIIRGPMLLGILINFLIFIKVLKLLYSKLKAQQMRYTDCKYRLARATLALI 359

  Fly   525 PLLGITNLLHQLAPLKTATNFAVWSYGTHF-------LTSFQGFFIALIYCFLNGEVRAVLLKSL 582
            ||||:.:::...     .|:..|.....||       ..|||||.:|:.|||.||||||.|.|
Frog   360 PLLGMHHVVFTF-----ITDELVEGATRHFWLLIQLAFESFQGFVVAIFYCFTNGEVRAELRK-- 417

  Fly   583 ATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNK--RLNG-----RKP 640
                      :|     :::...|...............|.:.|  ||.||  |.||     ::|
Frog   418 ----------QW-----NLFLLRYFPCQSYFIDNTVKYQSKSSK--SPRNKVIRKNGFYQEDKRP 465

  Fly   641 SSASIVMI 648
            ||..::.:
Frog   466 SSVRLLNV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	20/65 (31%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	79/268 (29%)
glp2r	XP_004919620.2	HRM	61..117	CDD:397086	18/61 (30%)
		7tmB1_GLP2R	143..421	CDD:320394	92/310 (30%)
		TM helix 1	146..170	CDD:320394	7/27 (26%)
		TM helix 2	179..200	CDD:320394	8/20 (40%)
		TM helix 3	229..251	CDD:320394	5/21 (24%)
		TM helix 4	270..286	CDD:320394	5/16 (31%)
		TM helix 5	304..327	CDD:320394	10/22 (45%)
		TM helix 6	352..374	CDD:320394	7/26 (27%)
		TM helix 7	383..408	CDD:320394	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010