DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Raf and ksr2

DIOPT Version :10

Sequence 1:NP_525047.1 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster
Sequence 2:XP_009299513.1 Gene:ksr2 / 569127 ZFINID:ZDB-GENE-030131-8047 Length:966 Species:Danio rerio


Alignment Length:721 Identity:197/721 - (27%)
Similarity:303/721 - (42%) Gaps:149/721 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 QQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGV---------- 161
            :||..|.......|..:..:.||:.  .:.|:.|:......|...|..:.::.|.          
Zfish   260 RQRHFAHTPPRTPLVVNTMTPPGTP--QVRRRNKLKAPGTPPPASRKLIHLLPGFTALHRSKSHE 322

  Fly   162 -----RLCDA-LMKA--------LKLRQLTPDMCE--------VSTTHSGRHII---------PW 195
                 |:.|| ..||        ||:.......||        :.:.||.|...         |.
Zfish   323 FQLGNRIDDAQTPKAKKKNKPLNLKIHSSVAGSCENLPTQRSPLHSDHSLRSFFFPNFVPSTPPV 387

  Fly   196 HTD---IGTLHVEEIFVRLLDKFPIR---THIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNF 254
            |:|   ..||.|.    |...:.|.|   ..|||:...|.:.|.. |..|.:.:..|..|..|..
Zfish   388 HSDTPSANTLSVP----RWSPQIPRRDLGNSIKHRFSTKYWMSQT-CIVCGKGMLFGLKCKNCKL 447

  Fly   255 RFHQRCANRVPMLC----------QPF-------PMDSYYQLLLAENPDNGVGFPGRGTAVRFNM 302
            :.|.:|....|. |          :||       ..:...||:..|:....:..|.|.:.:..:.
Zfish   448 KCHNKCTKEAPP-CHLLIYHRGGREPFRDQVTSQGKEEARQLVRTESVPCDINNPLRYSDLHISQ 511

  Fly   303 ---------------------SSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSN- 345
                                 ||...|...|:..|.:...|||::..:.....|....|..:|| 
Zfish   512 TLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQSARQQKQSNL 576

  Fly   346 SAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSN-------STQASPTSTLKHNRPRAR-S 402
            :|.:......:.:..:|...:..:|...:.||......       ..:..|||..:.....|. |
Zfish   577 TASHFYKYKQQFIFPDVAPEVPTRAPQVILHPVLSEPGPKGSPLLQIEVEPTSDNEEGNDEAEGS 641

  Fly   403 ADE-SNKNLLLRDA-----KSSE-----ENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKT 456
            ||| ...||.|..|     |:|:     :.|:|..|::.||..||.|.||.||...|||.||::.
Zfish   642 ADEFEEMNLSLLSARNFPRKASQTSIFLQEWDIPMEQVEIGELIGKGRFGQVYHGRWHGEVAIRL 706

  Fly   457 LNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKF 520
            ::::..:..||:|||.||...:.|||.|::|||| |:..|.|||:|..|:|.:||..|..::...
Zfish   707 IDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSVVRDAKVVL 771

  Fly   521 KLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQ- 584
            .:|....|.:::.:||.|||||.|:|:|:||.|:| :::..|.|.||||.|.    ||..||.. 
Zfish   772 DVNKTRQIAQEMVKGMGYLHAKGILHKDMKSKNVF-YDNGKVVITDFGLFTI----SGVLQAGSR 831

  Fly   585 -------PTGSILWMAPEVIRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQ 636
                   |:|.:..:|||:||.      :...|:|.||||:|||.:.|||.|...|:     |:|
Zfish   832 RKDKLRIPSGWLCHLAPELIRQLSPETAENQLPFSKQSDVFAFGTIWYELHAREWPF-----KNQ 891

  Fly   637 ----ILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIH 697
                |::.||.| ::|.::|:  ...:.:..:...|..|..::||.|..|:.:||.    |||.:
Zfish   892 PAEVIIWQVGSG-MKPILTQI--GMGKEISDILLFCWAYEQEERPSFSKLMELLEK----LPKRN 949

  Fly   698 RSASEP 703
            |..|.|
Zfish   950 RRLSHP 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RafNP_525047.1 RBD_RAF 142..212 CDD:340514 22/113 (19%)
C1_Raf 221..269 CDD:410361 14/57 (25%)
STKc_Raf 435..687 CDD:270964 100/270 (37%)
ksr2XP_009299513.1 SAM_KSR1_N 23..76 CDD:466555
SAM_KSR1 84..151 CDD:463916
C1_KSR2 412..468 CDD:410423 14/57 (25%)
Protein Kinases, catalytic domain 678..948 CDD:473864 106/286 (37%)
Blue background indicates that the domain is not in the aligned region.

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