DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and VIK

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_172853.1	Gene:	VIK / 837960	AraportID:	AT1G14000	Length:	438	Species:	Arabidopsis thaliana

Alignment Length:	309	Identity:	101/309 - (32%)
Similarity:	153/309 - (49%)	Gaps:	61/309 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 NWNILAEEILI--GPRIGSGSFGTVYRAHWHG-PVAVKTLNVKTPSPAQ----LQAFKNEVAMLK 478
            :|.|...|:..  ...||.||||.:.:|:|.| |||||.:   .||.:.    :|.|::||.:|.
plant   152 DWEIEPAELDFSNAAMIGKGSFGEIVKAYWRGTPVAVKRI---LPSLSDDRLVIQDFRHEVDLLV 213

  Fly   479 KTRHCNILLFMGCVS--KPSLAIVTQWCEGSSLYKHVHVSETKFKL--NTLIDIGRQVAQGMDYL 539
            |.||.||:.|:|.|:  || |.::|::..|..|::::   :.|..|  .|.::....:|:||.||
plant   214 KLRHPNIVQFLGAVTERKP-LMLITEYLRGGDLHQYL---KEKGGLTPTTAVNFALDIARGMTYL 274

  Fly   540 HAKN--IIHRDLKSNNIFLHEDLS--VKIGDFGLATA--------KTRWSGEKQANQPTGSILWM 592
            |.:.  |||||||..|:.|....:  :|:|||||:..        ..:.:||      |||..:|
plant   275 HNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGE------TGSYRYM 333

  Fly   593 APEVIRMQELNPYSFQSDVYAFGIVMYELL------AECLPY---GHISNKDQILFMVGRGLLRP 648
            ||||.:.:.   |..:.||::|.:::||:|      |...||   .|:|:..:..|. .:| ..|
plant   334 APEVFKHRR---YDKKVDVFSFAMILYEMLEGEPPFANHEPYEAAKHVSDGHRPTFR-SKG-CTP 393

  Fly   649 DMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIH 697
            |           |:.|...|.......||.|..:|..||.:..|||..|
plant   394 D-----------LRELIVKCWDADMNQRPSFLDILKRLEKIKETLPSDH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	92/281 (33%)
VIK	NP_172853.1	ANK repeat	36..68	CDD:293786
		PTZ00322	45..>126	CDD:140343
		ANK repeat	70..101	CDD:293786
		ANK repeat	103..127	CDD:293786
		STKc_MAP3K-like	168..420	CDD:270901	92/280 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010