DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Cont

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	159/741 - (21%)
Similarity:	264/741 - (35%)	Gaps:	207/741 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ATTLGVLFERAPESAVAPKGDEVVFECELNLKP-DRLEWRFRRGDSSEPYLYLRPSAGYNVTSGS 94
            |.|...:|   ||:.||  |||:..||.....| ....|. |:|      |.|:.:| |.:..|
  Fly   572 ANTFPKVF---PEAPVA--GDEIRLECMAFGYPIPSYNWT-RQG------LPLQRNA-YTINYG- 622

  Fly    95 DGLAWRLRIYVSAQT--AGDYQCVAWYGPGALASTPARLALVSIALDVGQGSMGARSSI--RWSV 155
                 |:.|..:|.|  .|:|.|.        .:.|.:..:.||.:::   .|..:.:|  :..:
  Fly   623 -----RVLIIQNATTNDNGEYSCT--------ITNPRKTLMKSIYINI---QMRPQFTIPLKDMI 671

  Fly   156 APKNCLLIRCGSVISNPPAIWSFYRNGKKLPQSELLPGAAGALVLDTVTA-------KDAGNYSC 213
            ...|..:.......:.|.|.:::|:|.::|..:.:  .....::.|.|..       ||...|.|
  Fly   672 KDYNSDVTFICEAFAIPDANYTWYKNAERLDPANI--NRDRYIIQDNVLTIKFLEKDKDDAMYQC 734

  Fly   214 VATN----SITGDELRLPQTIELRVDYTDRTPPYFLQRPPIE---YSARPGETVVLECPGVGSPR 271
            .|.|    |.:..:||:   :.::        |.| ::.|:|   |:...|.|.:: |....:||
  Fly   735 GAQNQLKTSFSSAQLRV---LSMK--------PSF-KKHPLESEVYAVYNGNTTIV-CDPEAAPR 786

  Fly   272 PRVIWSSP-NVVEIYNNRSTILSYGLQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVLQRPTI 335
            |:..|... .|:....:|..:.|..|.|:....:|:|.|.|:..|.......|. ::.|||....
  Fly   787 PKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHA-RVIVLQEIRF 850

  Fly   336 LRGPAATLTNESNPLL-LDCSASGNPQPDI--YWLINGE------DATKDPEAVVDNRSLQLKRV 391
            :..|...:.::.:.|: |.|.|:.:...||  .|..|||      |.|  ...:||...|.:...
  Fly   851 IETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGT--GRIIVDWNRLTVHNT 913

  Fly   392 QKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSGGSK 456
            ..|.||..:|..|:.:.|.|                              |.|.:......|.
  Fly   914 SMRDAGDYECVVKSAVNEIS------------------------------SKTSVSIEGAPGA-- 946

  Fly   457 NKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTT 521
                          |....|.::|....::.|....::|..|.:    |.:||     |.||..|
  Fly   947 --------------PGGVQVIQISKTKAIIEWVDGSHNGRAIRY----YNILG-----RTNWNRT 988

  Fly   522 SDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTS----SVTGLTAGKYYRFRIVAVYS 582
            ..|:             ::|.:||..||          :||    .|..||....|.|.:.||
  Fly   989 WVNV-------------STHVQAREVDR----------YTSRQQAEVVNLTPWSAYEFSVTAV-- 1028

  Fly   583 NNDNKEGNTSLKFFLQNGTSKSNLPVPELREVETLSESAVV----------------LHWS-LVS 630
             ||           |..||..:..|:     ..|..:...:                :.|. |:.
  Fly  1029 -ND-----------LGIGTPSAPSPI-----YSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLP 1076

  Fly   631 STQNEDIDGYYAYYR---PADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNS---DAA 689
            ..|:.....|..:::   ..:.|::.:|.....|:: ...|.|....|.||.|:|:.||   ...
  Fly  1077 QEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVA-VVNIPLNNYYTEYEVKVQAINSVGKGPE 1140

  Fly   690 SEFSAIRQARTRKTHEQPASSSATPV 715
            ||.:.|..|     .:.|..:...|:
  Fly  1141 SEIAVIHSA-----EDMPQVAPQKPI 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	26/91 (29%)
		IG_like	154..234	CDD:214653	17/90 (19%)
		Ig	172..234	CDD:299845	16/72 (22%)
		IG_like	249..329	CDD:214653	21/83 (25%)
		Ig	257..329	CDD:299845	18/72 (25%)
		IG_like	339..418	CDD:214653	23/87 (26%)
		Ig	352..408	CDD:299845	19/63 (30%)
		FN3	470..592	CDD:238020	30/125 (24%)
		FN3	613..700	CDD:238020	21/109 (19%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845
		I-set	362..462	CDD:254352
		Ig	466..559	CDD:299845
		IG_like	584..657	CDD:214653	26/96 (27%)
		IGc2	586..645	CDD:197706	21/80 (26%)
		Ig	667..751	CDD:299845	16/85 (19%)
		IG_like	676..751	CDD:214653	15/76 (20%)
		IG_like	765..844	CDD:214653	19/80 (24%)
		Ig	773..844	CDD:299845	18/72 (25%)
		I-set	851..940	CDD:254352	25/120 (21%)
		Ig	866..944	CDD:299845	23/109 (21%)
		FN3	944..1043	CDD:238020	35/165 (21%)
		FN3	1053..1146	CDD:238020	18/93 (19%)
		fn3	1156..1244	CDD:278470	1/6 (17%)
		fn3	1259..1346	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452259
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930