DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PsGEF and CG15803

DIOPT Version :9

Sequence 1:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	978	Identity:	182/978 - (18%)
Similarity:	297/978 - (30%)	Gaps:	375/978 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1686 LSPDKMEHQT--C-------KLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPA---------- 1731
            :.|..:::||  |       |||..|::.:..|.|   :...:...:..|..|.|
  Fly    92 VEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQ---NPSFATAAVAAAAAAAAAAGSGSDGDV 153

  Fly  1732 --------ATLCGQERIPKEENSTPTIAVVPPTPDSV------LTKTSTHVWDNSGCSSNGGGTS 1782
                    |:|.|..|....|.:  .::.|.|.|.:.      |::.:..:.|.......|||..
  Fly   154 GGGGVLDVASLVGLVRGGPAEGT--ELSAVEPQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGH 216

  Fly  1783 TTSTATTTTKQPRQAIIENIPEDSCDESPLD------EEPPYRPMSSALRRFGTMSSLEKLPSDD 1841
            :..|.:...::|            |....||      ..||.||            :|:.||.:.
  Fly   217 SMVTDSNAGQRP------------CPRLDLDIVPFSILSPPPRP------------ALQMLPLET 257

  Fly  1842 R----MDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSSGVIVNGEGLA 1902
            :    .|:...::..:                     |||:|.|:.|:.|.|:|          |
  Fly   258 QWRCVQDQNRHIETVI---------------------ADSKRKLLANEDGGSAS----------A 291

  Fly  1903 SGAWTNRAGAYVSDKMSFFEESRAFIDKY------LGRWNAGDAQQQHQ----------QGTASE 1951
            ||:.:       .|......|:..::.:.      ||...||...::..          :|:|:|
  Fly   292 SGSGS-------PDSYMDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAE 349

  Fly  1952 TDEQM---DECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMM 2013
            |..|:   |...:       |.|...||..| .|.::|:.               |.|....|.:
  Fly   350 TSGQIQINDRIVA-------VDGRSLSGVTN-HQAVELLR---------------NTDIVVHLTL 391

  Fly  2014 DELLMAPPMTASTIRGLLPRFYRRRLEPLFEEETESDEEKTQQDSDDIKKGEATTNGHYLEDSAG 2078
            :..|          ||       |:.|.|....||.             ||.:..:|  |:.|..
  Fly   392 ERFL----------RG-------RKYEHLQVALTEI-------------KGTSAPSG--LDRSQD 424

  Fly  2079 SSSDSE---SVPPAPPLVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPNLATSAMGP 2140
            ...|.|   |:|.:|.:.....:|.:..|      .:::|.|..|
  Fly   425 KDQDQESQLSMPGSPSIATLSWLPPKSLD------ADSIATEGDE-------------------- 463

  Fly  2141 RPLLTTRLLPTTAIDPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMTSSRPTPLSPAK 2205
                        |:|.:...:..|.. |::      .:|.||..
  Fly   464 ------------AVDAEYVGISGAED-EFI------ELPSRDTV--------------------- 488

  Fly  2206 AAATPIGMNATMTTKTTTTTMMTPSRAPSSTISTISSASDTTSSGGRASGRPPRFVP--PPPPPR 2268
                                        .|.:|.:...||  .|||....:.||..|  |....|
  Fly   489 ----------------------------ESNMSHVLDRSD--HSGGLTKDQVPRISPIVPLTNGR 523

  Fly  2269 RLLL-----TQTDLIAGQAKTELPRKKSGATADSGCSVAVGDAASASDPTA-IGSRTMPSTPSTS 2327
            .|:|     ..||....:.:||..:.:.|:..::.....:||..:.:||.. :....|| ||:..
  Fly   524 SLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMP-TPTNE 587

  Fly  2328 SLASAVAPKRPSSTIIETCLLGAPRPASATSSATASRMA-KPIRQSPPTQHQSQPRGQSCPAAVP 2391
            :...|.:|                       :|.:.|:| |.:             |.|....|.
  Fly   588 APVKAASP-----------------------TAASLRVAWKSL-------------GISLEGTVD 616

  Fly  2392 APSTAAPDAPTVPMPHAGCGLS--PRLEMRLALNHDILGDEDLICYEPGPDLTTILGHDLSTFHR 2454
            ..                ||:.  |...:|..|....:|.:.::  .||.:|..:..|.|.....
  Fly   617 VE----------------CGIEKRPHHYIRSILADGPVGRQGIL--RPGDELLQVNEHKLQGLRH 663

  Fly  2455 LTGRDLLSRSATNRVQPKEAVISYSQQRNSKMDTPTVNRRPRPLSAGAL--GGSTSNSNPNNSRS 2517
            :....:| :....||   :.|.:......|.::|   ::.|......:|  ||..|..|..:...
  Fly   664 IEVVKIL-KELPARV---KLVCARGTHVPSVINT---SQNPEAFETRSLLPGGHQSLQNLLSKAQ 721

  Fly  2518 SSSHGNSPLGGGLTRAGVEPVGQQQLVVQAGGGSAGRVGGGSGSAGGNSTACSSNRGGSKLGDLE 2582
            |.|...:.....||.||.           |.|||.|..|||:.|..      ..|..|..|...|
  Fly   722 SESSLYTSSTATLTDAGA-----------AAGGSGGTAGGGARSKS------LENVSGLALWSCE 769

  Fly  2583 ILA 2585
            :.|
  Fly   770 VTA 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	20/108 (19%)
		PDZ_signaling	605..680	CDD:238492	18/109 (17%)
		PDZ	773..858	CDD:214570	182/978 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900