DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and LOC100487239

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_002932473.2	Gene:	LOC100487239 / 100487239	-ID:	-	Length:	431	Species:	Xenopus tropicalis

Alignment Length:	443	Identity:	118/443 - (26%)
Similarity:	192/443 - (43%)	Gaps:	80/443 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LTLASAAATN-FENCSALFVNY----------TLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCP 240
            ||::..||:. .|.....::.|          |...:||:||.|:|...|||....|.:..:.||
Frog    20 LTISQKAASQVLERTVEEWMRYRDECYKRMASTPHPSGLHCNRTFDMYACWPDGTPGTITYVPCP 84

  Fly   241 GGF-------HGVDTRKFAIRKCELDGRW--GSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGS 296
            ...       ||:     ..::|..||.|  |:|..|       |.:...|...      .::.:
Frog    85 YYLPWFQKVSHGL-----LSQRCGKDGLWVKGNRSQA-------WRNVSQCEDD------TEVTA 131

  Fly   297 KDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQ---VII 358
            ::.:.. |:....|.|..||..:||..||.:|||....|.||..|..||.|||.:..|:   ||:
Frog   132 EEVETR-DLLLSFRALYTVGYSVSLLTLISALLILTMCRKLRCTRNSIHANLFASFALRAVSVIV 195

  Fly   359 RLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAV 423
            :..|...::.....| .::..:.:.:.....|..:.|:::|...|...|..:|.:||:.::..||
Frog   196 KDVLLAKRWGMQITE-VSDWEVLISDQAAIGCRIAQVVMQYCILANHYWFVVEAVYLYKLLIGAV 259

  Fly   424 FQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLW--NYNLTPYYWILEGPRLAVILL 486
            |........:..|||..|:|....|.  |:.|:..: .|| |  |.|:. |:||:..|.|...|:
Frog   260 FSEKNYYTLYLYLGWGTPVLFVVPWV--TLKYLKEN-SEC-WALNENMA-YWWIIRIPILLASLI 319

  Fly   487 NFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAP----------LKT 541
            |....:.|::|::.|||.:|....:...:..:|.:.|:||.||..::...|.          :|.
Frog   320 NLVIFMRILKVILSKLRANQKGYADYKLRLAKATLTLIPLFGIHEVVFIFATDEQTSGILRYIKV 384

  Fly   542 ATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEW 594
            ..|.        ||.|||||.:|::|||.|.||::.:            |.:|
Frog   385 FFNL--------FLNSFQGFLVAVLYCFANKEVKSEI------------HKKW 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	21/67 (31%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	78/271 (29%)
LOC100487239	XP_002932473.2	HRM	57..126	CDD:367186	23/80 (29%)
		7tmB1_GlucagonR-like_1	140..419	CDD:320651	87/304 (29%)
		TM helix 1	142..167	CDD:320651	11/24 (46%)
		TM helix 2	176..198	CDD:320651	8/21 (38%)
		TM helix 3	227..254	CDD:320651	7/26 (27%)
		TM helix 4	266..286	CDD:320651	6/21 (29%)
		TM helix 5	302..331	CDD:320651	9/29 (31%)
		TM helix 6	345..372	CDD:320651	7/26 (27%)
		TM helix 7	381..406	CDD:320651	13/32 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020