DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PsGEF and Doc2a

DIOPT Version :10

Sequence 1:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster
Sequence 2:NP_075226.1 Gene:Doc2a / 65031 RGDID:620518 Length:403 Species:Rattus norvegicus


Alignment Length:544 Identity:106/544 - (19%)
Similarity:164/544 - (30%) Gaps:201/544 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RGRRRGVGVPGVGDAN----KENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGP-- 79
            ||||        ||..    :|:..::....|        ::.:..:....|:|....||.|.  
  Rat     2 RGRR--------GDRMTINIQEHMAINVCPGP--------IRPIRQISDYFPRRGPGPEGGGGGR 50

  Fly    80 --RQATPQLAALRCLPRTT--GGAVALEDSQLSSSRMGDTTLDRML--DAIIESARKEVRC---- 134
              .:|...||.|...|...  |.....:.:::.|....|||....|  |.:.:.|...:.|    
  Rat    51 GFGEAPAHLAPLALAPPAALLGATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQASCMLHCRILR 115

  Fly   135 ------------------TKTLPGA----GATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRV 177
                              ...||||    ...|.|.....|..|:|            .|....:
  Rat   116 AKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNE------------ELTYSGI 168

  Fly   178 VRRKNPHKTTTINQTQSHQAKKLE-------PL-QLVPSTKR----CLSFSSSSASSDLDEDEQQ 230
            ......||...|:.....:....|       || :|.||.|:    ||              |:|
  Rat   169 TDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICL--------------ERQ 219

  Fly   231 VAKRSSLASPTTTPPSHCTTTTSSISS-----SSSSNGGADMEASQRGSIDVSIAFDAKEQQLNV 290
            |...|         ||..:.....||.     ..:..|...:|  :||.|.:|:::.::...|.|
  Rat   220 VPLPS---------PSSMSAALRGISCYLKELEQAEQGPGLLE--ERGRILLSLSYSSRRHGLLV 273

  Fly   291 HVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQ 355
            .::||..|...  ..||..:.|||..|.     |.....|.        .:|.|.:.:..|.|::
  Rat   274 GIVRCAHLAAM--DVNGYSDPYVKTYLR-----PDVDKKSK--------HKTCVKKKTLNPEFNE 323

  Fly   356 RFNFQISSGEETAGQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAK 420
            .|.:::.. ...|.:.|::.||..|                                     ..|
  Rat   324 EFFYEMEL-STLATKTLEVTVWDYD-------------------------------------IGK 350

  Fly   421 RSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQ 485
            .::|:|              |||.|           |.:|        |:.||...:..     .
  Rat   351 SNDFIG--------------GVSLG-----------PGAR--------GEAQKHWRDCL-----H 377

  Fly   486 QDDSPAEMAAAVTVTPQKPVATGS 509
            |.|:..|...  |:|.:.|.|.|:
  Rat   378 QPDTAVERWH--TLTSELPPAAGA 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsGEFNP_996333.4 DUF4799 <99..209 CDD:318308 26/145 (18%)
C2 286..>381 CDD:425499 22/94 (23%)
PDZ_canonical 645..716 CDD:483948
RhoGEF 835..1007 CDD:470622
PRK12323 <2304..>2415 CDD:481241
Doc2aNP_075226.1 Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250 1..92 22/105 (21%)
C2A_Rabphilin_Doc2 93..216 CDD:176000 24/134 (18%)
Interaction with UNC13D. /evidence=ECO:0000250 218..403 56/286 (20%)
C2B_Rabphilin_Doc2 257..389 CDD:176030 40/224 (18%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.