Protein Alignment PsGEF and Arhgef10l

DIOPT Version :10

• Sequence 1: NP_996333.4
• Gene: PsGEF / 31224
• FlyBaseID: FBgn0264598
• Length: 2777
• Species: Drosophila melanogaster
• Sequence 2: NP_001277732.1
• Gene: Arhgef10l / 72754
• MGIID: 1920004
• Length: 1280
• Species: Mus musculus
• Alignment Length: 1508
• Identity: 269/1508 - (17%)
• Similarity: 442/1508 - (29%)
• Gaps: 527/1508 - (34%)

  Fly   451 AQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNS 515
            |.:.|||......|.|.:......|.|....:..:.|||..|            ..|.||.....
Mouse     2 ASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEE------------EDTSSGLVVPG 54

  Fly   516 AAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDP---PADGN 577
            .|...:.|...|..|::...|                                 |||   |....
Mouse    55 LAPERDTEPSLICFDTVPGSD---------------------------------LDPAAAPPQTE 86

  Fly   578 ANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMT 642
            |.:..:...|.|:                 ..||.||.|....|                    :
Mouse    87 APTVVSNGDAVGA-----------------AISGVRRSSWKRKS--------------------S 114

  Fly   643 KRLTRTEERGFGFSIVW---------THPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPE 698
            :|:.|.........:::         .|.|..|:   ||             ::.|.|......|
Mouse   115 RRIDRFTFPALEEDVIYDDVPCESPDAHQPGAER---GL-------------VYEDVHRAGAPRE 163

  Fly   699 ADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHT-----LAT 758
            .:.|....|:..|.:      ..:|..|....:..::......:|...:....|.:.     :..
Mouse   164 TEDLGWSSSEFESYS------EDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILA 222

  Fly   759 TATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIE----AAKRR---LHLPQVTFSKE- 815
            ...|...:..|:.....::..|..:      |.|||...:|    |..|:   ||...|....|
Mouse   223 LRVGGRDMQELKLKCDCKMTQLMKA------AKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEE 281

  Fly   816 ------------------SIVPVTDN-------RRRFLLQLISREQNFTAALHFGVDRFVQPLGE 855
                              .:.|:.|.       ||..|..::..|.::..:|...:..:..||.|
Mouse   282 EDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLME 346

  Fly   856 RK-DLISPNDHRTLFQNIDELL------RIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAIC 913
            .: ..:|....:.:|..:.|:|      :||  :..::...|..::...:..||   .|| :.:.
Mouse   347 MEPKALSARKCQVVFFRVKEILHCHSMFQIA--LSSRVAEWDSTEKIGDLFVAS---FSK-SMVL 405

  Fly   914 AAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAV-PRKRPDLTMFIHRPLQHFREILKLMQL 977
            ..|..|.|....| ..::.|:..|...|:.|:....| ...|..|...:.:|:|.|.:.:.|:|.
Mouse   406 DVYSDYVNNFTNA-MSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQD 469

  Fly   978 LAGNC---HVD--------TE---------EHKNFSTVINELQAAYREITVSSGLMEPLGEGRPL 1022
            :..|.   |.|        ||         |.|..:..:.|:|...:.::..|.|.:.|..|:..
Mouse   470 MLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQ 534

  Fly  1023 LTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVS------ 1081
            |.|           |:..|..|.|.:    |.|.:.:.|.|     .|.:|::|.|.::
Mouse   535 LLL-----------CETLTETVYGDR----GQLIKSKERRV-----FLLNDMLVCANINFKPSNH 579

  Fly  1082 RDRVLFITEEP------------IPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDL 1134
            |.::...:..|            :|...||:        ..:...|.|.:..|.:.      ...
Mouse   580 RGQLEISSLVPLGPKYVVKWNTALPQVQVVE--------VGQDGGTYDKDNLLIQH------AGA 630

  Fly  1135 TRTPKRGARRKSLILRAPSL--ELKAVWQNL-LQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPL 1196
            .:....|..:..:.|..|.|  ||:.:.::| :..||.|:.:.|..|                 .
Mouse   631 KKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGT-----------------Y 678

  Fly  1197 SDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGH 1261
            .::.:|.|....:.|..|  :.:|:::           :|||
Mouse   679 QNLNMTVAQDWCLALQRL--MRVKEEE-----------IHSA----------------------- 707

  Fly  1262 VEQIELLIDEKCRIL-------NKTGTPKS--------SALHLANWMKGQLDKQQQQARLAAIAR 1311
                     .|||:.       :|:|.|.|        :.|...:|:        .:..||.|..
Mouse   708 ---------NKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWV--------NRLHLAKIGL 755

  Fly  1312 SQENVSAEDEQLIFNSDSEQDERITYWTR------QQLEKRTKELNLAKENGGLSARP------N 1364
            .:||     :......|.::..:..:|..      .....||..|.|    |||...|      .
Mouse   756 REEN-----QPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQL----GGLVHSPVNSPLLG 811

  Fly  1365 F---------------GGKRLSG--VEELSMSATSDIYSTS------------------EAEGVT 1394
            |               ||:..:|  ||..|::..|.....|                  ||||.
Mouse   812 FSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGA- 875

  Fly  1395 SVISQSHSTTSDSQITVR---------SSPIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNS 1450
               .:|.:.| |..:||.         .|.::...:.....|...|:..||
Mouse   876 ---EESRAAT-DPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGP-------------- 922

  Fly  1451 SSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNR-----------TGTGTGSVTS 1504
              .|| ||    ::||.      ..|..|:...|..|.|:.|..           ...|.|.:.:
Mouse   923 --QPV-LC----LRHSP------FYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRT 974

  Fly  1505 MSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNP 1569
            :.|      |.....||...|.|      |....|.:..||.....|::|.........:|....
Mouse   975 LLS------LEDAAWASCGPRVT------VLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMA 1027

  Fly  1570 VITGSRLR--------HLDPPVSVSS-----LP-------------NGHCSAGVGGGSPKPLPPP 1608
            ..:||.:|        ||. .:::::     ||             .|....|...|....||.|
Mouse  1028 FSSGSSIRLFHTETLEHLQ-EINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP 1091

  Fly  1609 RRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACH 1673
            |                    ::.|..||              |.|..:..|..|  |..:.|..
Mouse  1092 R--------------------LEGIPKIT--------------GKGMVSLNGHCG--PVAFLAVA 1120

  Fly  1674 --------CRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAP 1730
                    .|...|:....|...||.:.|..:.:..|...|.....:::...|...|...|.| |
Mouse  1121 MSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHL-P 1184

  Fly  1731 AATLCGQERIPKE 1743
            ...|..:|..|.:
Mouse  1185 GPLLSVREPAPAD 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PsGEF	NP_996333.4	DUF4799	<99..209	CDD:318308
		C2	286..>381	CDD:425499
		PDZ_canonical	645..716	CDD:483948	12/79 (15%)
		RhoGEF	835..1007	CDD:470622	41/199 (21%)
		PRK12323	<2304..>2415	CDD:481241
Arhgef10l	NP_001277732.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		25/136 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..202		6/46 (13%)
		RhoGEF	315..499	CDD:238091	40/190 (21%)
		PH_19	524..679	CDD:465965	37/205 (18%)
		WD40_2	787..1278	CDD:465964	97/497 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1133..1163		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1207		3/12 (25%)