DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and palld

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_021324295.1	Gene:	palld / 557660	ZFINID:	ZDB-GENE-041014-252	Length:	1401	Species:	Danio rerio

Alignment Length:	1037	Identity:	189/1037 - (18%)
Similarity:	305/1037 - (29%)	Gaps:	334/1037 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GALVLDTVTAKDAGNYSCVATNS-ITGDELRLPQTI--ELRVDYTDRTPPYFLQRPPIE------ 251
            |.:.:||:...::|:......:: ::.||:.|...:  |...|..|...|    :||:.
Zfish    41 GEVYMDTMAELESGDGDFPELSAFLSQDEINLSLDLAREAMSDVDDPNDP----KPPVPTEHLPL 101

  Fly   252 YS----------------ARPGETVVLE------CPGVGSPRPRVIWSSPNVVEIY-NNRSTILS 293
            ||                |..|:....:      |....||...|...|  :..:| .:|..::.
Zfish   102 YSETKDHALPDSASHSVDATSGKVASSQSRQNHLCAASESPEKFVCQKS--IAPVYKQDRPRLIH 164

  Fly   294 YGLQITD----------------------------VKP---EDQGSYICMLDNGIAPPIDHTIKL 327
            .||::.:                            |.|   ||..|    .|:|...|..|.:.:
Zfish   165 GGLELNERAASATEFCSRAATFIEELSSIFKGSARVDPQGDEDSSS----PDSGYLSPKSHRLAM 225

  Fly   328 SVLQRPT------------ILRGPA----------------------------ATLTNESNPLLL 352
            ...|.|:            :|:|.|                            :....|.:|:.|
Zfish   226 QQAQPPSSSSSSSEPQQEGVLQGQADVGSGELQGGGVSLDGPVAPPRFTQKLKSQEVAEGSPIRL 290

  Fly   353 DCSASGNPQPDIYWLINGEDATKDPEAVV----DNRSLQLKRVQKRHAGVVQCFAKNILGETSEG 413
            :|..:|||.|.:.|...|.:....|:..:    |..:|.:....:...|...|.|.|.||.
Zfish   291 ECRVTGNPLPLVRWFCEGRELHHCPDIQICRDGDLHTLVITEAFEDDTGRYTCVASNALGA---- 351

  Fly   414 NILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSG-GSKNKSGRRKFKASMVPPSRPNVT 477
                          |....||.:       .|..:|.:.| ||.:||     ::..:|.::
Zfish   352 --------------DNTSAEVYI-------EGASSSDSEGEGSVSKS-----RSGAMPQAQ---- 386

  Fly   478 RLSDESVMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHW 542
                         .:.|.:.:|.                  .|:|...|....|.|...|
Zfish   387 -------------KKTSSVSLTI------------------HTSSPKSPEAQPHRSTLVQ----- 415

  Fly   543 RARNRDREYEMGNPPKNFTSSVTGLTAGKYYRF---RIVAVYSNNDNKEGNTSLKFFLQNGTSKS 604
                     .:...|:...|.|:.|.||.....   ....|..:....||    :..:.....:.
Zfish   416 ---------PISTTPQRVQSPVSSLYAGDALAKAPPSFTKVLQDAQPSEG----QVVVLECRVRG 467

  Fly   605 NLP--VPELREVETLSESA--VVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMSRS 665
            :||  |...||.:.:.:|.  .:|.....|:.:.|:|.....    |::..|      |||:
Zfish   468 SLPLRVQWFREGQEIQDSPDFRILQKKPRSAAEPEEICTLVI----AEAFPE------DGGL--- 519

  Fly   666 FKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSLYP 730
                              |...|.:|:.::...         |..:.|||    |.|...|
Zfish   520 ------------------FCCTATNEYGSVNST---------AQLTVTPV----AEEMPTN---- 549

  Fly   731 LIAGAAGGGILLLIASLVVCLCLKRRENSQPEDENKPQLEHIQADFVTSAVLGVGGHHKSGDVRR 795
               |.:|...:.              |::|......|.|.........|.:........|.:..:
Zfish   550 ---GVSGDESVF--------------EDNQSFPPPPPPLPPPPPPIEISLLEVPPKTPPSAEAFQ 597

  Fly   796 LNGVIPRMNITPNPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERSNAEEQQDEDG 860
            :|    .::|.|:..|.......::...|.|...||.||.     ..:.|....|:....::...
Zfish   598 IN----ELDIWPSVTALPVQVSTDKKPEESRPNKPLQNGQ-----FTKPLDESLSSPSSVKETAA 653

  Fly   861 HEDEKG------LPAVASSSCETLEACDAAIKLN---LPQKHD-----QEQLDAPNAVLEAPSKP 911
            ......      ||..........:|.|.:.:.|   |.|..|     |:||.||..| ..||.|
Zfish   654 PPPSPSAVRAPPLPTKPKPKLSNEQADDVSNERNAVQLKQLQDQILLEQQQLPAPQEV-SPPSPP 717

  Fly   912 LPPLPKKPANGAGQNNSGLHQNGLHHAQPYH-----------------------PPGTPTLMHKR 953
            |||    |.:.....:|.:..:..::|:|..                       .|.:||..||.
Zfish   718 LPP----PPSFQELESSTMQTSTFNYARPKQFIAAQSPTTSGAPIGYSSQSSSSSPLSPTTSHKP 778

  Fly   954 LD------YHQQPPPVPPHSAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPTRIPSLRR 1012
            ..      :||||......|.....:|:..|.|....|......|.|...|...|.|...|.:..
Zfish   779 FSRVSLPPFHQQPLLSKSSSVESPSSPSFPPPPPPFLSSSNLSSPAGLPQEFPLPPPPPPPPVTS 843

  Fly  1013 QRRTSGNQQVHNSHSNLNIGLSHHNNNNNNLPPHHQHLHHHPGHPGGLVGIP--IVPGSPRV 1072
            ....|.......|..:...|...........||....|....|:  |.|.:|  ..|.:||:
Zfish   844 SPTRSDTSSPFTSTPHSPAGFLASVLPTTPPPPPMNALGLPKGN--GTVALPRKTTPRTPRI 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653
		IG_like	154..234	CDD:214653	8/40 (20%)
		Ig	172..234	CDD:299845	8/40 (20%)
		IG_like	249..329	CDD:214653	23/139 (17%)
		Ig	257..329	CDD:299845	19/109 (17%)
		IG_like	339..418	CDD:214653	20/110 (18%)
		Ig	352..408	CDD:299845	15/59 (25%)
		FN3	470..592	CDD:238020	18/124 (15%)
		FN3	613..700	CDD:238020	14/88 (16%)
palld	XP_021324295.1	I-set	271..358	CDD:254352	20/104 (19%)
		I-set	442..539	CDD:254352	22/140 (16%)
		I-set	1025..1111	CDD:254352
		I-set	1157..1247	CDD:254352
		Ig	1273..1347	CDD:325142
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100