DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and Takl2

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster

Alignment Length:	239	Identity:	67/239 - (28%)
Similarity:	114/239 - (47%)	Gaps:	20/239 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 EEILIGPRIGSGSFGTVYRAHWHG-PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG 490
            |||.....||:|.:|:||||.|.. .:|:|.:.    ...:.:..:.|:..|.|..|.||:...|
  Fly    11 EEIQTKELIGTGFYGSVYRAVWRNREIALKRIR----EGCEDKKIEREIYQLTKASHVNIVELYG 71

  Fly   491 CVSKPSLA-IVTQWCEGSSLYKHVHV-SETKFKLNTLIDIGRQVAQGMDYLHA---KNIIHRDLK 550
            .......| ::.::.:|.||...:|. |:..:......:...|:|||:.|||.   |.:||||:|
  Fly    72 TSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIK 136

  Fly   551 S-NNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAF 614
            . |.:...:.|.:||.|||.....:     :..:...|:..:.||||:   :.|....:.|||::
  Fly   137 PLNTLLCEKGLKLKICDFGTVVDLS-----QSISCNAGTCRYKAPEVL---QGNKPDEKCDVYSW 193

  Fly   615 GIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAP 658
            .|..:|:|:...|:...:...::...:..| .|||:|.:.|..|
  Fly   194 AITFWEILSRKEPFEQYNTLFELYMAINEG-ERPDLSCIMSGCP 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	64/231 (28%)
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	64/236 (27%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	64/231 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930