DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and AT2G31010

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001189646.1	Gene:	AT2G31010 / 817652	AraportID:	AT2G31010	Length:	775	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	177/785 - (22%)
Similarity:	314/785 - (40%)	Gaps:	206/785 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DPLAEELHNVQLVKHVTRENIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKEQELMERLNS 79
            |...:||:|    :..|...:.||..:...::    :.|:::|: ..||    |..::|:..|.|
plant    76 DKRVKELYN----RLPTPSELHALGEEGVRIE----VILVDFQK-DKKL----AMLKQLITTLVS 127

  Fly    80 QDQQEDSSLVER-------FKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTR 137
            ......:.::::       |.::|..::.:::..::......:||..|   ||......|.....
plant   128 GSGTNPALVIKKIAGTVSDFYKRPTLESPSKLALEENAFLFENHGAQL---LGQIKRGCCRARAI 189

  Fly   138 QPKIL---------LRAHLP----------NQQRTSVEVISGVRLCDALM-----------KALK 172
            ..|:|         |...||          |:..:.:.|::.|.|...|:           ||:.
plant   190 LFKVLADTVGLESRLVVGLPSDGTVNCMDSNKHMSVIVVLNSVELLVDLIRFPGQLVPRSAKAIF 254

  Fly   173 LRQLTP---------DMCEVSTTHSGRHIIPWHTDIGTLHVEEI-FVRLLDKFP----------- 216
            :..::|         |.|: |.......:........|...|.: |.|.|:.:|
plant   255 MSHISPAGESDSAENDSCD-SPLEPNSPLYERRDPESTEKDENLQFYRKLEGYPNASGSSLRSLM 318

  Fly   217 IR--THIKHQIIRKTF----FSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDS 275
            :|  |.|:.::...:.    .:.||....||.:..           .||.|:..|
plant   319 LRPSTAIERKLSNTSHSEPNVATVFWRRSRRKVIA-----------EQRTASSSP---------- 362

  Fly   276 YYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSSSGSSS-------SSKPPSSSSGNHRQG 333
                   |:|                  |..|.|...|:|.:|       :|.|.|||:...|:.
plant   363 -------EHP------------------SMRRGRSMLSTGRNSFRDYTGEASSPSSSSTSEIRKT 402

  Fly   334 R------PPRISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTD------------ 380
            |      .|.|..|..|         .:|.:..:.:::.::|.|........|
plant   403 RRRSFRITPEIGDDIAS---------AVREMYEKSKQNRLLQGREDENSSVIDNNVSGLHLDDEL 458

  Fly   381 HSNSTQASPTS-------TLKHNRPR-----------ARSADESNKNLLLRDAKSSEENWNILAE 427
            :|..|.:.|:|       |.....|.           ..|:...|:.||      ..:.|:|...
plant   459 NSKKTMSLPSSPHAYRCQTFGRRGPSEFAVKDTWNKVVESSTLQNQPLL------PYQEWDIDFS 517

  Fly   428 EILIGPRIGSGSFGTVYRAHWHG-PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG- 490
            |:.:|.|:|.|.||.|:|..|:| .||:|....:..:...::.|.||:::|.:.||.|::||:|
plant   518 ELTVGTRVGIGFFGEVFRGVWNGTDVAIKLFLEQDLTAENMEDFCNEISILSRVRHPNVVLFLGA 582

  Fly   491 CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKL--NTLIDIGRQVAQGMDYLHAKNIIHRDLKSNN 553
            |...|.|:::|::.|..|||..:|:|..|.||  :..:.:.|.:.:|:..:|...|:||||||.|
plant   583 CTKPPRLSMITEYMELGSLYYLIHMSGQKKKLSWHRRLRMLRDICRGLMCIHRMKIVHRDLKSAN 647

  Fly   554 IFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVM 618
            ..:.:..:|||.||||:...|  ....:.....|:..|||||:||.:   |::.:.|:::.|::|
plant   648 CLVDKHWTVKICDFGLSRIMT--DENMKDTSSAGTPEWMAPELIRNR---PFTEKCDIFSLGVIM 707

  Fly   619 YELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRP----LF 679
            :||.....|:..:. .::::|.|.....|.::    .|.|  |.:|..||.. .|::||    :.
plant   708 WELSTLRKPWEGVP-PEKVVFAVAHEGSRLEI----PDGP--LSKLIADCWA-EPEERPNCEEIL 764

  Fly   680 RPLLN 684
            |.||:
plant   765 RGLLD 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	19/109 (17%)
		C1_Raf	221..269	CDD:410361	9/51 (18%)
		STKc_Raf	435..687	CDD:270964	83/258 (32%)
AT2G31010	NP_001189646.1	EDR1	48..245	CDD:405130	33/184 (18%)
AT2G31010	NP_001189646.1	STKc_MAP3K-like	525..764	CDD:270901	80/251 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010