DRSC/TRiP Functional Genomics Resources

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Protein Alignment Raf and RAF1

DIOPT Version :9

Sequence 1:NP_001096867.3 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_001341618.1 Gene:RAF1 / 5894 HGNCID:9829 Length:668 Species:Homo sapiens


Alignment Length:669 Identity:305/669 - (45%)
Similarity:395/669 - (59%) Gaps:80/669 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 ILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGVRLCDALM 168
            |:||.....|......|||     |.....|        :|..|||:|||.|.|.:|:.|.|.||
Human    32 IVQQFGYQRRASDDGKLTD-----PSKTSNT--------IRVFLPNKQRTVVNVRNGMSLHDCLM 83

  Fly   169 KALKLRQLTPDMCEVST---THSGRHI-IPWHTDIGTLHVEEIFVRLLDKFPIRTHIKHQIIRKT 229
            ||||:|.|.|:.|.|..   .|.|:.. :.|:||..:|..||:.|..||..|:.|   |...|||
Human    84 KALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTT---HNFARKT 145

  Fly   230 FFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENP---DNGV-G 290
            |..|.||:.|::.|..||.|..|.::||:.|:.:||.:|..:  .:..||||..|.   |:|| .
Human   146 FLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDW--SNIRQLLLFPNSTIGDSGVPA 208

  Fly   291 FPG------RGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSNSAPN 349
            .|.      |.:..|..:||:.|.....:...::||  |||...         :||..||.|.||
Human   209 LPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSS--PSSEGS---------LSQRQRSTSTPN 262

  Fly   350 VCI--------------NNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHN---- 396
            |.:              ||:.:......|...::.|..:    ..||.|...|..|:..:|    
Human   263 VHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAI----RSHSESASPSALSSSPNNLSPT 323

  Fly   397 ------------RPRARSADESNKNLLL-RDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHW 448
                        |.||..:....||.:. |..:.|...|.|.|.|:::..|||||||||||:..|
Human   324 GWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKW 388

  Fly   449 HGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHV 513
            ||.||||.|.|..|:|.|.|||:||||:|:||||.|||||||.::|.:||||||||||||||||:
Human   389 HGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHL 453

  Fly   514 HVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSG 578
            ||.||||::..||||.||.||||||||||||||||:|||||||||.|:||||||||||.|:||||
Human   454 HVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSG 518

  Fly   579 EKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGR 643
            .:|..|||||:|||||||||||:.||:|||||||::|||:|||:...|||.||:|:|||:|||||
Human   519 SQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGR 583

  Fly   644 GLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPNLTQS 708
            |...||:|::..:.|:|:|||..||:|...::||||..:|:.:|.:..:||||:||||||:|.::
Human   584 GYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 648

  Fly   709 QLQND--EFLYLPSPKTPV 725
            ....|  ......||:.||
Human   649 AHTEDINACTLTTSPRLPV 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RafNP_001096867.3 RBD_RAF 142..212 CDD:340514 32/73 (44%)
C1_Raf 221..269 CDD:410361 19/47 (40%)
STKc_Raf 435..687 CDD:270964 174/251 (69%)
RAF1NP_001341618.1 Raf_RBD 57..131 CDD:176411 33/81 (41%)
C1_1 139..187 CDD:278556 20/47 (43%)
STKc_C-Raf 356..638 CDD:271051 185/281 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 378 1.000 Domainoid score I861
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 586 1.000 Inparanoid score I1004
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49873
OrthoDB 1 1.010 - - D129822at33208
OrthoFinder 1 1.000 - - FOG0001587
OrthoInspector 1 1.000 - - otm40979
orthoMCL 1 0.900 - - OOG6_100006
Panther 1 1.100 - - O PTHR44329
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X994
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.980

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