DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Igdcc3

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001359088.1	Gene:	Igdcc3 / 315759	RGDID:	1307338	Length:	812	Species:	Rattus norvegicus

Alignment Length:	922	Identity:	196/922 - (21%)
Similarity:	304/922 - (32%)	Gaps:	252/922 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LALVSIALDVGQGSMGARSSIRWSVAPKN-------CLLIRCGSVISNPPAIWSFYRNGKKLPQ- 187
            |.|:.:.|.|....:|..:.:.:||.|.:       .:::.| .|..:||...|:.:||.:||:
  Rat    32 LLLLLLPLPVPSLGLGHSAELAFSVEPNDDIANLGQPIMLGC-KVEGSPPVQVSWRKNGAELPED 95

  Fly   188 --SELLPGAAGALVLDTV------TAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTPPYF 244
              :.||  |.|:|::..:      :..|.|:|.|||.|       |....:..:......|...|
  Rat    96 THTTLL--ANGSLLIHHLRLEQGESPSDEGDYECVAQN-------RFGLLVSRKARIQVATMSDF 151

  Fly   245 LQRPPIEYSARPGETVVLECPGVGSPRPRVIWSSPNV-VEIYNNRSTILSYG-LQITDVKPEDQG 307
            ...|. ......|.....:|...|.|:|.:.|....| ::..:.|.|:|..| ||||.::.||.|
  Rat   152 HVHPQ-AVMGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDDERYTLLPKGVLQITGLRAEDSG 215

  Fly   308 SYICMLDNGIAPPIDHTIKLSV-------LQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIY 365
            .:.|:..|..:..:.|..:|:|       .:.||||.||...........:|:|.|:|||:|.:.
  Rat   216 VFHCVASNMASVRVSHGARLTVSGSGSGTYKEPTILVGPENLTLTVHQTAVLECVATGNPRPIVS 280

  Fly   366 W-LINGEDATKDPEAVVDNRSLQLKRVQKRHAGVVQCFAKNILG----ETSEGNILRVNPLEITG 425
            | .::|.....:...|:...:|.:..|..:|:||..| |.|..|    .|::|.::...|.|...
  Rat   281 WSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFVQ 344

  Fly   426 EDD--------------EPLGEVP---VWPVHESNTGMG----------TSSTSG---------- 453
            ...              :..||.|   .|..:....|.|          |.|.||
  Rat   345 HPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGAGGHVRLKNNNSTLSISGVGPEDEAIYQ 409

  Fly   454 -GSKNKSGRRKFKASMV---------PPSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYRML 508
             .::|.:|..:..|.:.         ||.......:|...|.:.||.|.....:|..:.:..|..
  Rat   410 CVAENIAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLTHTKEIIGYVLHIRKA 474

  Fly   509 GDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYY 573
            .|...                                   .||:.......|...|..|.....|
  Rat   475 ADSPK-----------------------------------LEYQEAVSKSTFQHLVRDLEPSTAY 504

  Fly   574 RFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNL----------PVPELREVETLSESAVVLHWSL 628
            .|.|                |.:...|.|.:::          |||....|..|..|::.|.|..
  Rat   505 SFYI----------------KAYTPRGASLASVPTLASTLGEAPVPPPLSVRLLGSSSLQLLWKP 553

  Fly   629 VSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFN----SDAA 689
            .......: .|:..:|||| |||.:....:..|...|:.:..|.|.|.||.||.::|    .:|.
  Rat   554 WPRLAQHN-GGFKLFYRPA-SAASFTGPILLPGTVSSYNLSQLDPSTVYEVKLLAYNQNGDGNAT 616

  Fly   690 SEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSLYPLIAGAAGGGILLLIASLV------ 748
            ..|.:::.|..|       ::...|....|....:..|...::.|...|...::...|.
  Rat   617 VRFVSLKGASER-------TALTPPCDCRKEEVTNHTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 674

  Fly   749 --VCLCLKRRENSQPEDENKPQLEHIQADFVTSAVLGVGGHHKSGDVRRLNGVIPRMNITPNPLA 811
              |.|| |..||..    :.||....|.|               ..:..||||
  Rat   675 GRVLLC-KDVENQL----SPPQGPRSQRD---------------PGILTLNGV------------ 707

  Fly   812 QETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCE 876
                   ||               |.|..:.||          ::..|..|.|:..|..||:...
  Rat   708 -------NR---------------GEGGQLGRD----------EKHVDAKELEQLFPTTASAGQP 740

  Fly   877 TLEACDAAIKLNLPQKHDQEQLD---------APNAVLEAPSKPLPPLPKKPANGAGQNNSGLHQ 932
            ...:.|.    ..|..:::.||.         |.....|..|....|.|...:...|.......|
  Rat   741 GSRSTDP----TAPTPYEETQLSMVQLQDFNLAAGRTTETMSSCAGPGPVPASQDVGLGLLSDRQ 801

  Fly   933 NGLHHAQPYHPP 944
            .    |||...|
  Rat   802 T----AQPLAVP 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	196/922 (21%)
		IG_like	154..234	CDD:214653	25/95 (26%)
		Ig	172..234	CDD:299845	20/70 (29%)
		IG_like	249..329	CDD:214653	22/81 (27%)
		Ig	257..329	CDD:299845	22/73 (30%)
		IG_like	339..418	CDD:214653	22/83 (27%)
		Ig	352..408	CDD:299845	18/56 (32%)
		FN3	470..592	CDD:238020	18/121 (15%)
		FN3	613..700	CDD:238020	26/90 (29%)
Igdcc3	NP_001359088.1	Ig	54..145	CDD:386229	25/100 (25%)
		Ig	153..237	CDD:386229	23/84 (27%)
		IG_like	254..336	CDD:214653	22/82 (27%)
		I-set	341..427	CDD:369462	14/85 (16%)
		FN3	434..527	CDD:238020	21/143 (15%)
		fn3	<554..613	CDD:365830	18/60 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010