DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and Ripk1

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001100820.1	Gene:	Ripk1 / 306886	RGDID:	1310158	Length:	658	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	98/343 - (28%)
Similarity:	170/343 - (49%)	Gaps:	48/343 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 SEENWNILAEEILIGPRIGSGSFGTV----YRAHWHGPVAVKTLNVKT-PSPAQL-QAFKNEVAM 476
            |.:|..:.::::|....:.||.||.|    :|.  ||.|.:|  .|.| |:.|:. :|...|..|
  Rat     6 SLDNIKMASDDLLERKDLDSGGFGKVSLCFHRT--HGFVILK--KVYTGPNRAEYNEALLEEGKM 66

  Fly   477 LKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGR---QVAQGMD 537
            :.:.||..::..:| .:.:.:.::|.::.|..:|   :||.:||..:...:. ||   ::.:||.
  Rat    67 MHRLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNL---MHVLKTKESVPLSVK-GRIIVEIIEGMH 127

  Fly   538 YLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWS--------GEKQANQPT----GSIL 590
            |||.:.:||:|||..||.:..|..:||.|.|:|:.|| ||        .:::|:..|    |::.
  Rat   128 YLHDEGVIHKDLKPENILVDRDFHIKIADLGVASFKT-WSKLTKEEHNKQREASSVTKKNGGTLY 191

  Fly   591 WMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRS 655
            :||||.:......| :.:||||:|.||::.:.|...||.::...:|.|..:..| .||::..:..
  Rat   192 YMAPEHLTDINTKP-TEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSG-NRPNVEDILE 254

  Fly   656 DAPQALKRLAEDCIKYTPKDRPL-------FRPLL-----NMLENMLRTLPKIHRSASEPNLTQS 708
            ..|:.:..|.|.|.:..|:|||.       |:|..     ..:|..:.:|.|.:.|.|.......
  Rat   255 FCPREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKKEYPSQSPVLKRMF 319

  Fly   709 QLQNDEFLYLPSPKTPVN 726
            .||:|   .:|.|.:..|
  Rat   320 SLQHD---CVPLPPSRSN 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	84/285 (29%)
Ripk1	NP_001100820.1	PKc_like	23..290	CDD:419665	84/277 (30%)
Ripk1	NP_001100820.1	Death_RIP1	570..655	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910