DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and pth2r

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_031749364.1	Gene:	pth2r / 100488565	XenbaseID:	XB-GENE-1018413	Length:	545	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	128/463 - (27%)
Similarity:	201/463 - (43%)	Gaps:	92/463 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LALEPTVMDALPDSD-----TEQV--LGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGL 214
            |.:...|::...|||     .||:  |.........|:|:......:  ||        :|:
Frog    14 LTISKCVVEGQVDSDDTVTMEEQIYLLWEAKEQCELNITVQLQEEDS--NC--------IPE--- 65

  Fly   215 YCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWG--SRPNATEVNPPGWT 277
                 ||.|:|||....|.:..::||...:..:.|..|.|:|.::|.|.  .|.|.|..|
Frog    66 -----WDGLVCWPRGIPGRILAVSCPSYVYDFNHRGLAYRRCNINGTWDFVHRLNKTFAN----- 120

  Fly   278 DYGPC---YKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRN 339
             |..|   .|||     :..|.::|      ..|...:..||..:|..:|.|::.|...||.|..
Frog   121 -YTECLHFLKPE-----RSQGKREF------FERLYVMYTVGYSISFCSLAVAIFIIGYFRRLHC 173

  Fly   340 NRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGN---KEAATNTSLS----------------VIEN 385
            .|..||.:|||:.:|             |.|:   |:...:|.:.                |::.
Frog   174 TRNYIHMHLFVSFML-------------RAGSIFIKDKVVHTHIGVKELDAVLMGDLMISPVLDK 225

  Fly   386 TPYL-CEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWA 449
            :.|: |:.:.|:..|.....:.|:.:||||||:::.||.|..:..|..|:.:||..|.:...:||
Frog   226 SQYVGCKIAVVMFIYFLATNYYWILVEGLYLHSLIFVAFFSDTKYLWGFTLIGWGFPAVFVVIWA 290

  Fly   450 RCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIE--- 511
            .......|   ..| |..:.....||.:.|.||.|.|||...:|.:|||..|:.:|.|...:
Frog   291 VARATLAD---ARC-WELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWESNAVGYDTRK 351

  Fly   512 QTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTH---FLTSFQGFFIALIYCFLNGE 573
            |.||..::.:||:.:.|:..::....| .|.|..| |....|   |..||||||:::|||:.|||
Frog   352 QYRKLAKSTLVLILVFGVHYIVFVCLP-HTFTGLA-WEIRMHCELFFNSFQGFFVSIIYCYCNGE 414

  Fly   574 VRAVLLKS 581
            |:..:.|:
Frog   415 VQTEIKKT 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/60 (30%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	80/282 (28%)
pth2r	XP_031749364.1	HRM	62..124	CDD:397086	22/83 (27%)
		7tmB1_PTH2R	140..425	CDD:320648	89/302 (29%)
		TM helix 1	143..167	CDD:320648	6/23 (26%)
		TM helix 2	176..197	CDD:320648	8/33 (24%)
		TM helix 3	232..254	CDD:320648	4/21 (19%)
		TM helix 4	273..289	CDD:320648	4/15 (27%)
		TM helix 5	306..329	CDD:320648	9/22 (41%)
		TM helix 6	357..379	CDD:320648	4/22 (18%)
		TM helix 7	387..412	CDD:320648	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010