DRSC/TRiP Functional Genomics Resources

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Protein Alignment z and Rb1

DIOPT Version :9

Sequence 1:NP_001259190.1 Gene:z / 31230 FlyBaseID:FBgn0004050 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_033055.2 Gene:Rb1 / 19645 MGIID:97874 Length:921 Species:Mus musculus


Alignment Length:206 Identity:37/206 - (17%)
Similarity:71/206 - (34%) Gaps:50/206 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 DIKHRKKQRNKYSV--RETWDKIVKDFNS-----------------HPHVSAMRNIKQIQKFWLN 121
            |:.|..::..|..:  .|.:|.|:..:||                 .|.:|.:.:|.:....:.:
Mouse   723 DLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSS 787

  Fly   122 SRLR----------KQYPYRDGSSSNLSSGSAKISSVSVSVASAVPQQQQQQHHQQHDSVKVEPE 176
            |.||          .:.||:........:.....|.:.||:..:....::   .|:.:.:....:
Mouse   788 SPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEK---FQKINQMVCNSD 849

  Fly   177 YQISPDASEHNPQADTFDEIEMDANDVSEIDED---PMEQQQQQQQEAQAQAQAQAQAQAQVQSA 238
            ..:...|...|| .....::..|.....|.|..   |.|.:.||:             .|::.|.
Mouse   850 RVLKRSAEGGNP-PKPLKKLRFDIEGADEADGSKHLPAESKFQQK-------------LAEMTST 900

  Fly   239 AAEMQKMQQVN 249
            ...||| |::|
Mouse   901 RTRMQK-QRMN 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zNP_001259190.1 GT1 53..125 CDD:304916 12/67 (18%)
Rb1NP_033055.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
DUF3452 112..219 CDD:371807
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..360
Pocket, binds T and E1A. /evidence=ECO:0000250 367..764 8/40 (20%)
Domain A. /evidence=ECO:0000250 367..573
RB_A 367..567 CDD:366846
Spacer. /evidence=ECO:0000250 574..632
Domain B. /evidence=ECO:0000250 633..764 8/40 (20%)
RB_B 639..758 CDD:366845 8/34 (24%)
Interaction with LIMD1. /evidence=ECO:0000250 756..921 29/173 (17%)
Rb_C 761..917 CDD:370194 29/168 (17%)
Domain, mediates interaction with E4F1. /evidence=ECO:0000250 764..921 29/165 (18%)
Bipartite nuclear localization signal. /evidence=ECO:0000269|PubMed:8336704 853..869 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..921 13/53 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3143
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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