DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tko and MRPS12

DIOPT Version :9

Sequence 1:	NP_001245490.1	Gene:	tko / 31228	FlyBaseID:	FBgn0003714	Length:	154	Species:	Drosophila melanogaster
Sequence 2:	NP_066930.1	Gene:	MRPS12 / 6183	HGNCID:	10380	Length:	138	Species:	Homo sapiens

Alignment Length:	141	Identity:	79/141 - (56%)
Similarity:	90/141 - (63%)	Gaps:	17/141 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSDISNSFTSLPAI------QCSYETAVRGMASLQQMHRSGPHIKTRPPRQ--PLDGKPFAKGVV 76
            |..::.|.|..||:      .||       ||:|.||||.||  ..||||:  |.:|:|..||||
Human     7 LHGLNTSLTCGPALVPRLWATCS-------MATLNQMHRLGP--PKRPPRKLGPTEGRPQLKGVV 62

  Fly    77 LKTLIKKPKKPNSANRKCVLVRLSTGKEMVAYIPGIGHNLQEHNIVLCRVGRLQDVPGVKLKAVR 141
            |.|..:||||||||||||..||||||:|.|.:|||.||.||||.|||...||.||:|||||..||
Human    63 LCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVR 127

  Fly   142 GVYDLAHVVKK 152
            |.||..||.||
Human   128 GKYDCGHVQKK 138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tko	NP_001245490.1	Ribosomal_S12	46..152	CDD:239466	68/107 (64%)
MRPS12	NP_066930.1	Ribosomal_S12	32..138	CDD:239466	68/107 (64%)
MRPS12	NP_066930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..56		11/21 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6179
eggNOG	1	0.900	-	-		E1_COG0048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6848
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49546
OrthoDB	1	1.010	-	-		D1542634at2759
OrthoFinder	1	1.000	-	-		FOG0003097
OrthoInspector	1	1.000	-	-		oto88787
orthoMCL	1	0.900	-	-		OOG6_101451
Panther	1	1.100	-	-	LDO	PTHR11652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1260
SonicParanoid	1	1.000	-	-		X2071
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870