DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and tutl

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	1314	Identity:	266/1314 - (20%)
Similarity:	434/1314 - (33%)	Gaps:	394/1314 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YTLQASDSNSSVATTLGVLFERAPESAVAP------KGDEVVFECELNLKPDRLEWRFRRGDSSE 77
            ||..|.:....|:.|..|:........|.|      :|::|:|.||....|..:..|:.|..|.
  Fly   322 YTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSP- 385

  Fly    78 PYLYLRPSAGY--NVTSGSDGLAWRLRIY-VSAQTAGDYQCVAWYGPGALASTPARLALVSIALD 139
                :|..|..  .||...||   .|.|. :....:|.|.|....|.|...|..|.|::
  Fly   386 ----VREVAALETRVTIRKDG---SLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSV------ 437

  Fly   140 VGQGSMGARSSIRWSVAPKNCLLIRCGSVI-----SNPPAIWSFYRNGKKL----PQSELLPGAA 195
                ...|:.:...:|   ..|..|...|:     |:|...:..:...|:|    ...:::..|.
  Fly   438 ----EYPAKVTFTPTV---QYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMAN 495

  Fly   196 GALVLDTVTAKDAGNYSCVATNS-----ITGDELRLPQTIELRVDYTDRTPPYFLQRPPIEYSAR 255
            |:|:...|..:..|.|:|...|:     .:|           .:|...|.||.|...|...|..:
  Fly   496 GSLLFTRVNEEHQGQYACTPYNAQGTAGASG-----------VMDVLVRKPPAFTVEPETLYQRK 549

  Fly   256 PGETVVLECPGV---GSPRPRVIW---SSPNVVEIYNNRSTILSYGLQITDVKPEDQGSYICMLD 314
            .|::|.:.|..:   |:.||.:.|   ....:.|...||..|....:.|.:::.||.|.|.|::.
  Fly   550 VGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVS 614

  Fly   315 NGIAPPIDHT---IKLSVLQRPTILRGPAATLTNESNPLL--LDCSASGNPQPDIYWLINGEDAT 374
            |.:|..:..|   |:.:....|..:.|.|    .||:..|  |...:.|:.....|.:...|...
  Fly   615 NEVATLMAVTQLVIEGTQPHAPYNITGKA----TESSITLQWLPGYSGGSEYKQDYTIWFREAGV 675

  Fly   375 KDPE--AVVDNRSLQLKRVQKRHAGVV---QCFAKNILGETSEGNILRVNPLEITGEDDEPLGE- 433
            .|.:  :|..:.|.|: .:....:|..   |...:|:||:.....::.|..||     |.|...
  Fly   676 NDWQTISVTPSGSTQV-TINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLE-----DAPAAPR 734

  Fly   434 ----------------------VPVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNV 476
                                  :..:.::......||...|.......|.:.     .||...:|
  Fly   735 NVKAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKP-----GPPRNVSV 794

  Fly   477 TRLSDESVMLRWSVPQNSGLQITFFKVQYR------MLGDGKNRRKNWQTTSDNIPYGNAHGSGP 535
            |.:|: ..::.|..|......:.|:.::||      .|..|:.|.:..|....|:..|..:
  Fly   795 TEVSN-GFLITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTY---- 854

  Fly   536 GQGNSHWRA-RNRDREYEMGN------PPKNFTSSVT-GLTAGKYYRFRIVAVYSN-------ND 585
                 ::|. .|.::.||..:      |.:....::| |:..|  ..|.|||:..:       |.
  Fly   855 -----YFRVLANSEKSYESSDEVKFPVPARVKHKAITAGVVGG--ILFFIVAIILSVCAVKICNK 912

  Fly   586 NKEGNTSLKF------------------FLQN----GTSKSNLPVPELREVETLSESAV---VLH 625
            .|......:|                  .|.|    ..|...:|:.:.::....|.:|:   :||
  Fly   913 RKRRKQEKEFNMVACRITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILH 977

  Fly   626 W-----------SLVSSTQNED--------------------IDGYYAYYRPADSAAEYLKATVD 659
            |           |:.||...||                    :||.:.......|...|.:.|::
  Fly   978 WIWPPDRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLE 1042

  Fly   660 GGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQAR----TRKTHEQP--ASSS------- 711
            .|     .:|::..|. :|.:..:.:..::|:.......|    .|.:..:|  ||||
  Fly  1043 SG-----NVDVVDGGL-FERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSA 1101

  Fly   712 -----------------ATPVPAN------KAVE--QHQNSLYPL-----IAGAAG--------- 737
                             .:.||.|      :||.  ::||.|.|.     :.|.|.
  Fly  1102 ADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINT 1166

  Fly   738 -GGILLLIASLVVCLCLKRRENSQPEDENKPQLE-HIQADFVTSAVLGVGGHHKSGDVRRLNGVI 800
             .|.|.....|.....:.|..:|.|:     ||: |.|...::|...|....|.|.    |:.|.
  Fly  1167 ISGSLSQQQQLYTPSRISRIFSSSPQ-----QLQPHHQQLLLSSGGSGAYPTHFSD----LSTVY 1222

  Fly   801 PRMNITPNPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERSNAEEQQDEDGHEDE- 864
            |     ||...:.:.:..:|.....:.||.|..            ..|.:..::||.:...||.
  Fly  1223 P-----PNSAERSSHNLSSRYRYYSQELPSLRT------------IQEETRRQQQQKQHPLEDHF 1270

  Fly   865 KGLPAVASSSCETLEACDAAIK--------------LNLPQKHD------QEQLDAPNAV----L 905
            ..|...:..|..:.....|:.:              .|..|:|:      |..|:..|::    |
  Fly  1271 VPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPGGL 1335

  Fly   906 EAPSKPLPPLPKKPANGAGQNNSGLHQNGLHH---AQPYHPPGTPTLMHKRLDYH--QQPPPVPP 965
            ||     .|..:..::|.|..|:..|......   ..||..|.:|.   |...|.  ||.....|
  Fly  1336 EA-----SPESRSSSSGFGSKNTSNHPGSTSEWRLLPPYRAPPSPP---KHSGYFGGQQAQGQTP 1392

  Fly   966 HSAY-YQQAPT------------------------HQPSPMMERSVRGHQQPGGFHMEEGTPTPT 1005
            |.:| |.:|.|                        ..|.|:...||.||     :..:..||||:
  Fly  1393 HGSYSYPRATTPPYTMAHWLEMISRLNAATDSNLPKAPCPVDVGSVDGH-----YEFDPATPTPS 1452

  Fly  1006 RIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNNNNNNLPPHHQH---------LHHHPGHPGGLV 1061
            ....||               .:||:.:..|        |:|.|         ||.|..:.||
  Fly  1453 ASSMLR---------------EDLNLHIDTH--------PYHHHTLGPLSGSLLHSHAPYGGG-- 1492

  Fly  1062 GIPIVPGSPRVQRS 1075
                    .|.|||
  Fly  1493 --------ARKQRS 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	26/97 (27%)
		IG_like	154..234	CDD:214653	17/93 (18%)
		Ig	172..234	CDD:299845	12/70 (17%)
		IG_like	249..329	CDD:214653	22/88 (25%)
		Ig	257..329	CDD:299845	21/80 (26%)
		IG_like	339..418	CDD:214653	17/85 (20%)
		Ig	352..408	CDD:299845	11/60 (18%)
		FN3	470..592	CDD:238020	30/142 (21%)
		FN3	613..700	CDD:238020	21/124 (17%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	6/18 (33%)
		IGc2	268..331	CDD:197706	3/8 (38%)
		I-set	346..437	CDD:254352	27/98 (28%)
		Ig	349..437	CDD:299845	27/95 (28%)
		Ig	459..530	CDD:299845	14/81 (17%)
		IG_like	549..628	CDD:214653	20/78 (26%)
		IGc2	551..617	CDD:197706	18/65 (28%)
		FN3	633..725	CDD:238020	20/96 (21%)
		FN3	786..874	CDD:238020	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840