DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and sdk

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	184/934 - (19%)
Similarity:	299/934 - (32%)	Gaps:	294/934 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QASDSNSSVATTLGV----LFERAPESAVAPK------GDEVV-FECELNLKP-DRLEWRFRRGD 74
            |.....||....|.|    ..|.|||..|.|:      |..|| .:|..|.:| ..||
  Fly   237 QLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELE------- 294

  Fly    75 SSEPYLYLRPSAGYNVTSGSDGLA-------------WR---LRIYVSAQTAGDYQCVAWYGPGA 123
                .|:|:           ||||             |.   ..:..::..:|:|.|......|.
  Fly   295 ----TLWLK-----------DGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGG 344

  Fly   124 --LASTPARLALVSIALDVGQ------GSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYR 180
              ..|..|||.::...|....      |..|.:            :.:.| .|:..|.....::|
  Fly   345 YPAVSASARLQILEPPLFFTPMRAETFGEFGGQ------------VQLTC-DVVGEPTPQVKWFR 396

  Fly   181 NGKK----LPQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGD------------------- 222
            |.:.    :............||:..:...||..:.|:|.|. .|:
  Fly   397 NAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINE-AGENSASTWLRVKTKTAKNRVK 460

  Fly   223 ELRLPQTIELRVDY-------------TDRTPPY------FLQRPPIEYSARPGETVVLECPGVG 268
            .|..|:.:.:|..:             :||...:      .::.||...:|..|:...:.|..||
  Fly   461 RLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVG 525

  Fly   269 SPRPRVIW--SSPNVVEIYNNRSTILSYG-LQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVL 330
            ||.|.:.|  :...:|:| ::|..||..| |.|::::..|.|.|||:..|. |..:.....||||
  Fly   526 SPNPNITWIYNETQLVDI-SSRVQILESGDLLISNIRSVDAGLYICVRANE-AGSVKGEAYLSVL 588

  Fly   331 QRPTILRGPAATLTNESNPLLLDCSASGNPQP--DIYWLINGEDATKDPEA----VVDNRSLQLK 389
            .|..|::.|..|.........|.|..|.:|..  :|.|...|:.:|....:    |..:..|:::
  Fly   589 VRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQ 653

  Fly   390 RVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSGG 454
            .|:....|...|..                                              ::.||
  Fly   654 AVRASDVGSYACVV----------------------------------------------TSPGG 672

  Fly   455 SKNKSGRRKFKASMVPPSRPNVTRLSD---ESVMLRWSVPQNSGLQITFFKVQYR---MLGDGKN 513
            ::.::.|........|||...|.||.:   .|:.:.|:...:....|:.|.:|.|   .||...:
  Fly   673 NETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPD 737

  Fly   514 RRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIV 578
            ...||.|...|:           ..:..|                   ..:..|.|...|:||:.
  Fly   738 PLLNWITELSNV-----------SADQRW-------------------ILLENLKAATVYQFRVS 772

  Fly   579 AVYSNNDNKEGNTSLKFFLQNGTSKSNL-----------PVPELREVETLSESAVVLHWS-LVSS 631
            ||   |...||:.|         ..||:           ||..:....::||  ::..|. .:..
  Fly   773 AV---NRVGEGSPS---------EPSNVVELPQEAPSGPPVGFVGSARSMSE--IITQWQPPLEE 823

  Fly   632 TQNEDIDGYYAYYRP-ADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAI 695
            .:|..|.||...||. ..:...:....:.....|:|.|..|.....|..::.::|:.....::..
  Fly   824 HRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEG 888

  Fly   696 RQARTRK-THEQPASSSATPVPANKAVEQHQNSLYPLIAGAAGGGILLLIASLVVCLCLKRRENS 759
            .:.:|:: ..|.|        |.|..||...::                     ...|.....|.
  Fly   889 SKIKTKEGVPEAP--------PTNVKVEAINST---------------------AARCRWTPPNP 924

  Fly   760 QPEDENKPQLEHIQADFVTSAVLG--VGGHHKSGDVRRLNGVIPRMNITP----NPLAQETA--- 815
            |       |:..|...:...|...  :.|..:  |:.|      ||...|    :|||::||
  Fly   925 Q-------QINGINQGYKIQAWQRRLIDGEWR--DIER------RMKTVPPSLIDPLAEQTAILG 974

  Fly   816 ---SDKNRNVMELRFLPPLANGNG 836
               .....|:..|.|..|   |:|
  Fly   975 GLEKFTEYNISVLCFTDP---GDG 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	25/114 (22%)
		IG_like	154..234	CDD:214653	15/102 (15%)
		Ig	172..234	CDD:299845	13/84 (15%)
		IG_like	249..329	CDD:214653	26/82 (32%)
		Ig	257..329	CDD:299845	24/74 (32%)
		IG_like	339..418	CDD:214653	15/84 (18%)
		Ig	352..408	CDD:299845	13/61 (21%)
		FN3	470..592	CDD:238020	29/127 (23%)
		FN3	613..700	CDD:238020	15/88 (17%)
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845	2/7 (29%)
		IG_like	280..356	CDD:214653	20/97 (21%)
		Ig	280..343	CDD:299845	15/84 (18%)
		IG_like	375..450	CDD:214653	14/88 (16%)
		Ig	378..447	CDD:143165	13/70 (19%)
		Ig	506..587	CDD:299845	26/82 (32%)
		IG_like	506..587	CDD:214653	26/82 (32%)
		I-set	592..682	CDD:254352	19/135 (14%)
		Ig	595..682	CDD:299845	18/132 (14%)
		FN3	686..789	CDD:238020	32/144 (22%)
		FN3	798..893	CDD:238020	17/96 (18%)
		FN3	901..1005	CDD:238020	28/142 (20%)
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010