DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and plum

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	1224	Identity:	238/1224 - (19%)
Similarity:	398/1224 - (32%)	Gaps:	397/1224 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IRLVVVLLVLMTTCIYTLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEW 68
            |:|:.:||:|:|.....|..:..:::||            :|||...:....:..|.::...:.
  Fly    12 IQLIEILLLLLTDHNGRLTLTKESTTVA------------AAVAQPKNSTALQPYLQIQKHAVT- 63

  Fly    69 RFRRGDSSEPYL-----YLRPSAGYNVTSGSDGL--AW-----------------------RLRI 103
            |........||.     .|.|   ||....:..:  :|                       .||:
  Fly    64 RLTISKPHSPYYLPCIPILTP---YNHDQDNQPIYCSWYRNDVVVEQVSYRKNDFFIYDNGTLRL 125

  Fly   104 YVSAQTAGDYQC-VAWYGPGALASTPARLALVSIALDVGQGSM-----GARSSIRWSVAPKNCLL 162
            ..:.:.:|:|.| :.|          ...|::|..:.|....:     |.:.:...|......|:
  Fly   126 PTNEKASGEYYCKIEW----------DESAVISDRITVEYPVLKRLFPGQQQAANISALENKPLV 180

  Fly   163 IRCGSVISNPPAIWSFYRNGKKLP-QSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRL 226
            :.| ..:|.|.|.:|:|.....|. .:..|....|.|:|..:..:.||.|.|||.|:......|
  Fly   181 LSC-PFLSVPAARFSWYFGNDSLTNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHR- 243

  Fly   227 PQTI-ELRVDYTDRT--P-----------------PYFLQRPPIEYSARPGETVVLECPGVGSPR 271
             |.| :|:|:..|.|  |                 |.| |...:...|  |.:|:|:|..|....
  Fly   244 -QFIWQLQVEPKDATFYPKNEAGITETAVSEAQLLPAF-QNATVFVPA--GGSVLLQCHAVADFV 304

  Fly   272 PRVIW--SSPN--VVEIYNNRSTILSYGLQITDVK-PEDQGSYICMLDNGIAPPIDHTIKLSVLQ 331
            | ::|  ..||  :|.:.||     |....||:.. ...:|.|.|     |.|......::.|..
  Fly   305 P-IVWYLQPPNNKMVRLSNN-----SVAYSITNASIARHEGRYSC-----ITPLETQNFQVIVTT 358

  Fly   332 RPTILR---------GPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDATKDPEAVVDNRSLQ 387
            .|.|:.         |.:.|||         |.|.|:|:|.|.|..||..........:....|.
  Fly   359 PPRIVSRLPVEVVYIGLSRTLT---------CRAEGHPEPSITWYHNGVHLNSSYTRYISGNELH 414

  Fly   388 LKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWP--VHESN------- 443
            :.....:..|:.||.|:|:.||.|....||.|.   ..|:..||..:..:|  .|..|
  Fly   415 VHSFDSKEEGIYQCVARNVAGEDSATGELRFNR---QLEEVNPLQNIRCYPHSFHSINITFDSRT 476

  Fly   444 -TGM--------GTSSTSGGSKNKSGRRKFK--ASMVPPSRP--NVTRLSDESVMLRWS--VPQ- 492
             |.|        ...|.:..|..|..:..:.  ::.:|...|  .:||:...:..:|..  |||
  Fly   477 LTSMFVVYIVRNNPHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGTLVPQQ 541

  Fly   493 --------------NSGLQI--------TFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAH---- 531
                          ..||.:        ||.|     ...|:...|.:.....:|.:.:.|
  Fly   542 MILSSLRSTPVTCCTQGLMLRPIAVGNDTFVK-----WSQGQLENKKYFILQFSINHTHPHPAQL 601

  Fly   532 --GSGPGQGNSHWRARNRDREYEMGNPPKN--------------------------------FTS 562
              ||..|...|.....::.|.:.....|.|                                ..:
  Fly   602 LNGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAATVLRNVEHEDNVVDDTLELEDDIFSLVVDA 666

  Fly   563 SVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKF----FLQNGTS-KSNLP----VPELRE----- 613
            ||||:...::.|.::..:....:|:......::    .::|||| :||:|    ..|.|.
  Fly   667 SVTGILLQRFTRIKMRVLIITTENEFLGQDFRYVQWKIIENGTSEQSNMPFRLVTRESRALAFKF 731

  Fly   614 VETLSESAVV-------LHWSLVS---STQNEDI------------DGYY----------AYYRP 646
            :::|:|:.|:       ...||.|   ..|:.:|            |..|          .:|..
  Fly   732 LDSLNETCVLECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGD 796

  Fly   647 ADSAAEY--------LKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKT 703
            .|...|.        .|.....|:...::..:...|..:.:.:: ::.|..:..:.:::. |:.:
  Fly   797 IDEKTEQDPPGTISNSKLIKQNGLKLMWEPPINPNGRVHHYDIR-WSLDNVTHEAIVKEC-TKCS 859

  Fly   704 HEQPASSSATPVPANKAV-----------------------EQHQNSLYPLIAGAAGGGILLLIA 745
            ::.|..|....:.....|                       |:.::|...:.:|.|.|.:|
  Fly   860 YKFPNVSETAKIHVAVRVMGDTGAGAPMYFDMINNNHTWLKEESESSHSEVYSGIAIGSLL---- 920

  Fly   746 SLVVCLCL------------KRREN-----SQPEDENKPQLEHIQADFVTSAVLGVGGHHKSG-- 791
             .:.|:.|            |.|..     :.|.|.|...|         |:..|:.|....|
  Fly   921 -SIACVFLFGLFIIFQQRNFKARAQGPTHLTTPTDINFGNL---------SSASGMPGDSAGGLS 975

  Fly   792 ------DVRRLNGVIPR----MNITPNPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLA 846
                  |...:..:|||    :.:.|....:...|.....|:.      ||||||:.....|
  Fly   976 GGTLQQDCHEMQTLIPRSRYHIELLPEHSLEYQTSTAAVAVVH------LANGNGSVQVARR--- 1031

  Fly   847 LERSNAEEQQDEDG-----------HE-DEKGLPAVASSSCETLEACDAAIK----LNLPQKHDQ 895
                     .|:||           |. .:..|..|..:|.|.....||.::    ..:|.:|
  Fly  1032 ---------SDQDGAAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKAFYIPYRH-- 1085

  Fly   896 EQLDAPNAVLEAPSKP------------LPP--------LPKKPANGAGQNNSG 929
               ..||||..:.||.            :||        :|.....|.|.:..|
  Fly  1086 ---TPPNAVALSSSKQCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSGGG 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	18/119 (15%)
		IG_like	154..234	CDD:214653	24/81 (30%)
		Ig	172..234	CDD:299845	20/63 (32%)
		IG_like	249..329	CDD:214653	21/84 (25%)
		Ig	257..329	CDD:299845	20/76 (26%)
		IG_like	339..418	CDD:214653	22/78 (28%)
		Ig	352..408	CDD:299845	15/55 (27%)
		FN3	470..592	CDD:238020	30/186 (16%)
		FN3	613..700	CDD:238020	17/131 (13%)
plum	NP_001163744.1	IG_like	170..241	CDD:214653	20/71 (28%)
		IGc2	175..235	CDD:197706	18/60 (30%)
		IG_like	284..356	CDD:214653	21/84 (25%)
		I-set	360..443	CDD:254352	24/91 (26%)
		IGc2	378..435	CDD:197706	18/65 (28%)
		FN3	804..886	CDD:238020	8/83 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840