Protein Alignment Pdfr and calcr

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_002934645.2
• Gene: calcr / 100491101
• XenbaseID: XB-GENE-952135
• Length: 478
• Species: Xenopus tropicalis
• Alignment Length: 413
• Identity: 131/413 - (31%)
• Similarity: 201/413 - (48%)
• Gaps: 54/413 - (13%)

  Fly   211 QTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPG 275
            ::|||||.|||..|||..||||:....|||..|...|..:.|.:.|:.:|.|...|.:...
 Frog    75 KSGLYCNRTWDGWLCWDDTPAGINVTQNCPDYFPDFDPTERASKYCDENGNWFQHPESNRT---- 135

  Fly   276 WTDYGPC--YKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLR 338
            |::|..|  :..|.:::          |||     ...:.|||..||:.:|::||.||..|:||.
 Frog   136 WSNYTLCNSFTSEKLKM----------AYI-----LYYMAIVGHALSIVSLMISLGIFFYFKSLS 185

  Fly   339 NNRTKIHKNLFVAMVLQ---VIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYA 400
            ..|..:|||||.:.||.   .|:.||             |......::.:.|..|:......:|.
 Frog   186 CQRITLHKNLFTSYVLNSVFTIVHLT-------------AVVPDTDLVRSDPVSCKVLQFFSQYM 237

  Fly   401 RTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLW 465
            ....:.||..||:|||.::.||||.....|.::..|||..|::..::.|.....|.:.:   | |
 Frog   238 LGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLGWGFPLVPASIHAFARTKYFNDN---C-W 298

  Fly   466 NYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGIT 530
            ....|...:|:.||.:|.:|:|..||:||:.|||.|||.:..::.....|||||.::|:|||||.
 Frog   299 MSVETHLLYIVHGPIMAALLVNLFFLLNIVLVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQ 363

  Fly   531 NLLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPE 593
            .::.   |.:..|..|  ::.|..:.|..:||..:|.|:||.||||:..|.:..     ::...:
 Frog   364 FVIF---PWRPDTRLAGEIYDYIMNILMHYQGLLVATIFCFFNGEVQGALKRQW-----MQYKTQ 420

  Fly   594 WAPKR---ASMYSGAYNTAPDTD 613
            |..:|   .||.|.:|.....|:
 Frog   421 WGQRRREHCSMRSTSYTATSITE 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	25/58 (43%)
		7tmB1_PDFR	306..584	CDD:320389	92/282 (33%)
		TM helix 1	308..333	CDD:320389	10/24 (42%)
		TM helix 2	342..364	CDD:320389	10/24 (42%)
		TM helix 3	391..418	CDD:320389	8/26 (31%)
		TM helix 4	430..450	CDD:320389	5/19 (26%)
		TM helix 5	469..498	CDD:320389	11/28 (39%)
		TM helix 6	512..539	CDD:320389	11/26 (42%)
		TM helix 7	546..571	CDD:320389	9/26 (35%)
calcr	XP_002934645.2	HRM	77..145	CDD:397086	28/71 (39%)
		7tmB1_calcitonin_R	153..426	CDD:341343	96/302 (32%)
		TM helix 1	155..180	CDD:341343	11/29 (38%)
		TM helix 2	189..211	CDD:341343	8/21 (38%)
		TM helix 3	228..255	CDD:341343	8/26 (31%)
		TM helix 4	267..287	CDD:341343	5/19 (26%)
		TM helix 5	302..331	CDD:341343	11/28 (39%)
		TM helix 6	345..372	CDD:341343	12/29 (41%)
		TM helix 7	378..403	CDD:341343	8/24 (33%)