DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Igdcc4

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_038937673.1	Gene:	Igdcc4 / 363081	RGDID:	1310919	Length:	1345	Species:	Rattus norvegicus

Alignment Length:	1129	Identity:	229/1129 - (20%)
Similarity:	355/1129 - (31%)	Gaps:	362/1129 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNL----KPDRLEWRFRRGD--SSEP 78
            |:|.|.....:...||      ||.|       ||.:|.|..    .|..:.|. :.||  ....
  Rat   124 TVQLSCDEGPLRVVLG------PEQA-------VVLDCTLGAAAAGPPTTVTWS-KDGDVVLERD 174

  Fly    79 YLYLRPSAGYNVTS-----GSDG----LAWRLRIYVSAQTAGDYQCVAWYGP-GALASTPARLAL 133
            .|:|.|:....::|     .||.    ..|::       ..|.|.|:| :|| |.:||..|.:.|
  Rat   175 NLHLLPNGSLRLSSPLEPEDSDDEEALSVWKV-------IEGSYSCLA-HGPLGVVASQVAVVKL 231

  Fly   134 VSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRNGKKLP------------ 186
            .::.              .:|:.|::      .:|..|..|.:..:..|...|
  Rat   232 ATLE--------------DFSLHPES------QTVEENGTARFECHTEGLPAPIITWEKDQVTVT 276

  Fly   187 -QSELLPGAAGALVLDTVTAKDAGNYSCVATNSIT---GDELRLPQTIELRVDYTDRTPPYFLQR 247
             :..|:....|.|.:..|...|||:|.||||||..   ..|..|...:...::.| |.....:..
  Rat   277 EEPRLITLPNGVLQILDVQDSDAGSYRCVATNSARQRFSQEALLSVALRGSLEAT-RGQDVVIVA 340

  Fly   248 PPIEYSARPGETVVLECPGVGSPRPRVIWSSPNVVEIYNNRSTILSYGLQITDVKPEDQGSYICM 312
            .|...:...|::|||||.....|.|.|.|...:...|..:...:....|.|...:|...|.|:|.
  Rat   341 APENTTVVSGQSVVLECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIASAQPRHSGVYVCR 405

  Fly   313 L------DNGIAPPIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGE 371
            .      |...|     ..:|.||..|.|.:.|.|.....::.....|.|||.|:|.::||.:|.
  Rat   406 ANKPRTRDFATA-----AAELRVLAAPAISQAPEALSRTRASTARFVCRASGEPRPTLHWLHDGA 465

  Fly   372 DATKDPEAVVD--NRSLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEV 434
            ....:....|.  ..||.:.::..:.:|..||.|:|     |.|......||.:...:..|..
  Rat   466 PLRPNGRVKVQGGGGSLVITQIGLQDSGYYQCVAEN-----SAGTACAAAPLAVVVREGLPSA-- 523

  Fly   435 PVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQI- 498
                                                |:|...|.||..:|::.|..|:....||
  Rat   524 ------------------------------------PTRVKATPLSSSAVLVAWERPELHSEQII 552

  Fly   499 ---------------------------------------TFFKVQYRMLGDGKNRRKNWQTTSDN 524
                                                   .|:.|.|..||..:........|.|:
  Rat   553 GFSLHYQKARGVDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSSPALVHTLDD 617

  Fly   525 IPYG--NAHGSGPGQGN------------SHWRARNRDREYEMGNPPKNFTSSVTG--------- 566
            :|..  ....|.|...:            |:.:......||..|...:.|::.|.|
  Rat   618 VPSAAPQLSLSSPNPSDIRVAWLPLPSSLSNGQVVKYKIEYGSGKEDQVFSTEVPGNETQLTLNS 682

  Fly   567 LTAGKYYRFRIVAVYSNNDNKEGNTSLKF-----FLQNGT----SKSNLP-VPELREVETLSESA 621
            |...|.||.||.|          .|...:     ::|:.|    ::|::| .|...:|....||.
  Rat   683 LQPNKVYRVRISA----------GTGAGYGVPSQWMQHRTPGAHNQSHVPFAPAELKVRAKMESL 737

  Fly   622 VVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMS---------------RSFKIDLL 671
            ||........||   |.||..|:|...:..|.......||..               :.:::..|
  Rat   738 VVSWQPPPHPTQ---ISGYKLYWREVGTEEEADGDRPPGGRGDQAWDVGPVRLKKKVKQYELTQL 799

  Fly   672 RPGTPYEFKLQSFNSDAASEFSAIRQARTRK--THEQPASSSATPVPANKAVEQHQNSL------ 728
            .||..||.||.:||.. ...::|:.:.:|.|  |.:.|........||:...|.:.::.
  Rat   800 VPGRLYEVKLVAFNKH-EDGYAAVWKGKTEKAPTPDLPIQRGPPLPPAHVHAESNSSTSIWLRWK 863

  Fly   729 -----------YPLIAG--------------AAGGGILL----------------------LIAS 746
                       |.:..|              ::|..||:                      ...|
  Rat   864 KPDFTTVKIVNYTVRFGPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGS 928

  Fly   747 LVVCLCLKRRENSQPED---------------------------------ENKPQLEHIQADFVT 778
            :|....|..|.::.|.|                                 .|..|.|| |...:|
  Rat   929 VVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSNNHTQPEH-QWTLLT 992

  Fly   779 SA--VLGVGGHHKSGDVRRLNGVIPRMNITPNPLA--------QETASDKNRNVMELRFLPPLAN 833
            :.  :.....|....|.|....:..|..:.|.|.:        |||.||.    :::..:..:..
  Rat   993 TEGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQETFSDS----LDVHSVTGIIV 1053

  Fly   834 GNGNG-----NCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKL---NLP 890
            |...|     .||.  ..|.||:..|           .||.::|::.....|..:..:|   ::|
  Rat  1054 GVCLGLLCLLACMC--AGLRRSSHRE-----------ALPGLSSTATAGNPALYSRARLGPPSVP 1105

  Fly   891 QKHDQEQLDAPNAVLEAPSKPLPP 914
            ..|:.|.|..|.     |....||
  Rat  1106 AAHELESLVHPR-----PQDWSPP 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	28/104 (27%)
		IG_like	154..234	CDD:214653	23/95 (24%)
		Ig	172..234	CDD:299845	19/77 (25%)
		IG_like	249..329	CDD:214653	21/85 (25%)
		Ig	257..329	CDD:299845	20/77 (26%)
		IG_like	339..418	CDD:214653	21/80 (26%)
		Ig	352..408	CDD:299845	17/57 (30%)
		FN3	470..592	CDD:238020	34/184 (18%)
		FN3	613..700	CDD:238020	25/101 (25%)
Igdcc4	XP_038937673.1	Ig	131..223	CDD:416386	27/113 (24%)
		Ig strand A'	135..138	CDD:409353	0/2 (0%)
		Ig strand B	144..154	CDD:409353	4/9 (44%)
		Ig strand C	160..165	CDD:409353	1/5 (20%)
		Ig strand C'	167..169	CDD:409353	1/1 (100%)
		Ig strand D	175..179	CDD:409353	1/3 (33%)
		Ig strand E	182..187	CDD:409353	0/4 (0%)
		Ig strand F	209..217	CDD:409353	4/8 (50%)
		Ig_3	237..308	CDD:404760	18/76 (24%)
		Ig strand A'	243..246	CDD:409353	0/8 (0%)
		Ig strand B	252..259	CDD:409353	1/6 (17%)
		Ig strand C	265..270	CDD:409353	0/4 (0%)
		Ig strand C'	272..274	CDD:409353	0/1 (0%)
		Ig strand D	280..284	CDD:409353	1/3 (33%)
		Ig strand E	287..292	CDD:409353	2/4 (50%)
		Ig strand F	300..308	CDD:409353	5/7 (71%)
		Ig strand G	316..324	CDD:409353	2/7 (29%)
		IG_like	342..423	CDD:214653	21/85 (25%)
		Ig strand A'	342..347	CDD:409353	1/4 (25%)
		Ig strand B	353..360	CDD:409353	5/6 (83%)
		Ig strand C	366..371	CDD:409353	2/4 (50%)
		Ig strand C'	373..375	CDD:409353	0/1 (0%)
		Ig strand D	381..384	CDD:409353	0/2 (0%)
		Ig strand E	387..393	CDD:409353	2/5 (40%)
		Ig strand F	400..407	CDD:409353	3/6 (50%)
		Ig	442..514	CDD:416386	21/76 (28%)
		Ig strand B	443..451	CDD:409353	1/7 (14%)
		Ig strand C	457..462	CDD:409353	1/4 (25%)
		Ig strand C'	464..467	CDD:409353	1/2 (50%)
		Ig strand D	472..476	CDD:409353	0/3 (0%)
		Ig strand E	478..485	CDD:409353	2/6 (33%)
		Ig strand F	494..501	CDD:409353	3/6 (50%)
		Ig strand G	505..514	CDD:409353	2/8 (25%)
		fn3	522..607	CDD:394996	15/122 (12%)
		FN3	619..712	CDD:238020	19/102 (19%)
		fn3	724..818	CDD:394996	25/97 (26%)
		FN3	842..934	CDD:238020	10/91 (11%)
		FN3	942..1034	CDD:238020	14/92 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010