DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gt and CEBPB

DIOPT Version :9

Sequence 1:	NP_525049.1	Gene:	gt / 31227	FlyBaseID:	FBgn0001150	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_005185.2	Gene:	CEBPB / 1051	HGNCID:	1834	Length:	345	Species:	Homo sapiens

Alignment Length:	359	Identity:	75/359 - (20%)
Similarity:	124/359 - (34%)	Gaps:	114/359 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 QQLASLYPAFYYSNIKQEQATPTAAPP---KVTPTANLLQTFAAASAA----AAAAAAASSTNSP 216
            |:|.:..||          ..|...||   |....||........:||    ||.||..::...|
Human     2 QRLVAWDPA----------CLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGP 56

  Fly   217 RP--------ASNASTMQIDVLENPLSPAVEATTPTTSSSGEAGKNTRPFKAFPRDPLVIAANFA 273
            ||        ..:...:.......||. |.:|..|.|:        |..|:|.|..|....|:..
Human    57 RPPAGELGSIGDHERAIDFSPYLEPLG-APQAPAPATA--------TDTFEAAPPAPAPAPASSG 112

  Fly   274 ATDVLLDNPRVERYTEYRKRVLEQIRSSNGGSRTVTNP------KMRRTNSRSGSVNEGSSSNNN 332
                        ::.::    |..:.|.:.|.:....|      .:.|..:..|:::.|..:..:
Human   113 ------------QHHDF----LSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLH 161

  Fly   333 -------SESEDRA-AAEESSDCDSQ------------------------------AGNFESKSA 359
                   ..:|.:| ...|.:||..:                              :|:..|.|.
Human   162 PPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLST 226

  Fly   360 TSSSS-----NLANATAANSGISSG-----SQVKDAA----------YYERRRKNNAAAKKSRDR 404
            :||||     :.|:|.|..:...:|     ||||..|          |..||.:||.|.:||||:
Human   227 SSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDK 291

  Fly   405 RRIKEDEIAIRAAYLERQNIELLCQIDALKVQLA 438
            .:::..|...:...|..:|..|..:::.|..:|:
Human   292 AKMRNLETQHKVLELTAENERLQKKVEQLSRELS 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gt	NP_525049.1	bZIP_HLF	383..440	CDD:269843	18/66 (27%)
gt	NP_525049.1	coiled coil	384..440	CDD:269843	17/65 (26%)
CEBPB	NP_005185.2	Required for Lys-174 sumoylation	1..24		8/31 (26%)
		Required for MYC transcriptional repression. /evidence=ECO:0000250\|UniProtKB:P28033	24..135		26/135 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..67		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..116		12/57 (21%)
		9aaTAD	116..124		1/11 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..271		16/52 (31%)
		bZIP_CEBPB	264..334	CDD:269860	16/62 (26%)
		coiled coil	271..332	CDD:269860	16/55 (29%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	275..295		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	297..304		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810