Protein Alignment gt and NFIL3

DIOPT Version :10

• Sequence 1: NP_525049.1
• Gene: gt / 31227
• FlyBaseID: FBgn0001150
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_005375.2
• Gene: NFIL3 / 4783
• HGNCID: 7787
• Length: 462
• Species: Homo sapiens
• Alignment Length: 139
• Identity: 36/139 - (25%)
• Similarity: 63/139 - (45%)
• Gaps: 20/139 - (14%)

  Fly   312 KMRRTNSRSGSVNEGSSSNN----NSE----SEDRAAAEESSDCDSQAGNFESKSATSSSSNLAN 368
            ||:.......|::..|:.:.    ||.    |||....||....:...|..:|.:.......:.:
Human     5 KMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPD 69

  Fly   369 ATAANSGISSGSQVKDAAYYERRRKNNAAAKKSRDRRRIKEDEIAIRAAYLERQNIELLCQIDAL 433
                        :.|||.|:|:|||||.|||:||::||:.:..:..:...|..:|..|..::.:|
Human    70 ------------EKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSL 122

  Fly   434 KVQLAAFTS 442
            |::....:|
Human   123 KLKFGLISS 131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gt	NP_525049.1	bZIP_HLF	383..440	CDD:269843	22/56 (39%)
		coiled coil	384..440	CDD:269843	21/55 (38%)
NFIL3	NP_005375.2	bZIP_NFIL3	72..131	CDD:269842	22/58 (38%)
		coiled coil	73..131	CDD:269842	21/57 (37%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	79..95		10/15 (67%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	99..106		0/6 (0%)
		Vert_IL3-reg_TF	130..461	CDD:368956	1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..237
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..302
		Necessary for transcriptional repression and sufficient for interaction with DR1. /evidence=ECO:0000269|PubMed:8836190	299..363