DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PsGEF and Rph

DIOPT Version :9

Sequence 1:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	62/294 - (21%)
Similarity:	109/294 - (37%)	Gaps:	68/294 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EMEVRTP-THLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLDE 226
            ::.:.|| .|.|..|..|.|..|||......::.|...:||.:|..|......|.......|.
  Fly   394 KLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHDF-- 456

  Fly   227 DEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSS---------NGGADMEAS-QRGSIDVSIAF 281
                      |.:...     |.:|..|.|....|         :..|:|..: ..|.:.:|:.:
  Fly   457 ----------LGAAKV-----CLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCY 506

  Fly   282 DAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHR 346
            :.|.:.|.|:|.:|.:|...  ..|||.:.:||:.|...|.             .:...:|:|..
  Fly   507 NTKRRALVVNVKQCINLMAM--DNNGSSDPFVKIQLKPDAH-------------KNKKHKTSVKW 556

  Fly   347 HSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAK 411
            .:..|.:::.|.|: :|..:...:.|.|.||.:|..      ..:::...::.|.:.: .|||
  Fly   557 RTLNPIYNEEFYFE-ASPHDLNKEMLILTVWDKDLG------KSNDFLGSLQLGAQSK-GERL-- 611

  Fly   412 LENAGNEAKRSEFLGCSTFP--LNELVH---PDS 440
                      .::|.|...|  .:|..|   ||:
  Fly   612 ----------QQWLDCIRLPDHFHEKWHCLAPDN 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674	14/46 (30%)
		C2	286..>381	CDD:278593	22/94 (23%)
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	22/99 (22%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	34/166 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1013
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900