DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and IGDCC4

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_016877937.1	Gene:	IGDCC4 / 57722	HGNCID:	13770	Length:	1264	Species:	Homo sapiens

Alignment Length:	1340	Identity:	274/1340 - (20%)
Similarity:	424/1340 - (31%)	Gaps:	443/1340 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNL----KPDRLEWRFRRGDS--SEP 78
            |::.|.....:...||      ||.|       .|..|.|..    .|.|:.|. :.||:  ...
Human    46 TVELSCGVGPLQVILG------PEQA-------AVLNCSLGAAAAGPPTRVTWS-KDGDTLLEHD 96

  Fly    79 YLYLRPSAGYNVT-----SGSDGLAWRLRIYVSAQTA-----GDYQCVAWYGP-GALASTPARLA 132
            :|:|.|:....::     :|||         .|...|     |:|.|:| :|| |.|||..|.:.
Human    97 HLHLLPNGSLWLSQPLAPNGSD---------ESVPEAVGVIEGNYSCLA-HGPLGVLASQTAVVK 151

  Fly   133 LVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSV-----ISNPPA-IWSFYRNGKKLPQSE-- 189
            |.::|              .:|:.|::..:...|:.     |...|| |.::.::...||:..
Human   152 LATLA--------------DFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRL 202

  Fly   190 -LLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDY-----TDRTPPYFLQRP 248
             :||.  |.|.:..|...|||.|.||||||.   .....|...|.|.:     :.|.....:...
Human   203 IVLPN--GVLQILDVQESDAGPYRCVATNSA---RQHFSQEALLSVAHRGSLASTRGQDVVIVAA 262

  Fly   249 PIEYSARPGETVVLECPGVGSPRPRVIWSSPNVVEIYNNRSTILSYGLQITDVKPEDQGSYICML 313
            |...:...|::||:||.....|.|.|.|...:...|..:...:....|.|.:.:|...|.|:|..
Human   263 PENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRA 327

  Fly   314 ------DNGIAPPIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGED 372
                  |...|     ..:|.||..|.|.:.|.|.....::.....|.|||.|:|.:.||.||..
Human   328 NKPRTRDFATA-----AAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 387

  Fly   373 ATKDPEAVVD--NRSLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVP 435
            ...:....|.  ..||.:.::..:.||..||.|:|
Human   388 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN------------------------------ 422

  Fly   436 VWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVP--PSRPNVTRLSDESVMLRWSVPQNSGLQI 498
                   :.||..::.|.....:.|        :|  |:|...|.||..:|::.|..|:....||
Human   423 -------SAGMACAAASLAVVVREG--------LPSAPTRVTATPLSSSAVLVAWERPEMHSEQI 472

  Fly   499 ----------------------------------------TFFKVQYRMLGDGKNRRKNWQTTSD 523
                                                    .|:.|.|..||..:........|.|
Human   473 IGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLD 537

  Fly   524 NIPYG--NAHGSGPGQGN------------SHWRARNRDREYEMGNPPKNFTSSVTG-------- 566
            ::|..  ....|.|...:            |:.:......||.:|...:.|::.|.|
Human   538 DVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLN 602

  Fly   567 -LTAGKYYRFRIVAVYSNNDNKEGNTSLKF-----FLQNGT----SKSNLP-VPELREVETLSES 620
             |...|.||.||.|          .|:..|     ::.:.|    ::|::| .|...:|:...||
Human   603 SLQPNKVYRVRISA----------GTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMES 657

  Fly   621 AVVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMS---------------RSFKIDL 670
            .||........||   |.||..|:|...:..|.....:.||..               :.:::..
Human   658 LVVSWQPPPHPTQ---ISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQ 719

  Fly   671 LRPGTPYEFKLQSFNSDAASEFSAIRQARTRK----------------THEQPASSSATPV---- 715
            |.||..||.||.:||.. ...::|:.:.:|.|                .|....|:|:|.:
Human   720 LVPGRLYEVKLVAFNKH-EDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRW 783

  Fly   716 --PANKAVE------------QHQNSLYPLIAGAAGGGILL----------------------LI 744
              |....|:            ....||......::|..||:                      ..
Human   784 KKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPF 848

  Fly   745 ASLVVCLCLKRRENSQPED---------------------------------ENKPQLEHIQADF 776
            .|:|....|..|.::.|.|                                 .|..|.|| |...
Human   849 GSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEH-QWTL 912

  Fly   777 VTSA--VLGVGGHHKSGDVRRLNGVIPRMNITPNPLA--------QETASDKNRNVMELRFLPPL 831
            :|:.  :.....|....|.|....:..|..:.|.|.:        ||..||.    :::..:..:
Human   913 LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDS----LDMHSVTGI 973

  Fly   832 ANGNGNG-----NCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLPQ 891
            ..|...|     .||.  ..|.||...|           .||.::|::
Human   974 IVGVCLGLLCLLACMC--AGLRRSPHRE-----------SLPGLSSTA----------------- 1008

  Fly   892 KHDQEQLDAP-NAVLEAPSKPLPPLPKKPANGAGQNNSGLHQNGLHHAQPYHPPGTPTLMHKRLD 955
                    .| |..|.:.::..||.|  ||  |.:..|.:|.    |.|.:.||  |:.:..|.:
Human  1009 --------TPGNPALYSRARLGPPSP--PA--AHELESLVHP----HPQDWSPP--PSDVEDRAE 1055

  Fly   956 YHQ--------------------QPPPVPPHSAYYQ-QAPTHQPSPMMERSVRGHQQPGG----- 994
            .|.                    ||..:....::.. :.|...|.|.:.|::   ..|.|
Human  1056 VHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGPRPALTRAL---LPPAGTGQTL 1117

  Fly   995 ------FHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNNN---NNNLPPHHQHL 1050
                  :...:|.......|:.|.|  ......||:..|..|.....|..:   .:.|||....|
Human  1118 LLQALVYDAIKGNGRKKSPPACRNQ--VEAEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDL 1180

  Fly  1051 HHHPGHPG--------GLVGIPI-VPGSPRVQRSPMPSRA 1081
            ....|.||        .|.|..: .||..|:...|..:.|
Human  1181 ISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCLPEAASA 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	30/105 (29%)
		IG_like	154..234	CDD:214653	26/88 (30%)
		Ig	172..234	CDD:299845	22/65 (34%)
		IG_like	249..329	CDD:214653	20/85 (24%)
		Ig	257..329	CDD:299845	19/77 (25%)
		IG_like	339..418	CDD:214653	21/80 (26%)
		Ig	352..408	CDD:299845	19/57 (33%)
		FN3	470..592	CDD:238020	35/186 (19%)
		FN3	613..700	CDD:238020	25/101 (25%)
IGDCC4	XP_016877937.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010