DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Cdon

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_059054.2	Gene:	Cdon / 50938	RGDID:	708433	Length:	1256	Species:	Rattus norvegicus

Alignment Length:	1266	Identity:	272/1266 - (21%)
Similarity:	404/1266 - (31%)	Gaps:	476/1266 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLLVLMTTCIYTLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEW----- 68
            :|.||:..|          |||::.|...|...|.|||...|..||..|.......|:.|
  Rat    11 LLYVLVILC----------SSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGK 65

  Fly    69 ---------RFRRGDSSEPYLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGAL 124
                     :..||..:  .|.|.||                       .:|.|||||....||:
  Rat    66 RLDRNTEQIKIHRGTLT--ILSLNPS-----------------------LSGCYQCVANNSVGAV 105

  Fly   125 ASTPARLALVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPA--------IWSFYRN 181
            .|.||.::..::| |....:|...::     ..||...|.|....|||.|        .|..|..
  Rat   106 VSGPATVSAAALA-DFDSSTMHVITA-----EEKNTGFIGCRVPESNPKAEVRYKIRGKWLMYST 164

  Fly   182 GKKLPQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDR------- 239
            |..:    :||  :|.|.:..|::||.|:|.|.|.|         |.|.||:|:...|
  Rat   165 GNYI----ILP--SGNLQILNVSSKDKGSYKCAAYN---------PVTSELKVEPAGRKLLVSRP 214

  Fly   240 -TPPYFLQRPPIE--YSARPGETVVLECPGVGSPRPRVIW--------SSPNVVEIY-------- 285
             :..:.:..|.:.  .:..|...|.|||...|.|..:|.|        |..|...:|
  Rat   215 SSDGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDALSGSNWRRLYSHLATASI 279

  Fly   286 -------------NNRS----------TILSYG-------------------------------- 295
                         ||||          .:|.:.
  Rat   280 DPADSGNYSCVVGNNRSGDVKHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCEVHGNPAPNRT 344

  Fly   296 --------------------LQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVL----QRPTIL 336
                                |:||.|..||.|.|.||.||||. .:..|.:|.:.    |||.|:
  Rat   345 WFHNAQPIRPSSRHLTEGSVLKITGVIMEDSGLYQCMADNGIG-FMQSTGRLQIEQDSGQRPVIV 408

  Fly   337 RGPAATLTNESNPLLLDCSASGNPQPDIYW-----LINGEDA----------------TKDPEAV 380
            ..||.....:.:.:.|.|:|:|.|.|.|:|     ||....:                ..|||.|
  Rat   409 TAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKSHLFRPGDLDPEPV 473

  Fly   381 ------VDNRSLQLKRVQKRHAGVVQCFAKNILGET----------------------------- 410
                  ..:.||.::.|...|||...|.|.|..|.|
  Rat   474 YLIMSQAGSSSLSIQAVTWEHAGKYTCEAVNKHGSTQSEAFLTVVPFETNTKAEPVTPSEASQND 538

  Fly   411 -------SEGNILRVNPLEI--------------------------------------TGED--- 427
                   ||..:|.:.|:::                                      .|.|
  Rat   539 ERDPRDGSESGLLNLFPVKVHSGGVELPAEKNASVPDAPNILSPPQTHMPDTYTLVWRAGRDGGM 603

  Fly   428 ------------DEPLGEVPVW-------------------------------PVHESNTGMGTS 449
                        |:..|.|..|                               .|.|....|.|.
  Rat   604 PINAYFVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTF 668

  Fly   450 STS----GGSKN-----------------KSGRRKF--------KASMVP--PSRPNVTRLSDES 483
            .||    ..|||                 ::....|        :.|.||  |.||.::..|:.|
  Rat   669 RTSKEKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETS 733

  Fly   484 VMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRD 548
            |.:.|....|.|..||.|||:|:.:     :..:|...:::|
  Rat   734 VYVTWIPRANGGSPITAFKVEYKRM-----KSSDWLVAAEDI----------------------- 770

  Fly   549 REYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSK-SNLPV--PE 610
                   ||...:..|..|..|..|:||::|:....::...:.|..:.:....:: ||.|:  |.
  Rat   771 -------PPSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPH 828

  Fly   611 LREVETLSESAVVLHWSLV-SSTQNEDIDGYYAYYRPADS--AAEYLKATVDGGMSRSFKIDLLR 672
            :...|.:|::.::|.|:.: ||..|..|.|:|.||||.||  .::|.:..|:|. .:...|..|:
  Rat   829 IAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGS-KQWHTIGHLQ 892

  Fly   673 PGTPYEFKLQSFNSDAASEFSAIRQARTR------------KTHEQPASSSATPVPANKAVEQHQ 725
            |.|.|:.|:|.||....||||.:....|:            |....|.|||........|....:
  Rat   893 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATSPAR 957

  Fly   726 NS--LYPLIAGAAGGGILLLIASLVVCLCLKRRENS-----------QPEDENKPQLEH------ 771
            :|  ||.::....|..:|:|:..:.:||...|::::           |..:.|...:|:
  Rat   958 SSDMLYLIVGCVLGVMVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGT 1022

  Fly   772 ------IQADFVTSAVLGVGG---HHKSGDVRRLNGVIPRMNITPN-PLAQETASDKNRNVMELR 826
                  :...|::...|..|.   |||..     |||...:|.|.| .|.....|...|..:|..
  Rat  1023 ARINGSVHGGFLSKGSLSNGCSHLHHKGP-----NGVNGILNGTINGGLYSAHTSSLTRTCVEFE 1082

  Fly   827 FLPPLANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLP- 890
            ....|.||..            ...|..|.|.        |..:...:|.....|.......||
  Rat  1083 HPHHLVNGGA------------VYTAVPQMDP--------LECINCRNCRNNNRCFTKTNSPLPV 1127

  Fly   891 ----QKHDQEQLD-APNAVLEAPSKPLPPLP 916
                ..:.|:.|: .|..|::.|..|:..:|
  Rat  1128 VPVVASYPQDGLEMKPLGVMKFPVCPVSTVP 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	27/102 (26%)
		IG_like	154..234	CDD:214653	27/87 (31%)
		Ig	172..234	CDD:299845	21/69 (30%)
		IG_like	249..329	CDD:214653	33/172 (19%)
		Ig	257..329	CDD:299845	32/162 (20%)
		IG_like	339..418	CDD:214653	30/141 (21%)
		Ig	352..408	CDD:299845	23/82 (28%)
		FN3	470..592	CDD:238020	27/123 (22%)
		FN3	613..700	CDD:238020	32/89 (36%)
Cdon	NP_059054.2	Ig	28..113	CDD:416386	28/109 (26%)
		Ig strand A	28..31	CDD:409353	0/2 (0%)
		Ig strand B	45..52	CDD:409353	3/6 (50%)
		Ig strand C	57..62	CDD:409353	2/4 (50%)
		Ig strand C'	65..67	CDD:409353	0/1 (0%)
		Ig strand D	73..77	CDD:409353	0/3 (0%)
		Ig strand E	79..83	CDD:409353	1/5 (20%)
		Ig strand F	92..100	CDD:409353	6/7 (86%)
		Ig strand G	103..113	CDD:409353	5/9 (56%)
		Ig	120..196	CDD:416386	24/95 (25%)
		Ig strand A	120..123	CDD:409353	0/2 (0%)
		Ig strand B	133..144	CDD:409353	4/10 (40%)
		Ig strand C	149..155	CDD:409353	1/5 (20%)
		Ig strand C'	157..160	CDD:409353	0/2 (0%)
		Ig strand D	167..171	CDD:409353	0/7 (0%)
		Ig strand E	173..179	CDD:409353	2/5 (40%)
		Ig strand F	185..194	CDD:409353	4/8 (50%)
		IGc2	236..294	CDD:197706	11/57 (19%)
		Ig strand B	238..242	CDD:409353	2/3 (67%)
		Ig strand C	251..255	CDD:409353	1/3 (33%)
		Ig strand F	286..291	CDD:409353	0/4 (0%)
		Ig strand G	300..303	CDD:409353	0/2 (0%)
		Ig	320..397	CDD:416386	16/77 (21%)
		Ig strand A'	320..324	CDD:409353	0/3 (0%)
		Ig strand B	327..337	CDD:409353	0/9 (0%)
		Ig strand C	342..348	CDD:409353	0/5 (0%)
		Ig strand C'	349..352	CDD:409353	0/2 (0%)
		Ig strand E	363..369	CDD:409353	2/5 (40%)
		Ig strand F	376..384	CDD:409353	4/7 (57%)
		Ig strand G	387..397	CDD:409353	2/10 (20%)
		I-set	405..517	CDD:400151	29/111 (26%)
		Ig strand A'	413..417	CDD:409353	0/3 (0%)
		Ig strand B	421..429	CDD:409353	2/7 (29%)
		Ig strand C	435..457	CDD:409353	4/21 (19%)
		Ig strand C'	460..463	CDD:409353	0/2 (0%)
		Ig strand D	471..479	CDD:409353	2/7 (29%)
		Ig strand E	482..488	CDD:409353	2/5 (40%)
		Ig strand F	496..504	CDD:409353	3/7 (43%)
		Ig strand G	507..517	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..550		2/27 (7%)
		fn3	588..663	CDD:394996	8/74 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..696		4/24 (17%)
		FN3	718..808	CDD:238020	27/124 (22%)
		FN3	833..920	CDD:238020	32/87 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..952		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1174..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102649at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920