DRSC/TRiP Functional Genomics Resources

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Protein Alignment Raf and Map3k13

DIOPT Version :9

Sequence 1:NP_001096867.3 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_001014000.2 Gene:Map3k13 / 303823 RGDID:1561227 Length:958 Species:Rattus norvegicus


Alignment Length:437 Identity:117/437 - (26%)
Similarity:186/437 - (42%) Gaps:80/437 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 MSSRSRSRRCSS-------SGSSSSSKPPSSSSGNHRQGRPPRISQD-------DRSNSAPNVCI 352
            |::......|||       ....|..:...::.|||...:.|..||:       :.:....:...
  Rat     1 MANPQEHLSCSSLPHLPLTENKISGGRNELAAMGNHPSPKFPEDSQERVVAIQSELTEITGSPVS 65

  Fly   353 NNIRSVTSEVQRS----LIMQARPPLPHPCT---DHSNSTQASPTSTLKHNRPR------ARSAD 404
            ..:.:..||..||    .::|.|.......|   .:||:.....|     |.|.      :||..
  Rat    66 TTVLTSVSEDSRSQFENSVLQLREQDESEVTVSPGNSNTVDGENT-----NGPEDIKIQFSRSGS 125

  Fly   405 ESNKNL------------LLRDAKSS------EENWNILAEEILIGPRIGSGSFGTVYRAHWHG- 450
            .|...|            ::..|.|:      ::.|.:..|||.....:|||:.|.|:...:.. 
  Rat   126 GSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE 190

  Fly   451 PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVH 514
            .||:|.:..:.         :.::..|:|.:|.||:.|.| |...|...|:.::|....||:.:.
  Rat   191 EVAIKKVREQN---------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR 246

  Fly   515 VSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFG----LATAKTR 575
            ... |.....|:|....:|.||:|||...||||||||.|:.:....:|||.|||    |:...|:
  Rat   247 AGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK 310

  Fly   576 WSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFM 640
            .|.       .|::.||||||||.:   |.|.:.|:::||:|::|||...:||..: :...|::.
  Rat   311 MSF-------AGTVAWMAPEVIRNE---PVSEKVDIWSFGVVLWELLTGEIPYKDV-DSSAIIWG 364

  Fly   641 VGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLE 687
            ||...|.   ..|.|..|...|.|.:...:..|::||.||..|..|:
  Rat   365 VGSNSLH---LPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RafNP_001096867.3 RBD_RAF 142..212 CDD:340514
C1_Raf 221..269 CDD:410361
STKc_Raf 435..687 CDD:270964 83/257 (32%)
Map3k13NP_001014000.2 STYKc 168..402 CDD:214568 82/257 (32%)
STKc_MAP3K12_13 174..410 CDD:270961 84/259 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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