DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PsGEF and bbg

DIOPT Version :9

Sequence 1:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster
Sequence 2:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster


Alignment Length:2976 Identity:524/2976 - (17%)
Similarity:914/2976 - (30%) Gaps:1050/2976 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 EVRCTKTLPGAGATTSTTILADNAEWSETSVHEM--EVRTPTHLKRQ----RVVRRKNPHKTTTI 189
            |:|..:|.|    |....:.....|..:.|:..|  ::.|||.|..:    ||...:.| ||.|.
  Fly   338 ELRSPETTP----TPKPRVQLATVEPKKRSIIPMPRKIPTPTKLPIEVTPPRVPILEEP-KTPTN 397

  Fly   190 NQTQSHQAK----KLEPLQL--VPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHC 248
            |:..|.:..    |..|:..  :|..|...:.:.......|...:||..:..|.....:||.:..
  Fly   398 NKVDSPKTPTNELKESPISATKIPKAKFSRAKTEGEIKLHLPAPKQQSPQSKSRIPIVSTPTAQK 462

  Fly   249 TT---TTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRD------LQRSHGS 304
            |.   .:.:::.:..|:....:...|:...|:         :||::..:.::      |||:: |
  Fly   463 TVPKPVSPTMNGTPLSSNIPRLLQKQKSETDL---------KLNLYRSKSKESSPRPPLQRAN-S 517

  Fly   305 GNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISS-GEETA 368
            .......::.|.|:|.::        |..|:.|                       :|| |..::
  Fly   518 AEAPERTFIPVLLNGNSK--------SSNSLES-----------------------VSSIGSSSS 551

  Fly   369 GQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAKRSEFLGCSTFPLN 433
            |              |||         |...|.:.:..||:..|:       :::.......|..
  Fly   552 G--------------NSV---------RSPKGPKPKPPERVQSLQ-------KTQIPKLQALPTT 586

  Fly   434 ELVHPDSGVSAGSYKLHAQACPPPTSRHS-----QPKANAGQDQKQETEAAKDQDKQQDDSPAEM 493
                |...:...|.:...|:  |||.|.:     .|.:|.....|.:|..:|.||:.:..|..::
  Fly   587 ----PPQQIPKLSMQTFKQS--PPTPRSTPVGTPSPTSNREIRFKIQTYESKTQDEDKLPSLFDL 645

  Fly   494 AAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRD 558
            ..:......|...:.|....||         |:..:.:...|...|.::...|:.:.|       
  Fly   646 VHSQENDKDKDRDSDSLKTHNS---------ITALLAAAAAEAADLSRESPPPLVVGK------- 694

  Fly   559 ADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHL-NNGTSGGRRQSTMPNSG 622
                 .::.::       :.|:||....::..:......:.||..:: .:|...|..:  :.|..
  Fly   695 -----CMKIVD-------DTNTTTCYTSSSSGEEDEDDLDASNREYICEDGEKLGPPE--LINGP 745

  Fly   623 GSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHP---PRVEKIEAGLSADRCGILPGDY 684
            |.|..                          .|::.| |.   |.:.::|...|:          
  Fly   746 GPSEA--------------------------YFNMFW-HSNMLPTIGEVEEEFSS---------- 773

  Fly   685 VIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGL 749
               ::..::...      ||::|: .|..|.....:..|...:|...:..::.. :||......:
  Fly   774 ---LEPQSLTNG------NLVKSE-ESKKLPKMEVNAGGLAQLTDDKIADHDAS-ATRADTRDEV 827

  Fly   750 GSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSK 814
            .:.: |...:::.:::|.|.:.||:||:.....|.|..:::||.|.           :|.|.|. 
  Fly   828 TTNQ-TQEISSSSSSSVKSQKTTTTTRVTTTKTSSSSSSSSCSSTV-----------IPDVAFK- 879

  Fly   815 ESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIA 879
                                               :||..||.|::|           :.:..|.
  Fly   880 -----------------------------------LQPYEERDDILS-----------EPITTIH 898

  Fly   880 ED---ILEQLCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEF 941
            |:   :.||...|:.:.::........|..:.:.:..|.:||..:.....|  |.::........
  Fly   899 EERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLD--LGDEQDMQEQPL 961

  Fly   942 IAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREI 1006
            .|.||:.:..|:|.:                         |..|.:                   
  Fly   962 TATITQESSLRERLE-------------------------CPQDNQ------------------- 982

  Fly  1007 TVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLA--VQGRQWI--FGGDLSRVEGRSVKPYW 1067
            ::..|.:.....|:   .|.:.|....:|:|:.....  ::|:|.:  .||.:|:.| .|.:|.:
  Fly   983 SIDRGTLTLSERGK---QLSEKEGLTTYTECETSEKESYLEGQQVLNGKGGFVSQDE-NSDQPTY 1043

  Fly  1068 TLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAP 1132
            ....|:.:........:|....|:...||....:  .:.|||.|.|.......:|.||       
  Fly  1044 EREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGA--KLLKKTDEERRLEQEAQKLIES------- 1099

  Fly  1133 DLTRTPKRGARRKSLILR--APSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVP 1195
             ..:..|...:...|.|.  ....:|.|..|                   :...|.|:|...:..
  Fly  1100 -YQKVKKEAEKLYKLELADDDQGFDLSAFEQ-------------------AEEEDKPEVSEEIKE 1144

  Fly  1196 LSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGG 1260
            :.|           ..|....|.::::.|  ..|...|.|                         
  Fly  1145 VKD-----------SQPVKVDIQIEEEVK--TPNQVIGEV------------------------- 1171

  Fly  1261 HVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIF 1325
            .||.:...|.|..::                        .||:      .:.:..||.::.:..|
  Fly  1172 KVEDVNKEIKETVQV------------------------SQQE------IKKEVKVSHQETKETF 1206

  Fly  1326 NSDSEQDE-----------RITYWTRQQLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMS 1379
            .|: |:||           ::|:   |.|.::.:|:...|          ...|.:..::|.:..
  Fly  1207 KSE-EKDESNELKIVKEEVKVTH---QDLREQIQEIEAVK----------VVHKEVKVIKESAKV 1257

  Fly  1380 ATSDIYSTSEAEGVTSVISQSHSTTSDSQITVRS-------SPIVLDKLAVCRHCHKNCQQ---- 1433
            .|    :||..:....||.......:||.:...|       ||.:.|.|....|.|....|    
  Fly  1258 TT----TTSHKQATKEVIISKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKHIIFPQEKVK 1318

  Fly  1434 --------------------------SGPGGARP---------GGGGGVNNSSSTPVLLCNSLKV 1463
                                      :.|..|.|         .|.||    ..||.....||:.
  Fly  1319 TAPTPLPKPKPKPPVPTNKPKMPVNLTKPKSAPPPVPSKRSELSGSGG----KPTPTQRRGSLET 1379

  Fly  1464 QHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETG 1528
                :.|.:  .|...|.|..:...|:...       .:.:::|..:..      ||.:|::.|.
  Fly  1380 ----AQPPK--PLERIIVGVEQRDEPEKPQ-------PIINLASVDLPN------VAPNSKQATV 1425

  Fly  1529 DTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHC 1593
            :| :.|.::..||:.....:..||  |........  |.|.:::||         |.||:..   
  Fly  1426 ET-TPVVEMPPDELQFESHQLPDD--GEKEKDLHQ--ESNDLLSGS---------SSSSVTT--- 1473

  Fly  1594 SAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATG 1658
                      |:..|......:.|          ..|::::.:.....|:.:..|........  
  Fly  1474 ----------PITTPILVSATSSM----------DSVQSVIEVVNGMPIISNQQTDDDDIDEV-- 1516

  Fly  1659 TGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQ------ 1717
                    |.|         :|..|.:....|...        |.|..|||...:|.|.      
  Fly  1517 --------AAY---------DDGMHLEAEGTKDVR--------PVQEVTTLTLDREHESDLGTLS 1556

  Fly  1718 ------LSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSS 1776
                  .|:..|..:...|||||...........:..|....|..|..:           ...||
  Fly  1557 NHHSNISSISGINASSNIPAATLISSSIKKTSTEAATTKPAAPQIPGKM-----------ELLSS 1610

  Fly  1777 NGGGTSTTSTAT------TTTKQ--------------------------------------PRQA 1797
            |.|.|:||:|||      |||||                                      |.:.
  Fly  1611 NTGTTTTTTTATHHLHQATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKV 1675

  Fly  1798 IIE---NIPEDSCDES---PLDEEPP--------YR--------PMSSALRRF------GTMSSL 1834
            ..|   .|.:...|||   ||.:..|        ||        |..|..|.:      ||    
  Fly  1676 TTELSYEIQKGGKDESSAPPLPKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGT---- 1736

  Fly  1835 EKLPSDDRMDEADE--LDDDLDSFKPNGHDGNSPQNEED-----DEDADSERALVQNDLGASSSS 1892
            .:.|||.|.||..|  :.|.:..|..|        ||.|     ...|....:..:..|..||  
  Fly  1737 PRKPSDWRKDEKSEKSVRDKIAMFSSN--------NELDAIPPAPATAPISSSFTRKPLNRSS-- 1791

  Fly  1893 GVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQQGTASETDEQMD 1957
                  |.|.....::.|.:..:..||.              .|..|.|:|:|...........|
  Fly  1792 ------ENLLDSCSSSSAPSLKTRAMSV--------------ENLNDVQRQYQLAKQLPQLHVAD 1836

  Fly  1958 ECTSGATSGEEVWGTPT----------SGGDNDDQDLQLINSENTHSSPTKSSTSLN----DDDD 2008
            ...|..|:      |||          .||              ::||..:...|.:    |..:
  Fly  1837 SMYSLNTA------TPTPSYASLPRRSHGG--------------SYSSGVERRISFSGEGGDAAN 1881

  Fly  2009 TELMMDELLMAPPMTASTIRGLLPRFYRRRLEPLFE-EETESD-EEKTQQDSDDIKKGE---ATT 2068
            .:..:..:|.....:.|.:|||:.....:.|||:.: .|.:|. :..:.:||.|...||   :|.
  Fly  1882 RKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGLGESHRSTV 1946

  Fly  2069 NGHYLEDSAGSSSDSESV---------------PPAPPLVPRPVVPDREEDPSAEGQQENLAMED 2118
            |.:....:.|::::..|:               |||.|                           
  Fly  1947 NRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQPPAKP--------------------------- 1984

  Fly  2119 QEDLHSSVERLLPNLATSAMGPRPLLTTRLLPTTAIDPQPPAVLVASSCEYLLDQRPSSVPGRDL 2183
                        |..:.:.:.||.::         |.|.||.          |||...:      
  Fly  1985 ------------PRTSLTPLQPRSMM---------IPPPPPP----------LDQESDT------ 2012

  Fly  2184 AGGSIGTTTMTSSRPTPLSPAKAAATPIGMNATMTTKTTTTTMMTPSRAPSSTISTISSASDTTS 2248
              .|:.:.|...:.|    |.|.|.|     .|::::|.|:       ..||..||::|.|   |
  Fly  2013 --DSVFSHTARVATP----PEKFALT-----RTLSSETNTS-------IASSNTSTLTSGS---S 2056

  Fly  2249 SGGRASGRPPRFVPPPPPPRRLLLTQTDLIAGQAKTELPRKKSGATADSGCSVAVGDAASASDPT 2313
            :|.:||.......|.....||:|.:|  :|.|:|                              .
  Fly  2057 AGSQASCSSLGSTPAVDLTRRVLKSQ--VINGEA------------------------------V 2089

  Fly  2314 AIGSRTMPSTPSTSSLASAVAPKRPS--------STIIETCLLGAPRPASATSSATASRMAKPIR 2370
            |:.||       .|.||||......|        ||..|.|.|             |:|..|||.
  Fly  2090 ALSSR-------KSILASAKCRSAKSRGQEEDNDSTDGEACSL-------------ANRRMKPIS 2134

  Fly  2371 QSPPTQHQSQPRGQSC------PAAVPAPSTAAPDAPTVPMPHAGCGLSPRLEMRLALNHDILGD 2429
            .....|.|.|...|..      .||....::...|:            |.|.:....::...:.:
  Fly  2135 SYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDS------------SRRSDTPAKISAMFIDE 2187

  Fly  2430 EDLICYEPGPD------LTTILGHDLSTFHRLTGRDLLSRSATNRVQPK--EAVISYSQQRNSKM 2486
            |....::..|:      :..:....|........|:.|.:..|..::.|  .:..:.:|.:|...
  Fly  2188 ERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSP 2252

  Fly  2487 DTPTVNRRPR--------PLSAGALGGSTSNSNPNNSRSSSSHGNSPLGGGLTRAGVEPVGQQQL 2543
            ....|.::|.        .|::.:.|.|::..|.:.::.:::...|....|..::.:.....||:
  Fly  2253 VIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQI 2317

  Fly  2544 VVQAG------------------GGSAG-RVGGGSGSAG---------GNSTACSSNRGGSKLGD 2580
            |.:|.                  ..|.| .:.|||....         .|:.|....|  .|.||
  Fly  2318 VEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGR--LKKGD 2380

  Fly  2581 ---------LEILARREKIYSMSQSRSGCRVRETTSTTTLMAMATEMRSGMDSEKRDSSWPKRAA 2636
                     :..|..||.|..:...|....:..|.|.:.::...|:.||.:.|....:..|....
  Fly  2381 RILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELD 2445

  Fly  2637 AAASLTRTRSSTSMD----------GAGAISTTTTT-TTTMTEEAFLETEVGRSKRLINFIKRRN 2690
            ........::|.|:|          |...::||.:| :.:..:.|.|..|              :
  Fly  2446 YERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDE--------------D 2496

  Fly  2691 SEITASSTSSTPNFSDGAIGEQPQPSHSQSSLLLQKLPPG--------QSQAQDS---------V 2738
            :|.|.:...:....|.|      ..:...:|.||::....        ::||:|:         |
  Fly  2497 AEATIAGIRARRQLSRG------DAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCV 2555

  Fly  2739 EMAQMSPRKDN-----------DKPSLNRRLWKQITKR-------RRTNSV 2771
            |:.     ||:           |.|..||.|   |.|:       ::||.|
  Fly  2556 EIV-----KDSCGLGFSIEGGFDSPLGNRPL---IVKKVFMGGAAQKTNQV 2598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsGEFNP_996333.4 DUF4799 <102..209 CDD:292674 23/89 (26%)
C2 286..>381 CDD:278593 16/101 (16%)
PDZ_signaling 644..716 CDD:238492 11/74 (15%)
RhoGEF 831..1000 CDD:295373 24/171 (14%)
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 6/32 (19%)
PDZ_signaling 2331..2413 CDD:238492 16/83 (19%)
PDZ_signaling 2553..2634 CDD:238492 14/54 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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