Protein Alignment Pdfr and gcgr

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_004916426.1
• Gene: gcgr / 100487356
• XenbaseID: XB-GENE-5918476
• Length: 483
• Species: Xenopus tropicalis
• Alignment Length: 431
• Identity: 118/431 - (27%)
• Similarity: 180/431 - (41%)
• Gaps: 78/431 - (18%)

  Fly   210 PQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGF-------HGVDTRKFAIRKCELDGRWGSRPN 267
            |..||.||.|:|...|||.........:.||...       ||:     ..:.||.||:|..|
 Frog    48 PAAGLVCNRTFDRYCCWPDALPNTTVSVPCPWFLPWHLKVQHGL-----VYKHCEPDGQWAER-- 105

  Fly   268 ATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFC 332
                      |...|...:     :|:..|.|..|.:.    :.:..||..:||..||::..|..
 Frog   106 ----------DAQECENDD-----KQIEDKYFKIYDNF----KIMYTVGYSVSLGTLILAFAILV 151

  Fly   333 TFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLD---QFRRGNKEAATNTSLSVIENTPYLCEASY 394
            .|..|...|..||.|||.:.:|:.:  ..|.||   :.|....|...:|.|.:.......|..:.
 Frog   152 GFSKLHCMRNYIHINLFASFILRAV--SVLVLDTMLKTRYNENEKFEDTHLWLSSEALVGCRVAA 214

  Fly   395 VLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTS 459
            ||::|...|.:.|:.:||:||:|::.:|||........:..:||..|.|....|......|.:|.
 Frog   215 VLMQYGIIANYYWLMVEGIYLYNLLVLAVFSERSYFALYLCIGWGAPALFIIPWVAVRYTYENTL 279

  Fly   460 LGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLL 524
               |....|...::||:....|..|::||...|.||::||.|:|..|....:...:..::.:.|:
 Frog   280 ---CWSTNNNMGFWWIIRSSVLLAIVINFVIFVRIIQILVSKMRAHQMRYTDYKFRLAKSTLTLI 341

  Fly   525 PLLGITNLLHQLAPLKTATNFAVWSYGT---------HFLTSFQGFFIALIYCFLNGEVRAVLLK 580
            |||||..:.....|.:|.       :||         .|::||||..:|::|||:|.||::.|||
 Frog   342 PLLGIHEVAFAFLPEETV-------HGTLRLVKLFFDLFISSFQGMLVAVLYCFVNKEVQSELLK 399

  Fly   581 SLATQLSVRGHPEWAPKRASM-------YSGAYNTAPDTDA 614
                        :|  ||..:       |...|...|...|
 Frog   400 ------------KW--KRWKLGKDIKGEYKHTYTQTPRVGA 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	19/65 (29%)
		7tmB1_PDFR	306..584	CDD:320389	85/289 (29%)
		TM helix 1	308..333	CDD:320389	7/24 (29%)
		TM helix 2	342..364	CDD:320389	7/21 (33%)
		TM helix 3	391..418	CDD:320389	9/26 (35%)
		TM helix 4	430..450	CDD:320389	5/19 (26%)
		TM helix 5	469..498	CDD:320389	9/28 (32%)
		TM helix 6	512..539	CDD:320389	6/26 (23%)
		TM helix 7	546..571	CDD:320389	11/33 (33%)
gcgr	XP_004916426.1	HRM	51..113	CDD:397086	21/78 (27%)
		7tmB1_GCGR	123..403	CDD:320395	87/309 (28%)
		TM helix 1	127..152	CDD:320395	7/28 (25%)
		TM helix 2	161..183	CDD:320395	8/23 (35%)
		TM helix 3	211..238	CDD:320395	9/26 (35%)
		TM helix 4	250..270	CDD:320395	5/19 (26%)
		TM helix 5	286..315	CDD:320395	9/28 (32%)
		TM helix 6	331..356	CDD:320395	6/24 (25%)
		TM helix 7	365..390	CDD:320395	9/24 (38%)