DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and Map3k11

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001013168.1	Gene:	Map3k11 / 309168	RGDID:	1359261	Length:	850	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	108/381 - (28%)
Similarity:	162/381 - (42%)	Gaps:	94/381 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 QASPTSTLKHNRP--------RARSADE------SNKNLLLRDAK-SSEENW------------- 422
            :.||.:|..:..|        .....||      ....:|.|||. |.:|.|
  Rat    33 EGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFP 97

  Fly   423 -NILA-------------EEILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKTPSPAQL--QAF 470
             |.::             :|:.:...||.|.||.|||..|.|. ||||...........:  ::.
  Rat    98 SNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESV 162

  Fly   471 KNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQ 534
            :.|..:.....|.||:.... |:.:|:|.:|.::..|..|.:  .::..:...:.|::...|:|:
  Rat   163 RQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSR--ALAGRRVPPHVLVNWAVQIAR 225

  Fly   535 GMDYLHAK---NIIHRDLKSNNIFL--------HEDLSVKIGDFGLATAKTRWSGEKQANQPTGS 588
            ||.|||.:   .:||||||||||.|        .|..::||.|||||   ..|....|.: ..|:
  Rat   226 GMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLA---REWHKTTQMS-AAGT 286

  Fly   589 ILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLA--------ECL--PYGHISNKDQILFMVGR 643
            ..|||||||:   .:.:|..|||::||::::|||.        :||  .||...||
  Rat   287 YAWMAPEVIK---ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNK--------- 339

  Fly   644 GLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLE----NMLRTLPK 695
             |..|    :.|..|:...:|..||....|..||.|..:|..||    .:||.:|:
  Rat   340 -LTLP----IPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPR 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	88/276 (32%)
Map3k11	NP_001013168.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..37		1/3 (33%)
		SH3_MLK1-3	46..103	CDD:212992	10/56 (18%)
		STKc_MLK3	114..380	CDD:271049	91/288 (32%)
		STYKc	118..377	CDD:214568	88/281 (31%)
		Leucine-zipper 1	404..425
		Leucine-zipper 2	439..460
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910