DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and cdon

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001075097.1	Gene:	cdon / 280652	ZFINID:	ZDB-GENE-021115-4	Length:	1125	Species:	Danio rerio

Alignment Length:	1235	Identity:	287/1235 - (23%)
Similarity:	439/1235 - (35%)	Gaps:	366/1235 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IRLVVVLLVLMTTCIYTLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEW 68
            :||:..:|.:..|.:.         :..|.|...|...|.||:..:|..|...|..:....|:.|
Zfish     6 LRLLSAVLCVCHTLLL---------NCPTVLSFSFRAEPLSAILKQGSSVHLHCTTHPATARISW 61

  Fly    69 RFRRGDSSEPYLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTA--GDYQCVAWYGPGALASTPARL 131
            .|:    .:|   |.||....|....|.|:     ..:.|.|  |.|||.|....|::.|..||
Zfish    62 LFQ----GQP---LDPSHHSGVELSQDSLS-----LSNLQPALTGSYQCSARSETGSIISRHAR- 113

  Fly   132 ALVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRNGKKLPQSE----LLP 192
              |:|| |:.:.:...|.|  ::|...:..:|.|....|||||:..|...||.|.||.    :||
Zfish   114 --VTIA-DIEEFAETHRRS--FTVNKGDTAVIECPLPRSNPPALPRFRIRGKWLEQSTDEYLILP 173

  Fly   193 GAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTPPYFLQRP--PIEYSAR 255
              :|.|.:.:|:::..|.|.|.|.|.:|.:........:|.|..::.:.|..:..|  |...:..
Zfish   174 --SGNLQIVSVSSEHQGMYKCGAYNPLTRETRVEAHGTKLLVKDSESSSPVRIVYPITPRSLTVD 236

  Fly   256 PGETVVLECPGVGSPRPRVIWSSPNVVEIYNNRSTILSY-GLQITDVKPEDQGSYICML--DNGI 317
            ...::.|||...||...:|.|.. |..|:..:...:||: .|.:.|::|.|.|.|.|.:  |.|.
Zfish   237 QSGSLTLECVVSGSLSSKVKWMK-NGAELSLSSKRMLSHSNLVLNDIQPGDGGHYSCSVPTDRGA 300

  Fly   318 APPIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDATKDPEAVVD 382
            ...:::|:  :||...:||||.:.......:.:...|:|||||.|:|.||:|....:..|...:.
Zfish   301 VVSVNYTV--NVLAHVSILRGLSDQAAVAGSSVRFTCAASGNPTPNITWLLNAAPLSSSPRLKIS 363

  Fly   383 NRSLQLKRVQKRHAGVVQC-FAKNILGETSEGNIL-------------------RVNPLEITGED 427
            ..||.:.....:..|:.|| |...|....|.|.:.                   .|:|::....|
Zfish   364 GTSLLISSTTLQDQGIYQCMFDNGISSAQSTGRLSIQSEPQSSSISAVPVKTQPSVHPIQSDEGD 428

  Fly   428 -----------------------DEPLGEVPV--------------------------------- 436
                                   |.|..|.|:
Zfish   429 ELFLSMGEAALGETVGPPTERIGDRPTPEAPIIISPPQTHKPNMYDLEWRAGRDWGIAIIAYFVK 493

  Fly   437 -------------W------------PVHE--------------SNTGMGTSS----TSGGSKNK 458
                         |            |:.|              |..|.|..:    .:|..:..
Zfish   494 YRKVDDMGNVVGSWHTVRVPGSEKSLPLSELEPSSLYEVLMVARSAAGEGQPAMLTFRTGKERAS 558

  Fly   459 SGRRKFKASMV--------------------------PPSRPNVTRLSDESVMLRWSVPQNSGLQ 497
            ..:...||.:|                          .|.||.::..::.||.:.|....|.|..
Zfish   559 PNKNPSKAPIVSLPEKTPEDKTTNTYYGVVIHDRVPEAPDRPTISMATESSVYVTWIPRANGGSP 623

  Fly   498 ITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTS 562
            ||.|:|:||..|    |..:|...:|||                              .|...:.
Zfish   624 ITAFRVEYRKQG----RNGDWIIAADNI------------------------------SPLKLSV 654

  Fly   563 SVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSK-SNLPV--PELREVETLSESAVVL 624
            .|..|..|..||||::|:.:..::....||..:.:...:|. ||.||  |.:...:.:|::.::|
Zfish   655 EVRNLEPGSTYRFRVIAMNNYGESPASATSRPYQVSMSSSPVSNRPVTGPHISSTDAVSDTQILL 719

  Fly   625 HWSLV-SSTQNEDIDGYYAYYRPADS--AAEYLKATVDGGMSRSFK----IDLLRPGTPYEFKLQ 682
            .|:.. ||..|..|.|:|.||||.||  .::|.|..|:|     ||    |..|:|.|.|:.|:|
Zfish   720 RWTYTPSSNNNTPIQGFYIYYRPTDSDNDSDYKKDVVEG-----FKFWHMIGELQPETSYDIKMQ 779

  Fly   683 SFNSDAASEFSAIRQARTRKTHEQPASSSATPV------PANKAVEQHQNSLYPLIAGAAGGGIL 741
            .:|....||:|.:....| |..:.|...|..|:      ||: ...|....||.::....|..:|
Zfish   780 CYNDGGESEYSNVMICET-KARQPPGVPSLRPITPPGFYPAD-TPSQPGGLLYLIVGCVLGVMVL 842

  Fly   742 LLIASLVVCLCLKRRENS-----------QPEDENKPQLEHIQADFVTSAVLGVGGHHKSGDVRR 795
            :|:..:|:||...|::||           |..:.|...|::       ||:  .|..|.:|.|..
Zfish   843 ILLVFIVMCLWRNRQQNSMHKYDPPNYIYQSAEMNGHVLDY-------SAL--PGSSHVNGSVHT 898

  Fly   796 LNG-VIPRMNIT--------PNPLAQETASDKNRNVMELRFLPPLANGNGN----GNCMARDLAL 847
            ..| ..|.|..|        ||.||                   |.||:|.    |:..|.|.:|
Zfish   899 GCGHTAPMMPQTCHHLHHKLPNGLA-------------------LLNGSGGLYPAGHPHAHDTSL 944

  Fly   848 ERSNAEEQQDEDGHEDEKG-----LPAVASSSCETLEACDAAIKLNLPQKHDQEQLDAPNAVLEA 907
            .::|.|.:.....|....|     ||...||.|.:.:
Zfish   945 HQNNMEYEHPSPHHLHNGGGIYTALPQNDSSDCMSCQ---------------------------- 981

  Fly   908 PSKPLPPLPKKPANGAGQNNSGLHQNGLHHAQPYHPPGTPTLMHKRLDYHQQPP-----PVPP-- 965
                         |....|......||....      ||..|||:..  .:||.     |:.|
Zfish   982 -------------NFCNNNRCYTKTNGTFSG------GTLPLMHRVA--ARQPDGLEMMPLNPIL 1025

  Fly   966 ---HSAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHS 1027
               |.....|....|....::::..|:..|.. |.....|..|: .||.:||   |.|||.:..|
Zfish  1026 SRCHGRDSPQLNGCQDRDSVQQAEEGNVPPLS-HNSPCLPVETK-SSLEQQR---GVQQVQHEDS 1085

Fly 1028 1027
Zfish 1086 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	26/90 (29%)
		IG_like	154..234	CDD:214653	26/83 (31%)
		Ig	172..234	CDD:299845	21/65 (32%)
		IG_like	249..329	CDD:214653	22/82 (27%)
		Ig	257..329	CDD:299845	21/74 (28%)
		IG_like	339..418	CDD:214653	21/98 (21%)
		Ig	352..408	CDD:299845	19/56 (34%)
		FN3	470..592	CDD:238020	29/121 (24%)
		FN3	613..700	CDD:238020	32/93 (34%)
cdon	NP_001075097.1	Ig	30..116	CDD:299845	29/100 (29%)
		IG_like	35..116	CDD:214653	28/95 (29%)
		IG_like	131..213	CDD:214653	26/83 (31%)
		Ig	139..196	CDD:299845	22/58 (38%)
		IG_like	230..310	CDD:214653	22/82 (27%)
		IGc2	239..294	CDD:197706	18/55 (33%)
		I-set	315..399	CDD:254352	25/83 (30%)
		Ig	317..399	CDD:299845	24/81 (30%)
		FN3	456..552	CDD:238020	8/95 (8%)
		FN3	594..685	CDD:238020	30/124 (24%)
		FN3	700..797	CDD:238020	35/101 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102649at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26502
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10179
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950