DRSC/TRiP Functional Genomics Resources

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Protein Alignment boi and NEO1

DIOPT Version :9

Sequence 1:NP_001096868.3 Gene:boi / 31229 FlyBaseID:FBgn0040388 Length:1105 Species:Drosophila melanogaster
Sequence 2:XP_005254465.1 Gene:NEO1 / 4756 HGNCID:7754 Length:1481 Species:Homo sapiens


Alignment Length:1471 Identity:282/1471 - (19%)
Similarity:463/1471 - (31%) Gaps:485/1471 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 SSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPD-RLEWRFRRGDSSEPYLYLRPSAGYNVT 91
            :|:.|.....|...|...::.:|..|:..|....:|. ::||:             :.....|:.
Human    45 ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWK-------------KDGTFLNLV 96

  Fly    92 SGS------DGLAWRLRIYVSAQTAGD---YQCVAWY-GPGALASTPARLALVSIALDVGQGSMG 146
            |..      ||..:...:..|.....|   |||||.. ..|.:.|..|:|.:..:.....|....
Human    97 SDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161

  Fly   147 ARSSIRWSVAPKNCLLIRCGSVISNPPAI-WSFYRNGKKLPQSEL-LPGAAGALVLDTVTAKDAG 209
                   ||...|..::.|.......|.: |...|....|....: ||  :|.||:...|..|.|
Human   162 -------SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLP--SGMLVISNATEGDGG 217

  Fly   210 NYSCVATNSITGDELRLPQTIELRV--DYTDRTPPYFLQRP-PIEYSARPGETVVLECPGVGSPR 271
            .|.||..   :|...:....:||:|  |....:...||::| |:....  |:.|||.|...|.|.
Human   218 LYRCVVE---SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVI--GQDVVLPCVASGLPT 277

  Fly   272 PRVIW-SSPNVVEIYNNRSTILSYG--LQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVLQRP 333
            |.:.| .:...::..::...:|..|  |:|:||..:|.|:|.|:.||| ...|:...:|:|..:|
Human   278 PTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG-NETIEAQAELTVQAQP 341

  Fly   334 TILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDA-TKDPEAVVDNRSLQLKRVQKRHAG 397
            ..|:.|.....:||..::.:|..:|.|.|.:.|:.||:.. ..|...:|...:||:..:.|...|
Human   342 EFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEG 406

  Fly   398 VVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSGGSKNKSGRR 462
            ..||.|:|.:|....|..|      |..|.|..:..:|...:..:.|.....:|:|  ...|..|
Human   407 FYQCIAENDVGNAQAGAQL------IILEHDVAIPTLPPTSLTSATTDHLAPATTG--PLPSAPR 463

  Fly   463 KFKASMVPPSRPNVTRLSDESVMLRWSVPQNS--GLQITFFKVQYRMLGDGKNRRKN------WQ 519
            ...||:|          |...:.|.|..|.:.  |..:| :.|.|...|..:.|.:|      .|
Human   464 DVVASLV----------STRFIKLTWRTPASDPHGDNLT-YSVFYTKEGIARERVENTSHPGEMQ 517

  Fly   520 TTSDN----------IPYGNAHGSG---------------------------------------P 535
            .|..|          :...|.||||                                       |
Human   518 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP 582

  Fly   536 GQGNS-------HWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSL 593
            ..||.       ::..:..|:|.::.....::|  :.||.....|.||:||.     ||.|    
Human   583 VSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYT--INGLKKYTEYSFRVVAY-----NKHG---- 636

  Fly   594 KFFLQNGTSKSNLPVPELREV----------ETLSESAVVLHWS-LVSSTQNEDIDGYYAYYRPA 647
                 .|.|..::.|..|.:|          |..:..::::||. ...:|||..|.||...||.|
Human   637 -----PGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA 696

  Fly   648 DSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQART-------RKTHE 705
            ...:: :..|:..|...|..|:.|..||.|.|::.:...:.....:....|.|       .:..|
Human   697 SRKSD-VTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPE 760

  Fly   706 QPASSSATPVPANKAVE----QHQNSLYPLIAG-AAGGGILLLIASLVVCLCLKRR----ENSQP 761
            .|:|....|:..:..|.    ::||.   ::.| |.|.||....|. .:.:..|:|    ||..|
Human   761 VPSSLHVRPLVTSIVVSWTPPENQNI---VVRGYAIGYGIGSPHAQ-TIKVDYKQRYYTIENLDP 821

  Fly   762 EDE----------------------NKPQLEHIQAD-FVTSA-------------VLGVGGHHKS 790
            ...                      .:|..:..:.| ||.:|             .:||.....|
Human   822 SSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILS 886

  Fly   791 GDVRRL----NGVIPRMNIT-----------------------------------PNPLAQ---- 812
            .|..|:    |.:.....||                                   ||.|.:    
Human   887 HDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVM 951

  Fly   813 ----------------------ETASDKNRNVME---------LRFLPPL-ANGNGNG------- 838
                                  .|:..|:..|:.         :.:.||. |||...|       
Human   952 VTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYST 1016

  Fly   839 --NCMARDLALER--SNAEEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLPQKHDQEQLD 899
              |....|..:|.  .|....|.::...|......:.:.:.:.:.....|::...|:....::  
Human  1017 DVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDK-- 1079

  Fly   900 APNAVLEAPSKPLPPLPKKPANGAGQNNSGLHQNGLHHAQPY----HPPGTPT------------ 948
                           :|...|:|:|...|.|...|..:..|.    .|.|:||            
Human  1080 ---------------MPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVII 1129

  Fly   949 ----------------LMHKRLDYHQ-----------------------QPPPVPPHSAYYQQAP 974
                            ...:|...||                       :||.:..|....:..|
Human  1130 VSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKP 1194

  Fly   975 ---THQPSPMM--------------------------ERSVRGHQ-------------------- 990
               :..|:|:|                          ..|.|||:                    
Human  1195 IDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMM 1259

  Fly   991 ----------------------------------------QPG-----GFHME-----------E 999
                                                    .||     |..|.           .
Human  1260 PFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVR 1324

  Fly  1000 GTPTPTRIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNNNNNNLPPHHQHLHHHPGHPGGLVGIP 1064
            .||:...:|:...|...:.:|....:.|:..:..|...::..:||.    .|..|.||.....:|
Human  1325 NTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPT----AHVRPSHPLKSFAVP 1385

  Fly  1065 IV--PGSPRVQRSPMPSRAMIKRTRLGSHTDNISSGSLNSI 1103
            .:  ||.|....: :||..::.:..|..|..::.:.|:.::
Human  1386 AIPPPGPPTYDPA-LPSTPLLSQQALNHHIHSVKTASIGTL 1425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
boiNP_001096868.3 IG_like 42..131 CDD:214653 21/99 (21%)
IG_like 154..234 CDD:214653 22/81 (27%)
Ig 172..234 CDD:299845 18/63 (29%)
IG_like 249..329 CDD:214653 25/82 (30%)
Ig 257..329 CDD:299845 24/74 (32%)
IG_like 339..418 CDD:214653 23/79 (29%)
Ig 352..408 CDD:299845 17/56 (30%)
FN3 470..592 CDD:238020 35/185 (19%)
FN3 613..700 CDD:238020 23/97 (24%)
NEO1XP_005254465.1 Ig1_Neogenin 54..148 CDD:143199 23/106 (22%)
IG_like 59..148 CDD:214653 22/101 (22%)
Ig_2 157..239 CDD:290606 23/93 (25%)
IG_like 158..239 CDD:214653 22/92 (24%)
I-set 250..337 CDD:254352 28/89 (31%)
IGc2 262..326 CDD:197706 22/66 (33%)
I-set 341..427 CDD:254352 25/91 (27%)
Ig4_Neogenin 357..427 CDD:212460 20/75 (27%)
FN3 459..552 CDD:238020 24/103 (23%)
FN3 559..648 CDD:238020 19/104 (18%)
FN3 656..748 CDD:238020 22/92 (24%)
FN3 759..838 CDD:214495 18/82 (22%)
FN3 876..969 CDD:238020 11/92 (12%)
FN3 976..1071 CDD:238020 15/94 (16%)
Neogenin_C 1178..1481 CDD:284094 37/253 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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