DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment z and RB1

DIOPT Version :9

Sequence 1:	NP_001259190.1	Gene:	z / 31230	FlyBaseID:	FBgn0004050	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_000312.2	Gene:	RB1 / 5925	HGNCID:	9884	Length:	928	Species:	Homo sapiens

Alignment Length:	177	Identity:	36/177 - (20%)
Similarity:	64/177 - (36%)	Gaps:	60/177 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 PTVTAATTVPAAVPVP-VATASSGSANSVAVNTSTASSVSINNTSLGGGGGNGATNASATAADSF 504
            ||....:..|..:|:. ..||:....:.|.......|:..:|:|:          ||...|..:|
Human   582 PTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTA----------NAETQATSAF 636

  Fly   505 EER---------MNYFKI-REAELRCKE--QQLATEAKRIE-------LNKAQDELKYMKEVH-- 548
            :.:         :.|.|: |.|.||...  ::|.:|...:|       .:..|:|.:.|::.|
Human   637 QTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLD 701

  Fly   549 -----------RLRVEELTMKI-----------------RILQKEEE 567
                       :::..:|..||                 |:|.||||
Human   702 QIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
z	NP_001259190.1	GT1	53..125	CDD:304916
RB1	NP_000312.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		DUF3452	114..225	CDD:371807
		Pocket, binds T and E1A	373..771		36/177 (20%)
		Domain A	373..579
		RB_A	373..573	CDD:366846
		Spacer	580..639		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..632		6/31 (19%)
		Domain B	640..771		22/109 (20%)
		RB_B	646..765	CDD:366845	22/103 (21%)
		Interaction with LIMD1. /evidence=ECO:0000269\|PubMed:15542589	763..928
		Rb_C	768..924	CDD:370194
		Domain C, mediates interaction with E4F1. /evidence=ECO:0000269\|PubMed:10869426	771..928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..928
		Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P13405	860..876
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3143
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950