DRSC/TRiP Functional Genomics Resources

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Protein Alignment PsGEF and Doc2a

DIOPT Version :10

Sequence 1:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster
Sequence 2:NP_034199.1 Gene:Doc2a / 13446 MGIID:109446 Length:405 Species:Mus musculus


Alignment Length:540 Identity:107/540 - (19%)
Similarity:163/540 - (30%) Gaps:191/540 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RGRRRGVGVPGVGDAN----KENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQ 81
            ||||        ||..    :|:..::....|.  ..:..:.|.....|..|:......|:|..:
Mouse     2 RGRR--------GDRMTINIQEHMAINVCPGPI--RPIRQISDYFPRRGPGPEGGGGGGGTGCGE 56

  Fly    82 ATPQLAALRCLPRTT--GGAVALEDSQLSSSRMGDTTLDRML--DAIIESARKEVRC-------- 134
            |...||.|...|...  |.....:.:::.|....|||....|  |.:.:.|...:.|        
Mouse    57 APAHLAPLALAPPAALLGATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQASCMLHCRILRAKGL 121

  Fly   135 --------------TKTLPGA----GATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRK 181
                          ...||||    ...|.|.....|..|:|            .|....:....
Mouse   122 KPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNE------------ELTYSGITDDD 174

  Fly   182 NPHKTTTINQTQSHQAKKLE-------PL-QLVPSTKR----CLSFSSSSASSDLDEDEQQVAKR 234
            ..||...|:.....:....|       || :|.||.|:    ||              |:||...
Mouse   175 ITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICL--------------ERQVPLP 225

  Fly   235 SSLASPTTTPPSHCTTTTSSISS-----SSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIR 294
            |         ||..:.....||.     ..:..|...:|  :||.|.:|:::.::...|.|.::|
Mouse   226 S---------PSSMSAALRGISCYLKELEQAEQGPGLLE--ERGRILLSLSYSSRRHGLLVGIVR 279

  Fly   295 CRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNF 359
            |..|...  ..||..:.|||..|.     |.....|.        .:|.|.:.:..|.|::.|.:
Mouse   280 CAHLAAM--DVNGYSDPYVKTYLR-----PDVDKKSK--------HKTCVKKKTLNPEFNEEFFY 329

  Fly   360 QISSGEETAGQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAKRSEF 424
            :|.. ...|.:.|::.||..|                                     ..|.::|
Mouse   330 EIEL-STLATKTLEVTVWDYD-------------------------------------IGKSNDF 356

  Fly   425 LGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDS 489
            :|              |||.|           |.:|        |:.||...:..     .|.|:
Mouse   357 IG--------------GVSLG-----------PGAR--------GEAQKHWNDCL-----HQPDT 383

  Fly   490 PAEMAAAVTVTPQKPVATGS 509
            ..|...  |:|.:.|.|.|:
Mouse   384 ALERWH--TLTSELPPAAGA 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsGEFNP_996333.4 DUF4799 <99..209 CDD:318308 26/145 (18%)
C2 286..>381 CDD:425499 23/94 (24%)
PDZ_canonical 645..716 CDD:483948
RhoGEF 835..1007 CDD:470622
PRK12323 <2304..>2415 CDD:481241
Doc2aNP_034199.1 Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250 1..94 22/101 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..54 4/19 (21%)
C2A_Rabphilin_Doc2 95..218 CDD:176000 24/134 (18%)
Interaction with UNC13D. /evidence=ECO:0000250 220..405 57/286 (20%)
C2B_Rabphilin_Doc2 259..391 CDD:176030 41/224 (18%)
Blue background indicates that the domain is not in the aligned region.

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