DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Dcc

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_031857.2	Gene:	Dcc / 13176	MGIID:	94869	Length:	1447	Species:	Mus musculus

Alignment Length:	1301	Identity:	261/1301 - (20%)
Similarity:	412/1301 - (31%)	Gaps:	471/1301 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FERAPESAVAPKGDEVVFECELNLKPDR----LEWRFRRGDSSEPYLYLRPSAGYNVTSGSDGLA 98
            |...|..||..:|..|:..|  :.:.||    ::|:               ..|..:..|.|...
Mouse    42 FVSEPSDAVTMRGGNVLLNC--SAESDRGVPVIKWK---------------KDGLILALGMDDRK 89

  Fly    99 WRL--------RIYVSAQTAGD---YQCVAWYGPGALA---STPARLALVSIALDVGQGSMGARS 149
            .:|        .|..|.....|   |||.|     :||   |..:|.|.|::|     |.:...|
Mouse    90 QQLPNGSLLIQNILHSRHHKPDEGLYQCEA-----SLADSGSIISRTAKVTVA-----GPLRFLS 144

  Fly   150 SIRWSVA-PKNCLLIRCGSVISNPPAIWSFYRNGKKLPQSEL--LPG-------AAGALVLDTVT 204
            ......| ..:.:|::| .||..|.....:.:|     |.:|  |||       .:|||.:..:.
Mouse   145 QTESITAFMGDTVLLKC-EVIGEPMPTIHWQKN-----QQDLNPLPGDSRVVVLPSGALQISRLQ 203

  Fly   205 AKDAGNYSCVATN--SI-TGDELRLPQTIELRV--DYTDRTPPYFLQRPPIEYSARPGETVVLEC 264
            ..|:|.|.|.|.|  || ||:|      .|:|:  |.......||||||. ...|..|:..||||
Mouse   204 PGDSGVYRCSARNPASIRTGNE------AEVRILSDPGLHRQLYFLQRPS-NVIAIEGKDAVLEC 261

  Fly   265 PGVGSPRPRVIW-SSPNVVEIYNNRSTIL-SYGLQITDVKPEDQGSYICML----DNGIAPPIDH 323
            ...|.|.|...| ....|:::.:.:.::| ...|.|::|..:|.|:|.|::    :|     |..
Mouse   262 CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNEN-----ISA 321

  Fly   324 TIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDA-TKDPEAVVDNRSLQ 387
            :.:|:||..|..|..|:.....||..:..:|:.||.|.|.:.|:.||:.. ..|...:|...:|:
Mouse   322 SAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLR 386

  Fly   388 LKRVQKRHAGVVQCFAKNILGET------------------------------------------ 410
            :..|.|...|..||.|:|..|..
Mouse   387 ILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRP 451

  Fly   411 ---SEGNI--------------------LRVNPLEIT----------------------GEDDEP 430
               ::|||                    .:...|::|                      ||..:|
Mouse   452 PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQP 516

  Fly   431 LG-------EVPVWPVHESNTGMGTSSTS------------------------------------ 452
            :.       :|| .|| |:...:.||.||
Mouse   517 IKVATQPELQVP-GPV-ENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVD 579

  Fly   453 GGSKNKSGRRKF----------------------------KASMVPPSRPNVTRLSDESVMLRWS 489
            |.|....|.:||                            .....||...::..::..|:.:.|
Mouse   580 GLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSW- 643

  Fly   490 VPQNSGLQ---ITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREY 551
            :|..||.|   ||.:|:::|     |..|:....|.:
Mouse   644 LPPPSGTQNGFITGYKIRHR-----KTTRRGEMETLE---------------------------- 675

  Fly   552 EMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNLP-VPELREVE 615
                 |.|.....|||..|..|.|::.|:..|......|.......:|...:|.:| .|....|.
Mouse   676 -----PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR 735

  Fly   616 TLSESAVVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFK 680
            . ..:.:::.|: .....|..:.||...|......||.::  || ...|.:.|:.|...:.|...
Mouse   736 P-QTNCIIMSWT-PPLNPNIVVRGYIIGYGVGSPYAETVR--VD-SKQRYYSIERLESSSHYVIS 795

  Fly   681 LQSFNSDAASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSLYPLIAGAAGGG------ 739
            |::||:  |.|...:.::.|.::...|..    ||           ..|||:......|
Mouse   796 LKAFNN--AGEGVPLYESATTRSITDPTD----PV-----------DYYPLLDDFPTSGPDVSTP 843

  Fly   740 ILLLIASLVVCLC-----LKRRENSQPEDENKPQLEHIQADFVTSAVLGVGGHHKSGDVRRLN-- 797
            :|..:....|.|.     :...:||.|:::....:......:.||  ......:||.|...|:
Mouse   844 MLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTS--FSASAKYKSEDTTSLSYT 906

  Fly   798 --GVIP-------------RMNIT-----------------PNPLAQETASDKNRNVMELRFLPP 830
              |:.|             |.:.|                 |..|...|...|.|.|: :.:.||
Mouse   907 ATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVI-VSWQPP 970

  Fly   831 L-ANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEA---CDAAIKLNLPQ 891
            | |||......:...|                  :|.:| :.....||:..   ....:.|:|..
Mouse   971 LEANGKITAYILFYTL------------------DKNIP-IDDWIMETISGDRLTHQIMDLSLDT 1016

  Fly   892 KHDQEQLDAPNAVLEAPSKPLPPL-------------PKKPANGAGQNNSGLHQNGLHHAQPYHP 943
            .: ..::.|.|.      |.:.||             |.|.||..|::..|          .|.|
Mouse  1017 MY-YFRIQARNV------KGVGPLSDPILFRTLKVEHPDKMANDQGRHGDG----------GYWP 1064

  Fly   944 PGTPTLMHKRLDYHQQPPPVPPHSAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPTR-- 1006
            ..|..:....|:    .||:                             |..|...|:.||.:
Mouse  1065 VDTNLIDRSTLN----EPPI-----------------------------GQMHPPHGSVTPQKNS 1096

  Fly  1007 -------------------IPSLRRQRRTSGNQQVHN-SHSNLNIGLSHHNNNNNNLPPHHQHLH 1051
                               |.::...||:|..|:... :||     :|....:..:|.|....:|
Mouse  1097 NLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHS-----VSKRKGSQKDLRPPDLWIH 1156

  Fly  1052 H 1052
            |
Mouse  1157 H 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	23/106 (22%)
		IG_like	154..234	CDD:214653	27/92 (29%)
		Ig	172..234	CDD:299845	22/73 (30%)
		IG_like	249..329	CDD:214653	22/85 (26%)
		Ig	257..329	CDD:299845	21/77 (27%)
		IG_like	339..418	CDD:214653	25/144 (17%)
		Ig	352..408	CDD:299845	18/56 (32%)
		FN3	470..592	CDD:238020	26/124 (21%)
		FN3	613..700	CDD:238020	19/86 (22%)
Dcc	NP_031857.2	Ig1_Neogenin	42..136	CDD:143199	27/115 (23%)
		IG_like	46..136	CDD:214653	26/111 (23%)
		IG_like	147..224	CDD:214653	24/82 (29%)
		IGc2	153..219	CDD:197706	20/71 (28%)
		I-set	241..327	CDD:254352	28/91 (31%)
		Ig	244..327	CDD:299845	25/88 (28%)
		I-set	331..417	CDD:254352	24/85 (28%)
		Ig	347..417	CDD:299845	19/69 (28%)
		FN3	429..521	CDD:238020	8/91 (9%)
		FN3	528..617	CDD:238020	13/90 (14%)
		FN3	625..715	CDD:238020	26/128 (20%)
		FN3	726..805	CDD:214495	20/85 (24%)
		FN3	846..939	CDD:238020	15/94 (16%)
		FN3	946..1041	CDD:238020	24/121 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1153		7/31 (23%)
		Neogenin_C	1148..1445	CDD:284094	4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1220
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1291..1329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010