Protein Alignment Raf and araf

DIOPT Version :10

• Sequence 1: NP_525047.1
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_991306.1
• Gene: araf / 403063
• ZFINID: ZDB-GENE-050102-2
• Length: 608
• Species: Danio rerio
• Alignment Length: 585
• Identity: 267/585 - (45%)
• Similarity: 357/585 - (61%)
• Gaps: 43/585 - (7%)

  Fly   143 LRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSGR-HIIPWHTDIGTLHVEE 206
            :|.:|||:|||.|.|..|..:.|:|.||||:|.|:.|.|.|.....|| .:..|.|||..|..||
Zfish    25 IRVYLPNKQRTVVNVRPGQTVYDSLDKALKVRGLSQDCCAVFRLLEGRKRLTEWDTDITPLVGEE 89

  Fly   207 IFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPF 271
            :.|.:||..|:   ..|..:|||||.|.:|:.|.:.||.||.|..|.::|||.|:::||.:|  .
Zfish    90 LLVEVLDDVPL---TMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKVPTVC--V 149

  Fly   272 PMDSYYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRR-CSSSGSSSSSKPPSSSSG--NHRQG 333
            .||:..:..:....|        ..|:....::.|.|:. ...:..|...:.|||.|.  ...:|
Zfish   150 DMDTMTKRCVNNTED--------CPAILIYPATNSISQSDLPLTSDSPGGELPSSPSNFCLFIRG 206

  Fly   334 RPPRISQDDRSNSAPNV------------------CINNIRSVTSEVQRSLIMQARPPLPHPCTD 380
            ...:..|..||.|.|||                  .|:.:.|.|.        ....|.|.....
Zfish   207 EDGQSLQRHRSTSTPNVHMVSTLEPGAAGLLEEPFKISTVASYTG--------YESSPKPSTSPP 263

  Fly   381 HSNSTQASPTSTLKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYR 445
            |..|....|..:....:.|.:|:.:..|.:.....:.|...|.:...|:.:..|||:||||||::
Zfish   264 HLGSPGRKPPKSPSEPKERKQSSSDDKKKVHRGGYRDSSYYWEVHPREVSMLKRIGAGSFGTVFK 328

  Fly   446 AHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLY 510
            ..|||.||:|.|.|..|:|.||||||||:.:|:||||.|||||||.:::|:.||:||||||||||
Zfish   329 GKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQWCEGSSLY 393

  Fly   511 KHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTR 575
            :|:||:||||.....||:.||.||||||||||||||||||||||||||..:||||||||||.|:|
Zfish   394 RHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSR 458

  Fly   576 WSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFM 640
            |||.:|..||:||||||||||||||:.|||:||||||.:|:|:|||::..|||.:|:|:|||:||
Zfish   459 WSGSQQVEQPSGSILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFM 523

  Fly   641 VGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPNL 705
            ||||.|.||:|::.|:.|:::|||..||:|:...:||||..:|..:|.:...||||.||||||:|
Zfish   524 VGRGYLSPDLSKLYSNCPKSMKRLIIDCLKFKRDERPLFPQILVSIEQVQELLPKIERSASEPSL 588

  Fly   706  705
            Zfish   589  588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_525047.1	RBD_RAF	142..212	CDD:340514	31/69 (45%)
		C1_Raf	221..269	CDD:410361	21/47 (45%)
		STKc_Raf	435..687	CDD:270964	165/251 (66%)
araf	NP_991306.1	RBD_ARAF	23..95	CDD:340653	31/69 (45%)
		C1_A_C-Raf	100..151	CDD:410420	22/55 (40%)
		STKc_A-Raf	311..575	CDD:271052	168/263 (64%)