DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gt and DBP

DIOPT Version :9

Sequence 1:	NP_525049.1	Gene:	gt / 31227	FlyBaseID:	FBgn0001150	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001343.2	Gene:	DBP / 1628	HGNCID:	2697	Length:	325	Species:	Homo sapiens

Alignment Length:	374	Identity:	86/374 - (22%)
Similarity:	131/374 - (35%)	Gaps:	116/374 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KTPSPYQTSYSYGSGSPSASPTSN--LLYAAQMQQQQHQQQQQQQQQQQQLASLYPAFYYSNIKQ 175
            :||:|...      |.|:.:|...  ||....:.|...:.::             ||   |.:.:
Human     8 RTPAPLLL------GGPAGTPPGGGALLGLRSLLQGTSKPKE-------------PA---SCLLK 50

  Fly   176 EQATPTAAPPKVTPTANLLQTFAAASAAAAAAAAASSTNSPR---------------------PA 219
            |:....|.|...||...|    ..|..|.|.|.|.....|||                     |.
Human    51 EKERKAALPAATTPGPGL----ETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPF 111

  Fly   220 SNASTMQID--VLENPLSPA---------------VEATTPTTSSSGEAGKNTRPFKAFPRDPLV 267
            .:...:.:|  :||:.|.|:               ..|.:|...|.|.|...:.|..|..|..|.
Human   112 GDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAALG 176

  Fly   268 IAANFAA------TDVLLDNPRVERYTEYRKRVLEQIRSSNGGSRTVTNPKMRRTNSRSGSVNEG 326
            .|:...|      |...:|...||....:.....:...||..|..|. :|:..|.
Human   177 TASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETF-DPRRHRF---------- 230

  Fly   327 SSSNNNSESEDRAAAEESSDCDSQAGNFESKSATSSSSNLANATAANSGISSGSQVKDAAYYERR 391
                    ||:....:..           .|.|..              |....:.||..|:.||
Human   231 --------SEEELKPQPI-----------MKKARK--------------IQVPEEQKDEKYWSRR 262

  Fly   392 RKNNAAAKKSRDRRRIKEDEIAIRAAYLERQNIELLCQIDALKVQLAAF 440
            .|||.|||:|||.||:||::|::|||:||::|..|..::.|::.:|:.:
Human   263 YKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHY 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gt	NP_525049.1	bZIP_HLF	383..440	CDD:269843	28/56 (50%)
gt	NP_525049.1	coiled coil	384..440	CDD:269843	27/55 (49%)
DBP	NP_001343.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		26/116 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..200		15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..255		6/68 (9%)
		bZIP_HLF	254..313	CDD:269843	28/58 (48%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	257..279		14/21 (67%)
		coiled coil	258..309	CDD:269843	25/50 (50%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	283..297		7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910