DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boi and neo1

DIOPT Version :9

Sequence 1:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_012821597.1	Gene:	neo1 / 100170189	XenbaseID:	XB-GENE-922578	Length:	1451	Species:	Xenopus tropicalis

Alignment Length:	1359	Identity:	285/1359 - (20%)
Similarity:	441/1359 - (32%)	Gaps:	434/1359 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKP-DRLEWRFRRGD----SSEPY 79
            |..|..:.|...|.....|...|...|..:|...|..|.....| .::||: :.|.    .|:..
Frog    31 TWAAKTAGSGFRTFTPFYFLTEPVDTVTLRGFAAVLNCSAYADPTPKIEWK-KDGTFLNLVSDDR 94

  Fly    80 LYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGD---YQCVAWY-GPGALASTPARLALVSIALDV 140
            ..|.|.....:||          :..|.....|   |||||.. ..|::.|..|||::..:.
Frog    95 RRLLPDGSLLITS----------VVHSKHNKPDEGIYQCVATVESLGSIVSRTARLSVAGLP--- 146

  Fly   141 GQGSMGARSSIRWSVAPKNCLLIRCGSVISN--------PPAIWSFYRNGKKLPQ--SELLPGAA 195
                       |::..|::..:....|::.|        |...|...:..::|..  :.||   .
Frog   147 -----------RFTSQPESSSVYVGDSIVLNCDVSPELVPFVHWEQNKASRELDNRVAVLL---N 197

  Fly   196 GALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRV--DYTDRTPPYFLQRPPIEYSARPGE 258
            |:||:......|||.|.|....   |..::..:..|:||  |..|..|..|| |.|:..:...|:
Frog   198 GSLVISNANESDAGLYRCAVGG---GSSIKYSEEAEIRVLQDTGDERPMLFL-RQPLPLTRVSGQ 258

  Fly   259 TVVLECPGVGSPRPRVIWSSPNVVEIYNNRSTILSY----GLQITDVKPEDQGSYICMLDNGIAP 319
            |.:|.|...|.|.|.|.|:. |..||....|..|::    .|||:.|..||.|.|.|:.|||
Frog   259 TALLTCVVSGYPTPSVRWTH-NQKEILTENSETLTFVAGGSLQISSVTEEDSGIYTCIADNG--- 319

  Fly   320 PIDHTI----KLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDA-TKDPEA 379
              :.||    :||:...|.....|:.|..:||..::..|..:|.|.|.:.|:.||:.. ..|...
Frog   320 --NQTIQAHAELSIQVPPIFHVKPSNTHAHESMDIVFKCEVTGKPTPTVKWVKNGDMVIPSDYFK 382

  Fly   380 VVDNRSLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWPVHESN- 443
            :|::..||:..:.:...|..||.|:|     ..||:.....|.|.    ||...:|..|.....
Frog   383 IVEDHDLQVLGLVRSDEGFYQCIAEN-----EVGNVQAAAQLIIL----EPGVTIPTSPTPSLTR 438

  Fly   444 -TGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYRM 507
             |....::|.||.. .|..|...||:|          |...:.|.|.:|.:...:...::|.|..
Frog   439 ATAHNVAATPGGPL-PSSPRDVVASLV----------STRFIKLTWRMPADPHGENLTYQVYYSK 492

  Fly   508 LGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKY 572
              :..||.                           |..|..|..||       ..::..|.....
Frog   493 --ESMNRE---------------------------RVENTSRPGEM-------QVTIQNLLPETV 521

  Fly   573 YRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNLPV-----PELR--------EVETLSESAVVL 624
            |.||:||     .|           |||..:|:||:     ||::        :...:|.::|.:
Frog   522 YYFRVVA-----QN-----------QNGAGESSLPLKVETQPEVQVPGPAPNFKATPVSPTSVSV 570

  Fly   625 HWSLVSSTQNEDIDGYYAYY--RPADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSD 687
            .|....| .|.:|..|..||  :.||:..:     ||.| ..|:.::.|:..|.|.|::.:||..
Frog   571 SWETPLS-GNGEIQSYKLYYMEKGADNEQD-----VDVG-GHSYTLNGLKKYTEYTFRVVAFNKH 628

  Fly   688 AASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSL---YPLIAGAAGGGILLLIASLVV 749
            ...  .:.:....|...:.|   ||.|......|...|:.|   .|...|:..|.|        |
Frog   629 GPG--VSTQDVTVRTLSDVP---SAAPQNLTLEVRSSQSILVQWQPPPIGSQNGQI--------V 680

  Fly   750 CLCLKRRENSQPEDENKPQLEHIQADFVTSAV------------LGVGGHHKSG----------- 791
            ...::.|:.:: :.|....|...|..::.:|:            |.|.|   ||
Frog   681 GYKVRYRKTTR-KSETSEILVDAQLSYLFTALERDTEYSFRAVALTVNG---SGPASDWVSAETF 741

  Fly   792 ----DVRRLNGVIPRMNITP---NPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLAL-- 847
                |..|:..|...:::.|   |.:...|..:....|:...:    |.|.|.|:..|:.:.:
Frog   742 ESDLDESRVPDVPSSLHVRPLVTNIVVSWTPPENQHQVVVRGY----AIGYGLGSPHAQTVRVDH 802

  Fly   848 -ERSNAEEQQDEDGH---------EDEKGLPAVASSSCETLEACDAAIKLNLPQKHDQEQLDAPN 902
             :|....:..:...|         ...:|:|..  .|..|.:..|       |...|...:.||.
Frog   803 KQRYYTIDNLEPSSHYVISLRAFNNVGEGIPLY--ESAVTRQHTD-------PSDVDVFVVHAPY 858

  Fly   903 AVLEAPSKPLPP---------------------LPKK-----------------PANG----AGQ 925
            ..:..||..|||                     |||.                 |||.    |..
Frog   859 TPVPEPSPMLPPVGVQATIVASDTVRLTWADNSLPKNQKITDSRYYTVRWKTNIPANTKYKMANS 923

  Fly   926 NN-----SGLHQNGLH------------------------HAQPYHPPGTPTLMHKR-----LDY 956
            ..     :||..|.|:                        .:.|..||...|::.|.     :..
Frog   924 TTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFESVPSSPPKDVTVVSKEGKPRTIIV 988

  Fly   957 HQQPP----------------------------PV------------------------------ 963
            :.|||                            ||
Frog   989 NWQPPSEANGKITGYIIYYSTDAQAELHDWVIEPVIGNRLTHQIQELTLDTPYYFKIQARNSKGM 1053

  Fly   964 -----------PPHSAYYQQAPTHQPSPMMERSVR-------GHQQPGGFHMEEGTPTP------ 1004
                       |..|:.|.  |..|.|.:..:.||       |....||.:...|.||.
Frog  1054 GPMSEAVLFRTPKESSPYM--PNDQASSISGKGVRPSDPGSNGGSSLGGSNSHHGNPTSLDQNML 1116

  Fly  1005 ----------------------TRIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNNNNNNLPP-- 1045
                                  :|..|...:::.:.::.|:.||       .:..|:.:..||
Frog  1117 LTIIVSIGVITVLIAVVIAAICSRRSSSHHKKKRAASKSVNGSH-------KYKGNSKDVKPPDL 1174

  Fly  1046 --HHQHLHHHPGHPGGLVGIPIVPGSPRVQRSPMPSRAMIKRTRLGSHTDNISSGSLNS 1102
              ||:.|...|........ ||:..:| :.|||.........|....|..:.|...|.|
Frog  1175 WIHHERLELKPTDKSPETN-PILTDTP-LPRSPQDLTPGDSTTESSIHQHSNSYRGLES 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boi	NP_001096868.3	IG_like	42..131	CDD:214653	24/97 (25%)
		IG_like	154..234	CDD:214653	18/89 (20%)
		Ig	172..234	CDD:299845	15/63 (24%)
		IG_like	249..329	CDD:214653	30/87 (34%)
		Ig	257..329	CDD:299845	29/79 (37%)
		IG_like	339..418	CDD:214653	22/79 (28%)
		Ig	352..408	CDD:299845	16/56 (29%)
		FN3	470..592	CDD:238020	20/121 (17%)
		FN3	613..700	CDD:238020	21/88 (24%)
neo1	XP_012821597.1	Ig1_Neogenin	48..142	CDD:143199	27/104 (26%)
		IG_like	152..233	CDD:214653	18/86 (21%)
		I-set	245..331	CDD:369462	33/92 (36%)
		Ig4_Neogenin	351..421	CDD:212460	19/74 (26%)
		FN3	453..545	CDD:238020	31/153 (20%)
		FN3	552..641	CDD:238020	21/97 (22%)
		FN3	649..740	CDD:238020	19/102 (19%)
		FN3	751..831	CDD:214495	12/83 (14%)
		FN3	869..962	CDD:238020	13/92 (14%)
		FN3	969..1064	CDD:238020	9/94 (10%)
		Neogenin_C	1169..1451	CDD:368988	17/65 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100