Protein Alignment Raf and raf1a

DIOPT Version :10

• Sequence 1: NP_525047.1
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_571514.2
• Gene: raf1a / 30716
• ZFINID: ZDB-GENE-990415-41
• Length: 643
• Species: Danio rerio
• Alignment Length: 608
• Identity: 297/608 - (48%)
• Similarity: 375/608 - (61%)
• Gaps: 41/608 - (6%)

  Fly   143 LRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSGRHI----IPWHTDIGTLH 203
            :|..|||||||.|.|..|:.|...|:||||:|.|.|:.|.|.:.|.|:..    :.|.||..:|.
Zfish    51 IRVFLPNQQRTVVNVRPGMTLHSCLIKALKVRGLQPECCAVFSLHPGQRSKKSRMEWSTDSTSLI 115

  Fly   204 VEEIFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLC 268
            .||:.|.:||..|:.|   |..:||||..|.||:.|::.|..||.|.:|.::||:.|:.:||.:|
Zfish   116 GEELLVEVLDHVPLTT---HNFVRKTFLKLAFCDICQKFLLNGFRCQRCGYKFHEHCSTKVPTMC 177

  Fly   269 QPFPMDSYYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQG 333
            ..:  .:..||||...|... |.|...:.....|  |....|..||.....|.|..|   |:...
Zfish   178 VDW--TNIRQLLLFPTPGES-GAPSLPSLTSRRM--RESLTRIPSSSVHRYSNPHVS---NYTSP 234

  Fly   334 RPP---RISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHS------------- 382
            .||   .::|..||.|.|||   .:.|.|..|..|||.....|... |...|
Zfish   235 YPPSGAALTQRLRSTSTPNV---TMLSTTVPVDSSLIELDTSPSSW-CQQFSLKRRDAIRVHSSA 295

  Fly   383 -NSTQASPT---STLKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTV 443
             :|...|||   ....|....|.:..|..| :..||.:.|...|.|.|.|:::..||||||||||
Zfish   296 GSSPNQSPTGWNQASAHIPASALNPQEKVK-IRPRDKRDSSYYWEIEANEVVLLSRIGSGSFGTV 359

  Fly   444 YRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSS 508
            ::..|||.||||.|.|..|:|.|.|||:||||:|:||||.|||||||.::|.:||||||||||||
Zfish   360 HKGKWHGDVAVKVLKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKGNLAIVTQWCEGSS 424

  Fly   509 LYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK 573
            ||||:||.||.|::..||||.||.||||||||||||||||:|||||||||.|:||||||||||.|
Zfish   425 LYKHLHVLETNFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK 489

  Fly   574 TRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQIL 638
            .||||.:|..||:||||||||||||||:.||||||||||::|||::||:...|||..|.|:|||:
Zfish   490 ARWSGSQQVEQPSGSILWMAPEVIRMQDNNPYSFQSDVYSYGIVLFELMTGELPYSQIGNRDQII 554

  Fly   639 FMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEP 703
            ||||||.|.||:|::....|:|:|||..||||.:..:||||..:|:.:|.:..:||||:||||||
Zfish   555 FMVGRGYLSPDLSKLYKRCPKAMKRLVADCIKKSKDERPLFPQILSSIELLQHSLPKINRSASEP 619

  Fly   704 NLTQ-SQLQNDEFLYLPSPKTPV 725
            :|.: ||.::.....|.|.|.||
Zfish   620 SLHRASQSEDISSCTLTSMKLPV 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_525047.1	RBD_RAF	142..212	CDD:340514	31/72 (43%)
		C1_Raf	221..269	CDD:410361	19/47 (40%)
		STKc_Raf	435..687	CDD:270964	173/251 (69%)
raf1a	NP_571514.2	RBD_CRAF	48..124	CDD:340655	31/72 (43%)
		C1_A_C-Raf	129..180	CDD:410420	21/53 (40%)
		STKc_C-Raf	332..614	CDD:271051	184/281 (65%)