Protein Alignment gt and HLF

DIOPT Version :10

• Sequence 1: NP_525049.1
• Gene: gt / 31227
• FlyBaseID: FBgn0001150
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: XP_005257326.1
• Gene: HLF / 3131
• HGNCID: 4977
• Length: 296
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 74/354 - (20%)
• Similarity: 126/354 - (35%)
• Gaps: 124/354 - (35%)

  Fly   108 VETPRKTPSPYQTSYSYG----------SGSPSA------SPT---SNLLYAAQMQQQQHQQQQQ 153
            :|.|.|.|..::.::|..          |.||:.      .||   ..|.|.....|.::...::
Human    26 LENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEE 90

  Fly   154 QQQQQQQLASLYPAFYYSNIKQEQATPTAAPPKVTPTANLLQTFAAASAAAAAAAAASSTNSPR- 217
            ...:.    .:.|:       ..|...:..||.:.|         |:|||.:....:|..::|.
Human    91 FLSEN----GIPPS-------PSQHDHSPHPPGLQP---------ASSAAPSVMDLSSRASAPLH 135

  Fly   218 ---PASNASTMQIDVLENPLSPAVEAT-TPTTSSSGEAGKNTRPFKAFPRDPLVIAANFAATDVL 278
               |:.|.  ||..:....|.||...| :|....:.:......|      ||..:|.:......:
Human   136 PGIPSPNC--MQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP------DPADLALSSIPGQEM 192

  Fly   279 LDNPRVERYTEYRKRVLEQIRSSNGGSRTVTNPKMRRTNSRSGSVNEGSSSNNNSESEDRAAAEE 343
            .| ||..:::|...:....|:.    :|.|..|                   ::.:.:|:
Human   193 FD-PRKRKFSEEELKPQPMIKK----ARKVFIP-------------------DDLKQDDK----- 228

  Fly   344 SSDCDSQAGNFESKSATSSSSNLANATAANSGISSGSQVKDAAYYERRRKNNAAAKKSRDRRRIK 408
                                                       |:.||||||.|||:|||.||:|
Human   229 -------------------------------------------YWARRRKNNMAAKRSRDARRLK 250

  Fly   409 EDEIAIRAAYLERQNIELLCQIDALKVQL 437
            |::|||||::||::|..|..::..|:.:|
Human   251 ENQIAIRASFLEKENSALRQEVADLRKEL 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gt	NP_525049.1	bZIP_HLF	383..440	CDD:269843	28/55 (51%)
		coiled coil	384..440	CDD:269843	28/54 (52%)
HLF	XP_005257326.1	bZIP_HLF	226..284	CDD:269843	29/102 (28%)
		coiled coil	226..284	CDD:269843	29/102 (28%)