DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and Tnni3k

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_796040.3	Gene:	Tnni3k / 435766	MGIID:	2443276	Length:	834	Species:	Mus musculus

Alignment Length:	749	Identity:	184/749 - (24%)
Similarity:	284/749 - (37%)	Gaps:	160/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 YLIEYQELTSKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVH- 115
            |.|..:.|...|...|.:.|||.....|.:...:.||        :|:.       :|.|:.:|
Mouse    24 YAIIIERLEDDLQIKENEFQELRHIFGSDEAFSEVSL--------NYRT-------ERGLSLLHL 73

  Fly   116 ----HGNDLTDSLGSQPGSQCGTLTRQ--PKILLRAHLPNQQRTSVEVI-----SGVRLCDA--- 166
                .||..........|.:...|||.  |.:.|..:     :.|:|:|     ||..:..|
Mouse    74 CCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVY-----KDSLELITSLLHSGADVQQAGYG 133

  Fly   167 LMKALKLRQLT--PDMCEVSTTHSGR-------HIIPWHTDIGTLHVEEIFVRLLDKFPIRTHIK 222
            .:.||.:..:.  |:..||...|...       ...|.|  |...:..|....:|.||....::.
Mouse   134 GLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLH--IAAYYGHEQVTSVLLKFGADVNVS 196

  Fly   223 --------HQIIRKTFFSLVFCEGCRRLLFTG----------------FYCSQCNFRFHQRCANR 263
                    |....|.||::|      :||..|                .:||:  |..|    |.
Mouse   197 GEVGDRPLHLASAKGFFNIV------KLLVEGNKADVNAQDNEDHVPLHFCSR--FGHH----NI 249

  Fly   264 VPML------CQPFPMDSYYQLLLAENPDNG--------VGFPGRGTAVRFNMSSRSRSRRCSSS 314
            |..|      .||..::.|....|.....||        |...|..:..:.|:.|.:......:.
Mouse   250 VSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTY 314

  Fly   315 GSS----SSSKPPSSSSGNHRQGRPP-------------RISQDDRSNSAPN--VCINNIRSVTS 360
            |.:    ......::.:.||| ||..             |:.|....|.|..  |..:..||...
Mouse   315 GKNIDLVKFLLDQNAVNINHR-GRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGE 378

  Fly   361 EVQRSLIMQA----------------RPPLPHPCTDHSNS-------TQASPTSTLKHNRPRARS 402
            :.:::.:|.|                ||....||.::|..       :..||...:|      ..
Mouse   379 KDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIK------SM 437

  Fly   403 ADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKT-PSPA 465
            ..|....||||....|  .:::...||.....|||||||.||:...... ||:|.....| .|.:
Mouse   438 TKEKADVLLLRAELPS--RFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS 500

  Fly   466 QLQAFKNEVAMLKKTRHCNILLFMG-CVSKPS-LAIVTQWCEGSSLYKHVHVSETKFKLNTLIDI 528
            .:..|..||::|.:..|..::.|:| |:..|| .|||||:..|.||:..:|..:....|.:.:.|
Mouse   501 DVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII 565

  Fly   529 GRQVAQGMDYLHA--KNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILW 591
            ...||:||:|||:  :.||||||.|:||.|:||....:.|||.:........:....|| |::.|
Mouse   566 AVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP-GNLRW 629

  Fly   592 MAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSD 656
            |||||  ..:...|:.::||:::.:.::|||...:|:.|:........|....:..|....:...
Mouse   630 MAPEV--FTQCTRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKP 692

  Fly   657 APQALKRLAEDCIKYTPKDRPLFRPLLNMLENML 690
            ....|.|....|    |:.||.|..::..||..|
Mouse   693 ISSLLMRGWNAC----PEGRPEFSEVVRKLEECL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	17/86 (20%)
		C1_Raf	221..269	CDD:410361	15/77 (19%)
		STKc_Raf	435..687	CDD:270964	83/257 (32%)
Tnni3k	NP_796040.3	ANK repeat	66..98	CDD:293786	6/31 (19%)
		ANK 1	66..96		6/29 (21%)
		Ank_2	71..164	CDD:289560	21/97 (22%)
		ANK	99..220	CDD:238125	28/133 (21%)
		ANK repeat	100..131	CDD:293786	7/35 (20%)
		ANK 2	100..129		7/33 (21%)
		ANK 3	133..162		6/28 (21%)
		ANK repeat	134..164	CDD:293786	6/29 (21%)
		Ank_2	138..231	CDD:289560	20/100 (20%)
		ANK	161..289	CDD:238125	28/141 (20%)
		ANK repeat	166..197	CDD:293786	7/32 (22%)
		ANK 4	166..195		7/30 (23%)
		ANK repeat	199..231	CDD:293786	8/37 (22%)
		ANK 5	199..229		8/35 (23%)
		ANK	228..359	CDD:238125	25/137 (18%)
		ANK 6	233..262		7/34 (21%)
		Ank_4	237..286	CDD:290365	13/54 (24%)
		ANK repeat	268..301	CDD:293786	6/32 (19%)
		ANK 7	268..297		6/28 (21%)
		Ank_2	273..368	CDD:289560	17/95 (18%)
		ANK repeat	303..336	CDD:293786	5/33 (15%)
		ANK 8	303..334		2/30 (7%)
		ANK	333..>400	CDD:238125	14/67 (21%)
		ANK repeat	338..368	CDD:293786	4/29 (14%)
		ANK 9	338..367		4/28 (14%)
		Ank_4	339..400	CDD:290365	9/60 (15%)
		ANK 10	380..409		4/28 (14%)
		TyrKc	462..718	CDD:197581	84/262 (32%)
		PKc_TNNI3K	468..721	CDD:270966	85/259 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910