DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and KSR1

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001381512.1	Gene:	KSR1 / 8844	HGNCID:	6465	Length:	928	Species:	Homo sapiens

Alignment Length:	857	Identity:	203/857 - (23%)
Similarity:	334/857 - (38%)	Gaps:	223/857 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DPLAEELHNVQ--LVKHVTR-----------ENIDALNA--KFAN-----------LQEPPAMYL 53
            |...:|:..::  ||:::.:           |....||:  :|::           :||.|
Human    67 DLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEIP---- 127

  Fly    54 IEYQELT--SKLHELEAKEQELMERLNSQDQQ------------EDSSLVERFKEQPHYQNQTQI 104
               ::||  :.|...|||.:|.:.|..:...:            :.:.|....||...:.:
Human   128 ---RDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSS---- 185

  Fly   105 LQQQRQLARVHHGNDLTDSLGS-----QPGS----QCGTLTRQPKILLRAHLPNQQRTSVEVISG 160
            |..:|:..    ....||:|.:     .|||    :.|...:.|:.:..:.||.....:.....|
Human   186 LDARRESG----SGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEG 246

  Fly   161 VRLCDALMKALKLRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHV-----EEIFVRLLDKFPIRTH 220
              |.|..:......:|||.......|......:..||.:.....     .::| :||..||..|.
Human   247 --LSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVF-QLLPSFPTLTR 308

  Fly   221 IK-------------------------------------HQIIRKTFFSLVFCEGCRRLLFTGFY 248
            .|                                     |:...|::.|.| |..|::.:..|..
Human   309 SKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQV-CHVCQKSMIFGVK 372

  Fly   249 CSQCNFRFHQRCANRVPMLC-------------QPFPMDSYYQLLLAENPDNGVGFPGRGTAVR- 299
            |..|..:.|.:|....| .|             :..|.|       ..||.:....|..||..:
Human   373 CKHCRLKCHNKCTKEAP-ACRISFLPLTRLRRTESVPSD-------INNPVDRAAEPHFGTLPKA 429

  Fly   300 ----------------FNMSSRSRSRRCS------SSGSSSSSKPPSSSSG-------------- 328
                            .|.||.:.|...|      ||..||::.||:.|.|
Human   430 LTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFI 494

  Fly   329 NHRQ------------GRP-PRISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTD 380
            :|||            ..| |..:...|.:..|...:.......:|...:...:|.        |
Human   495 HHRQQFIFPDISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAE--------D 551

  Fly   381 HSNSTQASPTSTLKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYR 445
            ..:.....|:|......|.:|.|.:::..|         :.|:|..|::.:|..||.|.:|.|:|
Human   552 DEDEVDDLPSSRRPWRGPISRKASQTSVYL---------QEWDIPFEQVELGEPIGQGRWGRVHR 607

  Fly   446 AHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSL 509
            ..|||.||::.|.:...:...|:.||.||...::|||.|::|||| |::.|.|||:|.:|:|.:|
Human   608 GRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTL 672

  Fly   510 YKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKT 574
            :..|...:|...:|....|.:::.:||.|||||.|:|:||||.|:| :::..|.|.||||.....
Human   673 HSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YDNGKVVITDFGLFGISG 736

  Fly   575 RWSGEKQANQPTGSILW---MAPEVIRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGH 630
            .....::.||...|..|   :|||::|.      ::..|:|..:||||||.|.|||.|...|
Human   737 VVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP--- 798

  Fly   631 ISNK--DQILFMVGRGLLRPDMSQVRSDAP--QALKRLAEDCIKYTPKDRPLFRPLLNMLENMLR 691
            :.|:  :..::.:|.|   ..|.:|.:...  :.:..:...|..:..::||.|..|::|||.
Human   799 LKNQAAEASIWQIGSG---EGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEK--- 857

  Fly   692 TLPKIHRSASEP 703
             |||::|..|.|
Human   858 -LPKLNRRLSHP 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	12/74 (16%)
		C1_Raf	221..269	CDD:410361	14/97 (14%)
		STKc_Raf	435..687	CDD:270964	92/265 (35%)
KSR1	NP_001381512.1	C1	348..390	CDD:197519	12/43 (28%)
KSR1	NP_001381512.1	STKc_KSR1	590..868	CDD:271054	100/288 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910