DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and Lrrk

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	168/680 - (24%)
Similarity:	255/680 - (37%)	Gaps:	205/680 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 LRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFP-IRTHIKHQIIRKTFFSLVFC 236
            |.::.|.|.:|:             .:..|.|:.|.:.|.|.:| :.|...|.           .
  Fly  1581 LAEIRPHMSQVA-------------KLLALTVDHIDLLLEDWYPSLGTRFVHT-----------S 1621

  Fly   237 EGCRRLLFTGF-YCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENPD------------NG 288
            ||  |.|.|.. .|.:|.::...:..|.        |.|.....:....|.            :|
  Fly  1622 EG--RFLITRLVLCPRCLWKLQLQQNNE--------PSDREVPPVGCNRPSRSSRRGAGAYFLHG 1676

  Fly   289 VGFPGRGTAVR-----FNMSSRSRSRRCSSS---GSSSSSKPPSSSSGNHR----QGRPPRISQD 341
            ||.||...|:.     .|.::| |.||...|   ||.:.|.....|:|:.|    .|.|.....|
  Fly  1677 VGDPGEDGALNVFSAYLNATAR-RERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPD 1740

  Fly   342 DRSNSAPNVCI-----NNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHNRPRAR 401
               ||  |||.     ..|.||.::.:.|            |..|...:.|...       |...
  Fly  1741 ---NS--NVCYAWMIEECILSVYNQSKIS------------CPVHLEQSMAQLA-------PDVI 1781

  Fly   402 SADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHW-------HGPVAVKTLNV 459
            .||..:|:             .|.:|.|:.|..:|.|:||.|::|:.       ..|||:|.|..
  Fly  1782 FADIPDKH-------------TIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQP 1833

  Fly   460 KTP----SPAQLQAFK----------------------NEVAMLKKTRHCNILLFMGCVSKPSLA 498
            ..|    ..:.|.|||                      .|:|:|...:|.||:..:|...|| ||
  Fly  1834 VPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP-LA 1897

  Fly   499 IVTQWCE--G-SSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFL---- 556
            :|.:...  | .:|.:|...|......:|...:..|.|:.::|||.:.||:|||||.|:.:
  Fly  1898 LVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELP 1962

  Fly   557 --H-ED-----LSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYA 613
              | ||     :.:||.|:|: :.:|..||.|......|   :||||:||......|:.:.|.::
  Fly  1963 QPHTEDSPRNLVHIKIADYGI-SRQTAPSGAKGFGGTEG---FMAPEIIRYNGEEEYTEKVDCFS 2023

  Fly   614 FGIVMYELLAECLPY-GHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRP 677
            ||:.:||.::...|: ||.|.|:.||    .| .||.::|..:..|.....|...|....|:.||
  Fly  2024 FGMFIYENISLRQPFEGHESIKECIL----EG-SRPALTQRETQFPTCCLDLMVLCWHEQPRRRP 2083

  Fly   678 LFRPLLNMLE-----NMLRTLPKIHRSASEPNLTQS--QLQNDE----FLYLPS----------- 720
            ....::::|.     ::|..:...|.......:.||  .:.:||    .|:|||
  Fly  2084 TASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCS 2148

  Fly   721 ---------------------PKTPVNFNN 729
                                 ||||.|..|
  Fly  2149 PSGSLLQCNSISCSPQPQVAPPKTPENGAN 2178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	7/38 (18%)
		C1_Raf	221..269	CDD:410361	9/48 (19%)
		STKc_Raf	435..687	CDD:270964	87/300 (29%)
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	89/305 (29%)
		STKc_LRRK	1801..2095	CDD:270902	88/303 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930