DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and igdcc3

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_003199017.2	Gene:	igdcc3 / 555947	ZFINID:	ZDB-GENE-080303-24	Length:	773	Species:	Danio rerio

Alignment Length:	951	Identity:	197/951 - (20%)
Similarity:	316/951 - (33%)	Gaps:	293/951 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ASDSNSSVATTLGVL--------------FERAPESAVAPKGDEVVFECEL-NLKPDRLEWRFRR 72
            ||........:||:|              |...|...:|.:...::..|:: .:.|...:||...
Zfish     2 ASGRRRQAPCSLGILLLAFVGLTCGAELSFTLEPSDIIAVQQQPLMLHCQVEGIPPISTQWRRSG 66

  Fly    73 GDSSEPYLYLRPSAGYNVTSGS-----------DGLAWRLRIYVSAQTAGDYQCVAWYGPGALAS 126
            ....|.:.|:.      .|:||           ||          :...|||:|:|....|.:.|
Zfish    67 ALVQEDHNYVM------FTNGSLLITHFQKIKTDG----------SSDEGDYECIAQNFFGLVVS 115

  Fly   127 TPARLALV----------SIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRN 181
            ..||:...          |:..|||            .|....|      .:...|..:.|:.|:
Zfish   116 RKARVQAATMADFHVQPESVRADVG------------GVGRFQC------QIHGLPEPVISWERD 162

  Fly   182 GKKLPQSE----LLPGAAGALVLDTVTAKDAGNYSCVATNS------------ITGDELRL---- 226
            |:.:..|:    |||  .|.|.:..|..:|:|.|.|||.||            ::|.:..:
Zfish   163 GRPVDTSDERFTLLP--TGVLQITGVRPEDSGVYCCVAHNSAGVKHSAGAQLTVSGSQSSVYKEP 225

  Fly   227 -----PQTIELRVDYTDRTPPYFLQRPPIEYSARPGETVVLECPGVGSPRPRVIWSSPNVVEIYN 286
                 |:.:.|.|.                      :|.:|||...|.|||.|.||..:...|..
Zfish   226 MILVGPENLTLTVH----------------------QTAILECVATGYPRPIVSWSRLDGRPIGV 268

  Fly   287 NRSTILSYG-LQITDVKPEDQGSYICMLDNGIAPPIDHTIK-LSVLQRPT-ILRGPAATLTNESN 348
            ....:|..| |.|:||:.:..|.|:|.. |.....:..|.: |.|:|.|. .::.|.:.......
Zfish   269 EGIQVLGTGNLMISDVRVQHSGVYVCAA-NKPGTRVRRTAQGLLVVQAPAEFVQPPQSIARPVGT 332

  Fly   349 PLLLDCSASGNPQPDIYWLINGEDATKDPEAVV----DNRSLQLKRVQKRHAGVVQCFAKNILGE 409
            ..:..|.|.|.|.|.|.||.||:  ..:|:..|    :|.:|.:..|.:....:.||.|:|..|.
Zfish   333 TAIFTCLAQGEPVPQITWLKNGQ--ILEPDGHVKLRNNNSTLTIYGVTQEDEAIYQCIAENSAGS 395

  Fly   410 TSEGNILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRP 474
            |.....|.|                 :|.  :...||                        |:..
Zfish   396 TQASARLTV-----------------LWA--DGLPGM------------------------PTDI 417

  Fly   475 NVTRLSDESVMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGN 539
            ....||..|:.:.|..|..:...|..:.:..|             .|:|.:
Zfish   418 QADALSPTSIQVTWKEPTQNTQDIIGYVLHIR-------------KTADPV-------------- 455

  Fly   540 SHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKS 604
                    :.||:...........:..|.....|.|.:.|..|...:|...|:::      ::..
Zfish   456 --------EMEYQEAVSKMTLQQVIGDLEPSTSYSFYVKAYTSRGASKASETTVE------STLG 506

  Fly   605 NLPVPELREVETLSESAVVLHWSLVSSTQNEDIDGYYAYYR--PADSAAEYLKATVDGGMSRSFK 667
            .:|.|.....:.::.:.:...|.  :||:....:|:..|||  |.......|....|   ...:.
Zfish   507 EVPAPPALFTKVINLTVIQATWE--ASTKMGQQEGFNLYYRKVPVPQFTGPLTFPRD---VMQYN 566

  Fly   668 IDLLRPGTPYEFKLQSFN----SDAASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSL 728
            |..|.|...||.|:.:||    .:|...|.::::|..:       |...||....|. ||:::|.
Zfish   567 ITQLDPSFVYEIKILAFNQHGEGNATLRFVSLKEAVEK-------SVLNTPCDCVKD-EQNKSST 623

  Fly   729 YPLIAGAAGG------GILLLIAS----LVVCLCLKRRENSQPEDENKPQLEHIQADFVTSAVLG 783
            ..:|.|...|      .:|.|:.|    |::|   |..:.|:....|......:::.....|:.|
Zfish   624 TGIIIGIHIGVTCIIFCVLFLMFSYRGRLMMC---KTVQASRQAGRNPAAGVVLESSSSQGALSG 685

  Fly   784 V--------GGHHK------SGDVRRLNGVIPRMNITPN------------PLAQETASDKNRNV 822
            .        ||.|.      |.::.||.......:..|:            ||          |.
Zfish   686 PHRFSPDGNGGAHNAKSCTDSNEMERLFSGPSHYSHPPDTTHTIESSLVSCPL----------NE 740

  Fly   823 MELRFLP----PLANGNGNGNCMARDLALERSNAEEQQDED 859
            .|:..||    .||.     .|   :|...|..||.|:|||
Zfish   741 TEMSTLPLDDFSLAE-----EC---ELQFCRHPAEGQRDED 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	21/100 (21%)
		IG_like	154..234	CDD:214653	24/104 (23%)
		Ig	172..234	CDD:299845	22/86 (26%)
		IG_like	249..329	CDD:214653	24/81 (30%)
		Ig	257..329	CDD:299845	24/73 (33%)
		IG_like	339..418	CDD:214653	23/82 (28%)
		Ig	352..408	CDD:299845	19/59 (32%)
		FN3	470..592	CDD:238020	18/121 (15%)
		FN3	613..700	CDD:238020	21/92 (23%)
igdcc3	XP_003199017.2	Ig1_Neogenin	30..122	CDD:143199	23/107 (21%)
		I-set	128..214	CDD:254352	25/105 (24%)
		Ig	130..214	CDD:299845	25/103 (24%)
		Ig	229..307	CDD:299845	25/100 (25%)
		IG_like	231..313	CDD:214653	27/104 (26%)
		I-set	318..404	CDD:254352	23/87 (26%)
		IGc2	331..394	CDD:197706	19/64 (30%)
		FN3	411..504	CDD:238020	21/157 (13%)
		fn3	509..589	CDD:278470	20/84 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010