Protein Alignment PsGEF and Grid2ip

DIOPT Version :10

• Sequence 1: NP_996333.4
• Gene: PsGEF / 31224
• FlyBaseID: FBgn0264598
• Length: 2777
• Species: Drosophila melanogaster
• Sequence 2: NP_001152793.1
• Gene: Grid2ip / 170935
• MGIID: 2176213
• Length: 1203
• Species: Mus musculus
• Alignment Length: 1506
• Identity: 274/1506 - (18%)
• Similarity: 446/1506 - (29%)
• Gaps: 582/1506 - (38%)

  Fly   653 FGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIF 717
            |||.:..:.|..|.::..|.||...|:.|||.::.|:...|..:....::.|.|.
Mouse    12 FGFQLGGSGPCFVIEVAEGSSAHAGGLRPGDQILEVEGLAVGGLSRERIVRLARR---------- 66

  Fly   718 RRSGAGATTITSTDLGQNNVHISTRLGAAVGL--GSEEHTLATTATGTTTVMSLQRTTSTRIQPL 780
                                  ..|:..::|:  |.|....|.||...|....       |..||
Mouse    67 ----------------------CPRVPPSLGVLPGPEGGPTALTAAWLTRRFG-------RSLPL 102

  Fly   781 ANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFG 845
            :..:.|.|   .|........:||....:.:...:.|:..         :|.::||.|||...|.
Mouse   103 SRELLRLA---GGPRPDAVHRERRRKAQEFSCQVDDILGD---------RLTAKEQVFTALKQFA 155

  Fly   846 VDRFVQ----------------PLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQ 894
            .::.|.                |:.:...:..|..||..|..:     :::.:|.:||.:.:...
Mouse   156 AEQRVDELVWTLTLVLPSEAQGPVLDNLRIFIPKKHRARFDEV-----VSQGLLGKLCRARRAQG 215

  Fly   895 EPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTM 959
                  |.|:..|::.             :|.:.:||:             |..:...:|||
Mouse   216 ------AQRLRRSRSE-------------ERPERLLVS-------------TRASAAPRRPD--- 245

  Fly   960 FIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLT 1024
               .|...     |...||.|.                                  .|.|.|..|
Mouse   246 ---EPPPR-----KATSLLGGR----------------------------------TGPGGPRRT 268

  Fly  1025 LQDLESRMVFTKCKPFTLAVQGRQWI---FGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVL 1086
            ::..:....|    .|||...|..||   ..|  |..|..|:|                |.||:|
Mouse   269 VRVYKGNKSF----GFTLRGHGPVWIESVLPG--SPAENASLK----------------SGDRIL 311

  Fly  1087 FITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRA 1151
            |:        |.:|    ||.                      |:.|...:..:|:.      ..
Mouse   312 FL--------NGLD----MRN----------------------CSHDKVVSMLQGSG------AM 336

  Fly  1152 PSLELKAVWQNLLQRQIFLVNAALGSTPLSS---PLDSP---DVLNTLVPLSDIGLTTASMGSMK 1210
            |:|.::.                 |..|.:|   .||||   ..|.:|..::||
Mouse   337 PTLVVEE-----------------GPVPFASDSDSLDSPTRASALTSLQWVADI----------- 373

  Fly  1211 LPSLDSIHLKQQQKQQRTNNSHGHVHSAT-----GVATDRTADRSHGHNHGIHGGHVEQIELLID 1270
            |||  ||.::.:...|:.:      |..|     ||.  |..:|...|.:         |:.||.
Mouse   374 LPS--SIRVQGRTFSQQLD------HLLTPPERYGVC--RALERFFQHRN---------IDTLIV 419

  Fly  1271 EKCRILNKTGTPKSSAL-----HLANWMKGQLDKQQQQARL--AAIARSQENVSAEDEQLIFNSD 1328
            :...:|:   ||....|     .|..:.:.:|.:::....|  .|:...:.::..|.|.....:.
Mouse   420 DVYPVLD---TPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAMTEPESSLDLEPESTPEPTP 481

  Fly  1329 SEQDE---RITYWTRQQLEKRTKELNLAKENGGLSAR--PNFGGKRLSGVEELSMSAT------S 1382
            ..|..   |.:...|:.|..:..|.:|:...|.....  |...|:|.:| :..|:..|      |
Mouse   482 EPQPRSSLRASSMCRRSLRSQGLETSLSCGPGDCPEMPLPLIPGERQAG-DGTSLPETPNPKMMS 545

  Fly  1383 DIYSTSEA------EGVTSVISQSHSTTSDSQITVRSSPIVL-------DKLAVCRHCHKNCQQS 1434
            .:|:..|:      :|....:|:|.::.....:...|.|..|       |:|.........|.
Mouse   546 AVYAELESRLNSSFKGKIGTMSKSRASPPVPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCS-- 608

  Fly  1435 GPGGARPGGGGGVNNSSSTPVLLCNSLKVQ---------HSQSSPNRCCKLSNGIAGATEMANPK 1490
                   ||....::|.|.|....:|.:..         |:.|.|            :.:...|.
Mouse   609 -------GGLASPSSSESHPYASLDSSRAPSPQPGLGSIHADSPP------------SPDPIRPP 654

  Fly  1491 NSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVG 1555
            :..:....:..|.|..:......||.::         |...|.|...:|.|....:....||...
Mouse   655 SRRKLFAFSRPVRSRDTDRFLDALSEQL---------GPRLSIVDDFLTPENDYEEMSFHDDQGS 710

  Fly  1556 AMPNSSRSAG-------EGNPVITGSRLRHLDPPVSV----------SSLPNGHCSAGVGG---- 1599
            .:.|...||.       ||:.:...|...|:.||...          ...|:...|.|..|
Mouse   711 FVTNERSSASECVSSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDPKPSSRTSDGPRGPPQS 775

  Fly  1600 --------------GSPKPLPPP--------------RRTRV----------------------- 1613
                          ..|.|||||              ||:..
Mouse   776 LTKPLTQINHPVPPPPPPPLPPPVPCAPPMLSRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQ 840

  Fly  1614 ---------VAQM-----------CQEPPRPKANQQ---VKAIVTITETARIMRSSPTKGSGSGS 1655
                     ::.|           .|:||:|....:   .|.:|.|....:...:|
Mouse   841 LGEDSDYDKLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTS--------- 896

  Fly  1656 ATGTGSVGGSPAKYAACHCRCTPEDFTH---------------AQL---SPDKMEHQ-------- 1694
                         ....|.:.||.:...               |||   :||..|.|
Mouse   897 -------------ILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREA 948

  Fly  1695 ----------TCKLLESPKQTT--------TTLEQKQED--------EQLSLMLIGLAQLAPAAT 1733
                      ..::|..|:..|        .||::|.|:        .|.||.|....:||....
Mouse   949 PGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILE 1013

  Fly  1734 LC---------GQERIPK----------EENSTPTIAVVPPTPDS------VLTKT-STHVWDNS 1772
            ..         ||.:..|          |.|||.|:       |.      :|.|: |.|..:..
Mouse  1014 FVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTV-------DGKSTFLHILAKSLSQHFPELL 1071

  Fly  1773 GCSSNGGGTSTTSTATTTTKQPRQAIIENIPE--DSCDE--------SPLDEEPPYRPMSSALRR 1827
            |.:.:      ..|.....|..::|:..::.:  |:..|        :|..|:.....|:|.|..
Mouse  1072 GFAQD------LPTVPLAAKVNQRALTGDLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLET 1130

  Fly  1828 FGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEE-----DDEDADSERALVQNDLG 1887
              ...:|..|....| :..:||...|..|   |.|..:..:|.     .:..:..||||  :||.
Mouse  1131 --AQPALRALDGLQR-EAMEELGKALAFF---GEDSKATTSEAFFGIFSEFMSKFERAL--SDLQ 1187

  Fly  1888 ASS---SSGVI 1895
            |..   |||::
Mouse  1188 AGDGPRSSGMV 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PsGEF	NP_996333.4	DUF4799	<99..209	CDD:318308
		C2	286..>381	CDD:425499
		PDZ_canonical	645..716	CDD:483948	16/62 (26%)
		RhoGEF	835..1007	CDD:470622	30/187 (16%)
		PRK12323	<2304..>2415	CDD:481241
Grid2ip	NP_001152793.1	PDZ1_L-delphilin-like	2..77	CDD:467225	18/96 (19%)
		HN_L-delphilin-R1_like	122..201	CDD:259820	16/92 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..270		19/131 (15%)
		PDZ2_L-delphilin-like	269..342	CDD:467226	26/134 (19%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	18/98 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..541		15/75 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..586		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..656		8/56 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..821		21/110 (19%)
		FH2	812..1180	CDD:396655	68/408 (17%)