Protein Alignment gt and CEBPB

DIOPT Version :10

• Sequence 1: NP_525049.1
• Gene: gt / 31227
• FlyBaseID: FBgn0001150
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_005185.2
• Gene: CEBPB / 1051
• HGNCID: 1834
• Length: 345
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 75/359 - (20%)
• Similarity: 124/359 - (34%)
• Gaps: 114/359 - (31%)

  Fly   159 QQLASLYPAFYYSNIKQEQATPTAAPP---KVTPTANLLQTFAAASAA----AAAAAAASSTNSP 216
            |:|.:..||          ..|...||   |....||........:||    ||.||..::...|
Human     2 QRLVAWDPA----------CLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGP 56

  Fly   217 RP--------ASNASTMQIDVLENPLSPAVEATTPTTSSSGEAGKNTRPFKAFPRDPLVIAANFA 273
            ||        ..:...:.......||. |.:|..|.|:        |..|:|.|..|....|:..
Human    57 RPPAGELGSIGDHERAIDFSPYLEPLG-APQAPAPATA--------TDTFEAAPPAPAPAPASSG 112

  Fly   274 ATDVLLDNPRVERYTEYRKRVLEQIRSSNGGSRTVTNP------KMRRTNSRSGSVNEGSSSNNN 332
                        ::.::    |..:.|.:.|.:....|      .:.|..:..|:::.|..:..:
Human   113 ------------QHHDF----LSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLH 161

  Fly   333 -------SESEDRA-AAEESSDCDSQ------------------------------AGNFESKSA 359
                   ..:|.:| ...|.:||..:                              :|:..|.|.
Human   162 PPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLST 226

  Fly   360 TSSSS-----NLANATAANSGISSG-----SQVKDAA----------YYERRRKNNAAAKKSRDR 404
            :||||     :.|:|.|..:...:|     ||||..|          |..||.:||.|.:||||:
Human   227 SSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDK 291

  Fly   405 RRIKEDEIAIRAAYLERQNIELLCQIDALKVQLA 438
            .:::..|...:...|..:|..|..:::.|..:|:
Human   292 AKMRNLETQHKVLELTAENERLQKKVEQLSRELS 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gt	NP_525049.1	bZIP_HLF	383..440	CDD:269843	18/66 (27%)
		coiled coil	384..440	CDD:269843	17/65 (26%)
CEBPB	NP_005185.2	Required for Lys-174 sumoylation	1..24		8/31 (26%)
		Required for MYC transcriptional repression. /evidence=ECO:0000250|UniProtKB:P28033	24..135		26/135 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..67		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..116		12/57 (21%)
		9aaTAD	116..124		1/11 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..178		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..271		16/52 (31%)
		bZIP_CEBPB	264..334	CDD:269860	16/62 (26%)
		coiled coil	271..332	CDD:269860	16/55 (29%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	275..295		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	297..304		1/6 (17%)