DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and Boc

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_766094.1	Gene:	Boc / 117606	MGIID:	2151153	Length:	1110	Species:	Mus musculus

Alignment Length:	1274	Identity:	288/1274 - (22%)
Similarity:	433/1274 - (33%)	Gaps:	448/1274 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVVVLLVLMTT--CIYTLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEW 68
            ::.:|.:||.|  |:     :|.|.....|:      .|.|.|...|..|:..|.:......:.|
Mouse    10 ILTLLWILMATAGCL-----ADLNEVPQVTV------QPMSTVQKLGGTVILGCVVEPPWMNVTW 63

  Fly    69 RF--RRGDSSEPYLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGALASTPARL 131
            ||  :..:.|:..|      |..:|.|:..:|     .::..|.|.|||||....||:||.||.:
Mouse    64 RFNGKELNGSDDAL------GVFITRGTLVIA-----ALNNHTVGRYQCVARMPAGAVASVPATV 117

  Fly   132 ALVSI---------ALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPA--IWSFYRNGKKL 185
            .|.::         .::|.:|               |..:|.|....|:|.|  .:|..:...:.
Mouse   118 TLANLQDFKLDVQHVIEVDEG---------------NTAVIACHLPESHPKAQVRYSVKQEWLEA 167

  Fly   186 PQSELLPGAAGALVLDTVTAKDAGNYSCVATNSIT--------GDELRLPQ-TIE-LRVDYTDRT 240
            .:...|...:|.|.:...:.:|.|.|.|.|.|.:|        ||.||:.: |.| .|:.|
Mouse   168 SRDNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSGDRLRVRRSTAEAARIIY---- 228

  Fly   241 PPYFLQRPPIEYS---ARPGETVVLECPGVGSPRPRVIWSSP-NVVEIYNNRSTILSYGLQITDV 301
                    |:|..   ...|::::|||...|.|.|||.|:.. :.:..||....:|| .|.|...
Mouse   229 --------PLEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYNKTRFLLS-NLLIDTT 284

  Fly   302 KPEDQGSYICMLDNGIA---------------PPIDHTIKLSVLQRPTILRGPAATLTNESNPLL 351
            ..||.|:|.||..||:.               || :.|::||.|..|.   |.:|.||
Mouse   285 SEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPP-EVTVELSQLVIPW---GQSAKLT------- 338

  Fly   352 LDCSASGNPQPDIYWLINGEDATKDPEAVVDNRSLQLKRVQKRHAGVVQCFAKNILGE------- 409
              |...|||.|.:.||.|....|......:..|:|::..|.....||.||.|:|.:|.
Mouse   339 --CEVRGNPPPSVLWLRNAVPLTSSQRLRLSRRALRVVSVGPEDEGVYQCMAENAVGSAHAVVQL 401

  Fly   410 -----------------------------TSEGNILRVNP--------------LEITGEDDEPL 431
                                         :....:||..|              |:..||:....
Mouse   402 RTARPDTTLRPGRDTKPIAATPPMPPSRPSRPDQMLREQPGLVKPPTSSVQPTSLKCPGEEQVAP 466

  Fly   432 GEVP----------------VW-PVHESNTGMGTSST---------------------SGGSKN- 457
            .|.|                || |.||     |:|.|                     ||...|
Mouse   467 AEAPIILSSPRTSKTDSYELVWRPRHE-----GSSRTPILYYVVKHRKVTNSSDDWTISGIPANQ 526

  Fly   458 ----------------------------------KSGRR--------------------KFKASM 468
                                              ::|||                    ..::|.
Mouse   527 HRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDDPGASLQSSS 591

  Fly   469 VP----------PSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYRML---GDGKNRRKNWQT 520
            .|          |.||.::..|:.||.:.|....|.|..|..|:|:|:.|   ||       |..
Mouse   592 QPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGD-------WIL 649

  Fly   521 TSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNND 585
            .:..|                              ||...:..:|||..|..|:||:.|:....:
Mouse   650 ATSAI------------------------------PPSRLSVEITGLEKGISYKFRVRALNMLGE 684

  Fly   586 NKEGNTSLKFFLQNGTSK-SNLPV--PELREVETLSESAVVLHWSLV-SSTQNEDIDGYYAYYRP 646
            ::....|..:.:...:.: ...||  |.:...:.::|:.::|.|..: :|..|..|.|:|.||||
Mouse   685 SEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRP 749

  Fly   647 ADS--AAEYLKATVDGGMSRSF-KIDLLRPGTPYEFKLQSFNSDAASEFS--AIRQARTRKTHEQ 706
            .||  .::|.|..|:|  .|.: .|..|:|.|.|:.|:|.||....||||  .|.:.:.||...|
Mouse   750 TDSDNDSDYKKDMVEG--DRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKFSGQ 812

  Fly   707 PAS----SSATPVP----------ANKAVEQHQNSLYPLIAGAAGGGILLLIASLVVCLCLKRRE 757
            |..    :.|.|.|          ...|:....:.|..||.|...|.|:|:|.:.:. .||.|..
Mouse   813 PGRPPPLTLAPPQPPPLETMERPVGTGAMVARASDLPYLIVGVVLGSIVLIIVTFIP-FCLWRAW 876

  Fly   758 NSQPEDENKPQLEHIQADFVTSAVL------------GVGGHHKSGD-----------VRRLNGV 799
            :.|....:        ..|..||:|            |:.||..:|.           |.|::|.
Mouse   877 SKQKHTTD--------LGFPRSALLSSSCQYTMVPLEGLPGHQANGQPYLGGVSGRACVSRVHGS 933

  Fly   800 --IPRMNI----------TPNPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERSNA 852
              .|...:          .|..|||: ..|.|..:.:    |.::||        .||
Mouse   934 RGCPAATVGCPGRKPQQHCPGELAQQ-REDTNSQLRQ----PIVSNG--------YDL------- 978

  Fly   853 EEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLPQK--HDQEQ-----LDAPNAVLEAP-- 908
            :.||...|.:...|:.|...:..:     |:..:|..||.  |.|:|     ..|.....|:|
Mouse   979 QNQQVARGPQCASGVGAFLYTLPD-----DSTHQLLQPQDCCHLQKQPVTTCQTAVRRTSESPGL 1038

  Fly   909 -SKPLPPLPKKPANGAG------QNNSGLHQNGLHHAQPYHPPGTPTLMHKRLDYHQQPPPVPPH 966
             |...||....|....|      .::|...|.|.......||.||.|...:.:.:
Mouse  1039 ESSWDPPYHSGPQCCLGLVPVEEVDSSDSCQVGGGDWSSQHPSGTYTGQERGMRF---------- 1093

  Fly   967 SAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPT 1005
                      .|||.:             |:...||.||
Mouse  1094 ----------SPSPSV-------------HVSFETPPPT 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	28/90 (31%)
		IG_like	154..234	CDD:214653	23/91 (25%)
		Ig	172..234	CDD:299845	19/73 (26%)
		IG_like	249..329	CDD:214653	30/98 (31%)
		Ig	257..329	CDD:299845	28/87 (32%)
		IG_like	339..418	CDD:214653	23/114 (20%)
		Ig	352..408	CDD:299845	18/55 (33%)
		FN3	470..592	CDD:238020	29/134 (22%)
		FN3	613..700	CDD:238020	33/92 (36%)
Boc	NP_766094.1	I-set	31..120	CDD:254352	29/105 (28%)
		Ig	35..118	CDD:299845	28/99 (28%)
		IG_like	132..207	CDD:214653	19/89 (21%)
		Ig	138..199	CDD:299845	16/75 (21%)
		Ig	243..301	CDD:299845	23/58 (40%)
		I-set	318..401	CDD:254352	29/95 (31%)
		IGc2	332..393	CDD:197706	22/69 (32%)
		ISET-FN3_linker	404..468	CDD:293231	6/63 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..458		4/50 (8%)
		FN3	481..553	CDD:214495	11/76 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..610		8/48 (17%)
		FN3	601..692	CDD:238020	28/127 (22%)
		FN3	707..804	CDD:238020	36/98 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..828		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1110		16/78 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3668
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102649at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970