DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and ROBO2

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_011532283.1	Gene:	ROBO2 / 6092	HGNCID:	10250	Length:	1597	Species:	Homo sapiens

Alignment Length:	1386	Identity:	286/1386 - (20%)
Similarity:	421/1386 - (30%)	Gaps:	492/1386 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CI---YTLQASDSNSSVATTLGVL---FERAPESAVAPKGDEVVFECE---------LNLKPDRL 66
            |:   |..:|...|:|:...|  |   |.:.|...|...|:..:.||:         :..|.|::
Human   133 CVARNYLGEAVSRNASLEVAL--LRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV 195

  Fly    67 EWRFRRGDSSEPYLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGALASTPARL 131
                 |.|..|..:.:|  .|..:.|.:           ....||.|.||.....|...|.||.|
Human   196 -----RIDDKEERISIR--GGKLMISNT-----------RKSDAGMYTCVGTNMVGERDSDPAEL 242

  Fly   132 ALVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRNGKKLPQSELLPGAAG 196
            .       |.:.....|..|...|..:..:..|| .|..:|.....:.::...||:.........
Human   243 T-------VFERPTFLRRPINQVVLEEEAVEFRC-QVQGDPQPTVRWKKDDADLPRGRYDIKDDY 299

  Fly   197 ALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTPPYFLQRPPIEYSARPGETVV 261
            .|.:....:.|.|.|.|:|.|.:...|.....|:..|    ...||.|:.||..:..|: |.||.
Human   300 TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAR----PVAPPQFVVRPRDQIVAQ-GRTVT 359

  Fly   262 LECPGVGSPRPRVIWSS--------PNVVEIYNNRSTILSYG-LQITDVKPEDQGSYICMLDNGI 317
            ..|...|:|:|.|.|..        ||..:..|:|.::...| |.||:::..|.|.|||..
Human   360 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQA---- 420

  Fly   318 APPIDHTIKLSVLQR--------------PTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLI 368
                 .|:..|:|.:              |.||:|||..........||.|.|:|:|.|.|.||.
Human   421 -----LTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLK 480

  Fly   369 NG-EDATKDPEAVVDNR-SLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPL 431
            .| ....:||.|.:..: :||:|.::....|...|.|.:..||||...:|.|.....|...:..|
Human   481 EGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDL 545

  Fly   432 GEVPVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGL 496
            .::|                                 .|||:|.||.::..||.|.|. |...|
Human   546 SDLP---------------------------------GPPSKPQVTDVTKNSVTLSWQ-PGTPG- 575

  Fly   497 QITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFT 561
              |.....|.:....::...:|||.::::                                |...
Human   576 --TLPASAYIIEAFSQSVSNSWQTVANHV--------------------------------KTTL 606

  Fly   562 SSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNLPV------------------ 608
            .:|.||.....|.|.:.|:     |.:|       |.:.:..|: ||
Human   607 YTVRGLRPNTIYLFMVRAI-----NPQG-------LSDPSPMSD-PVRTQDISPPAQGVDHRQVQ 658

  Fly   609 PELREVETLSESAVVLHWSLVSST-----QNEDIDGYYAYYR-----PADSAAEYLKATVDGGMS 663
            .||.:|.....:.|||..:.|..|     |.:.|.||...||     .|.|:.:.|.|.|.  ..
Human   659 KELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP--TE 721

  Fly   664 RSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKTHEQPA--------------SSSATP 714
            ||..:..|:.|..||.|::.:.::.....|..:..||  |.|.|:              :|::..
Human   722 RSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRT--TEEAPSAPPQSVTVLTVGSYNSTSIS 784

  Fly   715 VPANKAVEQHQN---------------------------------SLYPLI--------AGAAGG 738
            |..:.....|||                                 .|:|.|        :.:||.
Human   785 VSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGV 849

  Fly   739 GILLLIASLVVCLCLKRRENSQPEDENKPQLEHIQADFV--TSAVLGVGG--------------- 786
            |:......:::     .|.|.....||...:.....|.|  .:.:.|:||
Human   850 GVKSEPQPIII-----GRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYW 909

  Fly   787 -------------HHKSGDVRRL-NGVIPRM-------------------------NITPNPLAQ 812
                         ..:.||...: ||..|.:                         |..||.:..
Human   910 RRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGN 974

  Fly   813 ETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERS---------NAEEQ------------- 855
            ....|         .|||:.........|..|.|:..|         |:..|
Human   975 FGRGD---------VLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQIL 1030

  Fly   856 QDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLPQKHD--------QEQLDAPNAVLEAP---- 908
            .....||....||             |...|.::.||.|        .:|....||:|..|
Human  1031 HSNSIHELAVDLP-------------DPQWKSSIQQKTDLMGFGYSLPDQNKGNNALLYIPDYRL 1082

  Fly   909 ---------------------------------------------SK------------PLPPLP 916
                                                         ||            ||||.|
Human  1083 AEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPP 1147

  Fly   917 KKPANGAGQNNSGLHQ--NGLHHAQPYHPP-GTPTLMHKRL-------DYHQQPPPV------PP 965
            .:|..|....:..:.|  || :.:..:.|| ...|.:|:.|       |.....|||      |.
Human  1148 VQPLPGTELEHYAVEQQENG-YDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPA 1211

  Fly   966 HSAYYQQAPTHQPSPMMERSVRGHQQPG-GFHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHSNL 1029
            .|...|...|..|||      |...||. ..|::|.|         |..:.....|..|
Human  1212 ISFGQQSTATLTPSP------REEMQPMLQAHLDELT---------RAYQFDIAKQTWH------ 1255

  Fly  1030 NIGLSHHNNNNNNLPPHHQHLHHHPGHPGGLVGIPIV------------PGSPRVQRSPMPSRAM 1082
                    ..:||.||      ..|..|.|.|...::            .........|.|.||:
Human  1256 --------IQSNNQPP------QPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRAL 1306

  Fly  1083 IKRTRLGSHTDNISSGSLNSI 1103
            .:..  ||..||:.|....|:
Human  1307 DQTP--GSSMDNLDSSVTGSM 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	22/97 (23%)
		IG_like	154..234	CDD:214653	16/79 (20%)
		Ig	172..234	CDD:299845	12/61 (20%)
		IG_like	249..329	CDD:214653	24/88 (27%)
		Ig	257..329	CDD:299845	23/80 (29%)
		IG_like	339..418	CDD:214653	27/80 (34%)
		Ig	352..408	CDD:299845	19/57 (33%)
		FN3	470..592	CDD:238020	26/121 (21%)
		FN3	613..700	CDD:238020	25/96 (26%)
ROBO2	XP_011532283.1	Ig1_Robo	53..152	CDD:143317	5/18 (28%)
		Ig	160..244	CDD:325142	23/108 (21%)
		Ig	265..333	CDD:325142	14/68 (21%)
		Ig4_Robo	355..444	CDD:143203	25/97 (26%)
		IG	451..532	CDD:214652	27/80 (34%)
		FN3	549..642	CDD:238020	31/174 (18%)
		FN3	673..758	CDD:238020	23/86 (27%)
		FN3	766..859	CDD:238020	11/92 (12%)
		PTN13_u3	<1374..>1431	CDD:318742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010